Cited by 304Developmental Biology and Gene RegulationCongenital limb and hand anomaliesCongenital heart defects research

The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.

Role of Pitx1 Upstream of Tbx4 in Specification of Hindlimb Identity

Logan, Malcolm, Tabin, Clifford J.·1999·Science

DOI 10.1126/science.283.5408.1736

Open this paper in CoChat — free account

Abstract

In spite of recent breakthroughs in understanding limb patterning, the genetic factors determining the differences between the forelimb and the hindlimb have not been understood. The genes Pitx1 and Tbx4 encode transcription factors that are expressed throughout the developing hindlimb but not forelimb buds. Misexpression of Pitx1 in the chick wing bud induced distal expression of Tbx4, as well as HoxC10 and HoxC11, which are normally restricted to hindlimb expression domains. Wing buds in which Pitx1 was misexpressed developed into limbs with some morphological characteristics of hindlimbs: the flexure was altered to that normally observed in legs, the digits were more toe-like in their relative size and shape, and the muscle pattern was transformed to that of a leg.

Integrity signals

Registry

Crossref · 10.1126/science.283.5408.1736

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A series of normal stages in the development of the chick embryo
Hamburger, V., & Hamilton, H. L. (1951) · Journal of Morphology · doi:10.1002/jmor.1050880104 · Cited by 12,254
Sonic hedgehog mediates the polarizing activity of the ZPA
Riddle, R. D., Johnson, R. L., Laufer, E., & Tabin, C. J. (1993) · Cell · doi:10.1016/0092-8674(93)90626-2 · Cited by 2,285
Self-citation
Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development
Crossley, P. H., Minowada, G., MacArthur, C. A., & Martin, G. R. (1996) · Cell · doi:10.1016/s0092-8674(00)80999-x · Cited by 583
Fibroblast growth factors induce additional limb development from the flank of chick embryos
Cohn, M. J., Izpisúa‐Belmonte, J. C., Abud, H. E., Heath, J. K., & Tickle, C. A. (1995) · Cell · doi:10.1016/0092-8674(95)90352-6 · Cited by 573
Analysis of Hox gene expression in the chick limb bud
Nelson, C. E., Morgan, B. A., Burke, A. C., Laufer, E., DiMambro, E., Murtaugh, L. C., Gonzales, E., Tessarollo, L., Parada, L. F., & Tabin, C. J. (1996) · Development · doi:10.1242/dev.122.5.1449 · Cited by 483
Self-citation
The Transcription Factor Pitx2 Mediates Situs-Specific Morphogenesis in Response to Left-Right Asymmetric Signals
Logan, M. P. O., Pagán-Westphal, S. M., Smith, D. M., Paganessi, L. A., & Tabin, C. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81474-9 · Cited by 455
Self-citation
Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene.Preprint
Lamonerie, T., Tremblay, J., Lanctôt, C., Therrien, M., Gauthier, Y., & Drouin, J. (1996) · Genes & Development · doi:10.1101/gad.10.10.1284 · Cited by 416
Muscle and tendon morphogenesis in the avian hind limb
Kardon, G. (1998) · Development · doi:10.1242/dev.125.20.4019 · Cited by 408
Involvement of FGF8 in initiation, outgrowth and patterning of the vertebrate limb
Vogel, A., Rodriguez, C., & Izpisúa‐Belmonte, J. C. (1996) · Trends in Genetics · doi:10.1016/s0168-9525(96)80013-8 · Cited by 333
Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb
Vogel, A., Rodriguez, C., & Izpisúa‐Belmonte, J. C. (1996) · Development · doi:10.1242/dev.122.6.1737 · Cited by 322

Show all 22 references

Research works printed but not linked: 3

Logan M., Simon H.-G., Tabin C., ibid. 125, 2825 (1998).
The cartilage elements were stained with Alcian blue as previously described (6). Whole-mount immunohistochemistry with MF20 antibody to muscle myosin was carried out as described [M. W. Klymkowsky and J. Hanken Eds. Whole-Mount Staining of Xenopus and Other Vertebrates (Academic Press San Diego 1991)]. Detection was carried out with a horseradish peroxidase–conjugated secondary antibody (Jackson Immunoresearch West Grove PA diluted 1:200).
Pautou M.-P., Heydayat I., Kieny M., Arch. Anat. Microsc. Morphol. Exp. 71, 193 (1982).

