The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Recruitment of a hedgehog Regulatory Circuit in Butterfly Eyespot Evolution
Abstract
The origin of new morphological characters is a long-standing problem in evolutionary biology. Novelties arise through changes in development, but the nature of these changes is largely unknown. In butterflies, eyespots have evolved as new pattern elements that develop from special organizers called foci. Formation of these foci is associated with novel expression patterns of the Hedgehog signaling protein, its receptor Patched, the transcription factor Cubitus interruptus, and the engrailed target gene that break the conserved compartmental restrictions on this regulatory circuit in insect wings. Redeployment of preexisting regulatory circuits may be a general mechanism underlying the evolution of novelties.
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Lee, J. J., von Kessler, D. P., Parks, S., & Beachy, P. A. (1992) · Cell · doi:10.1016/0092-8674(92)90264-d · Cited by 581
Research works printed but not linked: 22
- Müller G. B., Wagner G. P., Annu. Rev. Ecol. Syst. 22, 229 (1991). · doi:10.1146/annurev.es.22.110191.001305 · Paper page
- H. F. Nijhout The Development and Evolution of Butterfly Wing Patterns (Smithsonian Institution Press Washington DC 1991).
- Brakefield P. M., Reitsma N., Entomol. Entomol. 16, 291 (1991).
- 10.1016/0012-1606(80)90403-0 · DOI · Paper page
- Brakefield P., French V., ibid. 168, 98 (1995).
- 10.1146/annurev.cellbio.12.1.161 · DOI
- Tabin C. J., McMahon A. P., Trends Cell Biol. 7, 442 (1997). · DOI
- Johnson R. L., Scott M. P., Curr. Opin. Genet. Dev. 8, 450 (1998). · DOI
- Alexandre C., Jacinto A., Ingham P. W., Genes Dev. 10, 2003 (1996). · DOI · Paper page
- D. N. Keys D. L. Lewis J. E. Selegue B. Pearson S. B. Carroll unpublished data.
- Eaton S., Kornberg T. B., Genes Dev. 4, 1068 (1990). · DOI · Paper page
- Phillips R. G., Roberts I. J., Ingham P. W., Whittle J. R., Development 110, 105 (1990); · DOI
- Slusarski D. C., Motzny C. K., Holmgren R., Genetics 139, 229 (1995) . · DOI
- Schwartz C., Locke J., Nishida C., Kornberg T. B., Development 121, 1625 (1995). · DOI
- 10.1126/science.272.5268.1621 · DOI · Paper page
- Hepker J., Wang Q. T., Motzny C. K., Holmgren R., Orenic T. V., Development 124, 549 (1997). · DOI
- Monteiro A., Brakefield P. M., French V., Evolution 48, 1147 (1995). · doi:10.2307/2410374
- 10.1242/dev.124.22.4697 · DOI · Paper page
- Blair S., ibid. 119, 339 (1992).
- 10.1126/science.7912449 · DOI · Paper page
- 10.1038/384236a0 · DOI · Paper page
- Patel N. H., et al., Cell 58, 955 (1989). · DOI · Paper page
Cited by
A Molecular Link between Stem Cell Regulation and Floral Patterning in Arabidopsis
Lohmann, J. U., Hong, R. L., Hobe, M., Busch, M. A., Parcy, F., Simon, R., & Weigel, D. (2001) · Cell · doi:10.1016/s0092-8674(01)00384-1 · Cited by 696
Mechanisms and functions of Hedgehog signalling across the metazoa
Ingham, P. W., Nakano, Y., & Seger, C. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2984 · Cited by 605
The Changing Role of the Embryo in Evolutionary Thought: Roots of Evo-Devo
Amundson, R. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9781139164856 · Cited by 584
The evolution of signalling pathways in animal development
Pires-daSilva, A., & Sommer, R. J. (2003) · Nature Reviews Genetics · doi:10.1038/nrg977 · Cited by 466
The evolution of hierarchical gene regulatory networks
Erwin, D. H., & Davidson, E. H. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2499 · Cited by 454
Metadata
- Authors
- Keys, D. N., Lewis, D. L., Selegue, J. E., Pearson, B. J., Goodrich, L. V., Johnson, R. L., Gates, J., Scott, M. P., & Carroll, S. B.
- Venue
- Science
- Published
- 1999-01-22
- Volume
- 283
- Issue
- 5401
- Pages
- 532-534
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2097324875
- Cited by
- 352
- References
- 1
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Keys, D. N., Lewis, D. L., Selegue, J. E., Pearson, B. J., Goodrich, L. V., Johnson, R. L., Gates, J., Scott, M. P., & Carroll, S. B. (1999). Recruitment of a hedgehog Regulatory Circuit in Butterfly Eyespot Evolution. Science. https://doi.org/10.1126/science.283.5401.532
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
