The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Three-Dimensional Structure of a Recombinant Gap Junction Membrane Channel
Abstract
Gap junction membrane channels mediate electrical and metabolic coupling between adjacent cells. The structure of a recombinant cardiac gap junction channel was determined by electron crystallography at resolutions of 7.5 angstroms in the membrane plane and 21 angstroms in the vertical direction. The dodecameric channel was formed by the end-to-end docking of two hexamers, each of which displayed 24 rods of density in the membrane interior, which is consistent with an α-helical conformation for the four transmembrane domains of each connexin subunit. The transmembrane α-helical rods contrasted with the double-layered appearance of the extracellular domains. Although not indicative for a particular type of secondary structure, the protein density that formed the extracellular vestibule provided a tight seal to exclude the exchange of substances with the extracellular milieu.
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Self-citationThe Gap Junction Communication Channel
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Self-citationConnections with Connexins: the Molecular Basis of Direct Intercellular Signaling
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Cited by
Macrophages Facilitate Electrical Conduction in the Heart
Hulsmans, M., Clauss, S., Xiao, L., Aguirre, A. D., King, K. R., Hanley, A., Hucker, W. J., Wülfers, E. M., Seemann, G., Courties, G., et al. (2017) · Cell · doi:10.1016/j.cell.2017.03.050 · Cited by 1,011
Gap junctions and connexin-interacting proteins
Giepmans, B. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.12.009 · Cited by 450
The gap junction cellular internet: connexin hemichannels enter the signalling limelight
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Ackert, C. L., Gittens, J. E. I., O'Brien, M. J., Eppig, J. J., & Kidder, G. M. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0216 · Cited by 356
Metadata
- Authors
- Unger, V. M., Kumar, N. M., Gilula, N. B., & Yeager, M.
- Venue
- Science
- Published
- 1999-02-19
- Volume
- 283
- Issue
- 5405
- Pages
- 1176-1180
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2016665408
- Cited by
- 542
- References
- 29
- FWCI
- 12.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Unger, V. M., Kumar, N. M., Gilula, N. B., & Yeager, M. (1999). Three-Dimensional Structure of a Recombinant Gap Junction Membrane Channel. Science. https://doi.org/10.1126/science.283.5405.1176
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