Sorted by citations

Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks
Shapiro, M. D., Marks, M. E., Peichel, C. L., Blackman, B. K., Nereng, K. S., Jónsson, B., Schluter, D., & Kingsley, D. M. (2004) · Nature · doi:10.1038/nature02415 · Cited by 861
Bone Development
Olsen, B. R., Reginato, A. M., & Wang, W. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.191 · Cited by 828
Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis
Lin, C. R., Kioussi, C., O’Connell, S. M., Briata, P., Szeto, D. P., Liu, F. C., Izpisúa‐Belmonte, J. C., & Rosenfeld, M. G. (1999) · Nature · doi:10.1038/45803 · Cited by 612
Mechanisms of retinoic acid signalling and its roles in organ and limb development
Cunningham, T. J., & Duester, G. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3932 · Cited by 595
A Pituitary Cell-Restricted T Box Factor, Tpit, Activates POMC Transcription in Cooperation with Pitx Homeoproteins
Lamolet, B., Pulichino, A.-M., Lamonerie, T., Gauthier, Y., Brue, T. C., Enjalbert, A., & Drouin, J. (2001) · Cell · doi:10.1016/s0092-8674(01)00282-3 · Cited by 541
Evolution of Gene Regulatory Networks Controlling Body Plan Development
Peter, I. S., & Davidson, E. H. (2011) · Cell · doi:10.1016/j.cell.2011.02.017 · Cited by 417
Patterning Mechanisms Controlling Vertebrate Limb Development
Capdevila, J., & Belmonte, J. C. I. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.87 · Cited by 404
Canalization, developmental stability, and morphological integration in primate limbs
Hallgrímsson, B., Willmore, K. E., & Hall, B. K. (2002) · American Journal of Physical Anthropology · doi:10.1002/ajpa.10182 · Cited by 391
DUX4 , a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1
Dixit, M., Ansseau, E., Tassin, A., Winokur, S. T., Shi, R., Qian, H., Sauvage, S., Mattéotti, C., Acker, A.-M. V., Léo, O., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708659104 · Cited by 387
SERIAL HOMOLOGY AND THE EVOLUTION OF MAMMALIAN LIMB COVARIATION STRUCTURE
Young, N. M., & Hallgrímsson, B. (2005) · Evolution · doi:10.1111/j.0014-3820.2005.tb00980.x · Cited by 324
The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity
Rodrı́guez-Esteban, C., Tsukui, T., Yonei‐Tamura, S., Magallon, J., Tamura, K., & Belmonte, J. C. I. (1999) · Nature · doi:10.1038/19769 · Cited by 307
Theheartstringsmutation in zebrafish causes heart/fin Tbx5 deficiency syndrome
Garrity, D. M., Childs, S. J., & Fishman, M. C. (2002) · Development · doi:10.1242/dev.129.19.4635 · Cited by 295
Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart
Stennard, F. A., Costa, M. W., Elliott, D. A., Rankin, S. A., Haast, S. J. P., Lai, D., McDonald, L., Niederreither, K., Dollé, P., Bruneau, B. G., et al. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00385-3 · Cited by 289
Tbx5is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo
Agarwal, P., Wylie, J. N., Galcerán, J., Arkhitko, O., Li, C., Deng, C., Grosschedl, R., & Bruneau, B. G. (2003) · Development · doi:10.1242/dev.00191 · Cited by 277
Isl1Cre reveals a common Bmp pathway in heart and limb development
Yang, L., Cai, C.-L., Lin, L., Qyang, Y., Chung, C., Monteiro, R. M., Mummery, C. L., Fishman, G. I., Cogen, A., & Evans, S. (2006) · Development · doi:10.1242/dev.02322 · Cited by 267
Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois
Naiche, L. A., & Papaioannou, V. E. (2003) · Development · doi:10.1242/dev.00504 · Cited by 251
Tbx5 is required for forelimb bud formation and continued outgrowth
Rallis, C., Bruneau, B. G., Buono, J. D., Seidman, C. E., Seidman, J. G., Nissim, S., Tabin, C. J., & Logan, M. P. O. (2003) · Development · doi:10.1242/dev.00473 · Cited by 241
Self-citation
Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation
Takeuchi, S., Takeda, K., Oishi, I., Nomi, M., Ikeya, M., Itoh, K., Tamura, S., Ueda, T., Hatta, T., Otani, H., et al. (2000) · Genes to Cells · doi:10.1046/j.1365-2443.2000.00300.x · Cited by 224
