Dimerization of cell surface receptors in signal transduction
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EGFR is a member of the receptor tyrosine kinase family and a typical transmembrane receptor that initiates signaling cascades upon ligand-stimulated dimerization, thereby activating its tyrosine kinase and multiple downstream effectors.
“Epidermal growth factor receptor (EGFR), a member of the receptor tyrosine kinase family, is a typical transmembrane receptor that initiates signaling cascades upon ligand-stimulated dimerization, thereby activating its tyrosine kinase and multiple downstream effectors.99–101”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [100]
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- Authors
- Heldin, C.-H.
- Affiliations
- Ludwig Cancer Research (SE)
- Corresponding author
- Heldin, Carl-Henrik
- ORCID
- Heldin, Carl-Henrik
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1995-01
- Volume
- 80
- Issue
- 2
- Pages
- 213-223
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2008940139
- Cited by
- 1,634
- References
- 114
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 19 · 2023: 21 · 2022: 23 · 2021: 10 · 2020: 24 · 2019: 19 · 2018: 19 · 2017: 23 · 2016: 34 · 2015: 31 · 2014: 35 · 2013: 30 · 2012: 26
- FWCI
- 14.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- receptor dimerization, cell surface receptors, signal transduction, receptor oligomerization
- MeSH terms
- Animals, Humans, Phosphorylation, Protein-Tyrosine Kinases, Receptors, Antigen, Receptors, Cell Surface, Signal Transduction, Protein Serine-Threonine Kinases, Receptors, Cytokine, Receptors, Tumor Necrosis Factor, Receptor Protein-Tyrosine Kinases, Macromolecular Substances
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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