The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.
Role of Pitx1 Upstream of Tbx4 in Specification of Hindlimb Identity
Abstract
In spite of recent breakthroughs in understanding limb patterning, the genetic factors determining the differences between the forelimb and the hindlimb have not been understood. The genes Pitx1 and Tbx4 encode transcription factors that are expressed throughout the developing hindlimb but not forelimb buds. Misexpression of Pitx1 in the chick wing bud induced distal expression of Tbx4, as well as HoxC10 and HoxC11, which are normally restricted to hindlimb expression domains. Wing buds in which Pitx1 was misexpressed developed into limbs with some morphological characteristics of hindlimbs: the flexure was altered to that normally observed in legs, the digits were more toe-like in their relative size and shape, and the muscle pattern was transformed to that of a leg.
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“In amniotes pitx1 operates in the patterning system that organizes the subparts of the appendages developing from the hind limb buds, and forced expression in forelimb buds transforms them into hindlimbs (Logan and Tabin, 1999; Szeto et al., 1999).”
From Evolution of Gene Regulatory Networks Controlling Body Plan Development (2011) · cites this paper as Logan and Tabin, 1999
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Cites
A series of normal stages in the development of the chick embryo
Hamburger, V., & Hamilton, H. L. (1951) · Journal of Morphology · doi:10.1002/jmor.1050880104 · Cited by 12,254
Sonic hedgehog mediates the polarizing activity of the ZPA
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Self-citationRoles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development
Crossley, P. H., Minowada, G., MacArthur, C. A., & Martin, G. R. (1996) · Cell · doi:10.1016/s0092-8674(00)80999-x · Cited by 583
Fibroblast growth factors induce additional limb development from the flank of chick embryos
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Analysis of Hox gene expression in the chick limb bud
Nelson, C. E., Morgan, B. A., Burke, A. C., Laufer, E., DiMambro, E., Murtaugh, L. C., Gonzales, E., Tessarollo, L., Parada, L. F., & Tabin, C. J. (1996) · Development · doi:10.1242/dev.122.5.1449 · Cited by 483
Self-citationLogan, M. P. O., Pagán-Westphal, S. M., Smith, D. M., Paganessi, L. A., & Tabin, C. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81474-9 · Cited by 455
Self-citationLamonerie, T., Tremblay, J., Lanctôt, C., Therrien, M., Gauthier, Y., & Drouin, J. (1996) · Genes & Development · doi:10.1101/gad.10.10.1284 · Cited by 416
Muscle and tendon morphogenesis in the avian hind limb
Kardon, G. (1998) · Development · doi:10.1242/dev.125.20.4019 · Cited by 408
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Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb
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Research works printed but not linked: 3
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- The cartilage elements were stained with Alcian blue as previously described (6). Whole-mount immunohistochemistry with MF20 antibody to muscle myosin was carried out as described [M. W. Klymkowsky and J. Hanken Eds. Whole-Mount Staining of Xenopus and Other Vertebrates (Academic Press San Diego 1991)]. Detection was carried out with a horseradish peroxidase–conjugated secondary antibody (Jackson Immunoresearch West Grove PA diluted 1:200).
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Bickley, S. R. B., & Logan, M. P. O. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409913111 · Cited by 46
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Metadata
- Authors
- Logan, M., & Tabin, C. J.
- Affiliations
- Harvard University (US)
- Corresponding author
- Tabin, Clifford J.
- Venue
- Science
- Published
- 1999-03-12
- Volume
- 283
- Issue
- 5408
- Pages
- 1736-1739
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2042190289
- Cited by
- 304
- References
- 22
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 15 · 2020: 11 · 2019: 11 · 2018: 6 · 2017: 16 · 2016: 12 · 2015: 9 · 2014: 6 · 2013: 14 · 2012: 14
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Developmental Biology › Congenital limb and hand anomalies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- PITX1, TBX4, limb patterning, chick wing bud, HOXC10, HOXC11, transcription factors, digit morphology
- MeSH terms
- Animals, Chick Embryo, Ectoderm, Feathers, Foot, Genetic Vectors, Hindlimb, Mesoderm, Retroviridae, Transcription Factors, Wings, Animal, Cell Death, Homeodomain Proteins, Muscle, Skeletal, Gene Expression Regulation, Developmental, Limb Buds, Body Patterning, T-Box Domain Proteins, Avian Proteins, Paired Box Transcription Factors
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