The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Erythropoietin Receptor Activation by a Ligand-Induced Conformation Change
Abstract
Erythropoietin and other cytokine receptors are thought to be activated through hormone-induced dimerization and autophosphorylation of JAK kinases associated with the receptor intracellular domains. An in vivo protein fragment complementation assay was used to obtain evidence for an alternative mechanism in which unliganded erythropoietin receptor dimers exist in a conformation that prevents activation of JAK2 but then undergo a ligand-induced conformation change that allows JAK2 to be activated. These results are consistent with crystallographic evidence of distinct dimeric configurations for unliganded and ligand-bound forms of the erythropoietin receptor.
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Cites
Dimerization of cell surface receptors in signal transduction
Heldin, C.-H. (1995) · Cell · doi:10.1016/0092-8674(95)90404-2 · Cited by 1,634
Kaufman, R. J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.3.689 · Cited by 135
Cited by
The JAK/STAT signaling pathway: from bench to clinic
Hu, X., li, J., Fu, M., Zhao, X., & Wang, W. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00791-1 · Cited by 2,633
Structure and signalling in the IL-17 receptor family
Gaffen, S. L. (2009) · Nature reviews. Immunology · doi:10.1038/nri2586 · Cited by 1,475
JAK-STAT Signaling: From Interferons to Cytokines
Schindler, C., Levy, D. E., & Decker, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r700016200 · Cited by 1,258
Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor
Kunishima, N., Shimada, Y., Tsuji, Y., Sato, T., Yamamoto, M., Kumasaka, T., Nakanishi, S., Jingami, H., & Morikawa, K. (2000) · Nature · doi:10.1038/35039564 · Cited by 1,249
Atypical Membrane Topology and Heteromeric Function of Drosophila Odorant Receptors In Vivo
Benton, R., Sachse, S., Michnick, S. W., & Vosshall, L. B. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040020 · Cited by 1,015
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Metadata
- Authors
- Remy, I., Wilson, I. A., & Michnick, S. W.
- Venue
- Science
- Published
- 1999-02-12
- Volume
- 283
- Issue
- 5404
- Pages
- 990-993
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061776631
- Cited by
- 634
- References
- 2
- FWCI
- 26.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Remy, I., Wilson, I. A., & Michnick, S. W. (1999). Erythropoietin Receptor Activation by a Ligand-Induced Conformation Change. Science. https://doi.org/10.1126/science.283.5404.990
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