Parallel genetic origins of pelvic reduction in vertebrates
Shapiro, M. D., Bell, M. A., & Kingsley, D. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604706103 · Cited by 216
The limb identity geneTbx5promotes limb initiation by interacting withWnt2bandFgf10
Ng, J. K., Kawakami, Y., Büscher, D., Raya, Á., Itoh, T., Koth, C. M., Esteban, C. R., Rodríguez‐León, J., Garrity, D. M., Fishman, M. C., et al. (2002) · Development · doi:10.1242/dev.129.22.5161 · Cited by 209
Signaling and Transcriptional Mechanisms in Pituitary Development
Dasen, J. S., & Rosenfeld, M. G. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.327 · Cited by 208
Antagonistic Signals between BMP4 and FGF8 Define the Expression of Pitx1 and Pitx2 in Mouse Tooth-Forming Anlage
Amand, T. R. S., Zhang, Y., Semina, E. V., Zhao, X., Hu, Y., Nguyen, L., Murray, J. C., & Chen, Y. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9547 · Cited by 208
T-box genes in human disorders
Packham, E. A. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg077 · Cited by 202
T-box genes in development: From hydra to humans
Papaioannou, V. E. (2001) · International review of cytology · doi:10.1016/s0074-7696(01)07002-4 · Cited by 190
Limb development: a paradigm of gene regulation
Petit, F., Sears, K. E., & Ahituv, N. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2016.167 · Cited by 198
Mutations in the Human TBX4 Gene Cause Small Patella Syndrome
Bongers, E. M. H. F., Duijf, P. H. G., van Beersum, S. E. C., Schoots, J., van Kampen, A., Burckhardt, A., Hamel, B. C. J., Losan, F., Hoefsloot, L. H., Yntema, H. G., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/421331 · Cited by 185
Pitx1andPitx2are required for development of hindlimb buds
Marcil, A., Dumontier, É., Chamberland, M., Camper, S. A., & Drouin, J. (2002) · Development · doi:10.1242/dev.00192 · Cited by 177
The Spectrum of Mutations in TBX3: Genotype/Phenotype Relationship in Ulnar-Mammary Syndrome
Bamshad, M., Le, T., Watkins, W. S., Dixon, M. E., Kramer, B. E., Roeder, A. D., Carey, J. C., Root, S., Schinzel, A., Van Maldergem, L., et al. (1999) · The American Journal of Human Genetics · doi:10.1086/302417 · Cited by 175
Retinoic Acid Promotes Limb Induction through Effects on Body Axis Extension but is Unnecessary for Limb Patterning
Zhao, X.-L., Sirbu, I. O., Mic, F., Molotkova, N., Molotkov, A., Kumar, S., & Duester, G. (2009) · Current Biology · doi:10.1016/j.cub.2009.04.059 · Cited by 178
Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart
Koshiba-Takeuchi, K., Takeuchi, J. K., Arruda, E. P., Kathiriya, I. S., Mo, R., Hui, C.-C., Srivastava, D., & Bruneau, B. G. (2006) · Nature Genetics · doi:10.1038/ng1707 · Cited by 170
Pitx1 determines the morphology of muscle, tendon, and bones of the hindlimb
DeLaurier, A., Schweitzer, R., & Logan, M. P. O. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.06.055 · Cited by 159
Self-citation
Tbx5 and Tbx4 Are Not Sufficient to Determine Limb-Specific Morphologies but Have Common Roles in Initiating Limb Outgrowth
Minguillón, C., Buono, J. D., & Logan, M. P. O. (2005) · Developmental Cell · doi:10.1016/j.devcel.2004.11.013 · Cited by 154
Self-citation
Specific Protein-Protein Interaction between Basic Helix-Loop-Helix Transcription Factors and Homeoproteins of the Pitx Family
Poulin, G. B., Lebel, M., Chamberland, M., Paradis, F., & Drouin, J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4826-4837.2000 · Cited by 152
Asymmetric Lower-Limb Malformations in Individuals with Homeobox PITX1 Gene Mutation
Gurnett, C. A., Alaee, F., Kruse, L. M., Desruisseau, D. M., Hecht, J. T., Wise, C. A., Bowcock, A. M., & Dobbs, M. B. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.10.004 · Cited by 150
Determinants of T box protein specificity
Conlon, F. L., Fairclough, L., Price, B. M. J., Casey, E. S., & Smith, J. C. (2001) · Development · doi:10.1242/dev.128.19.3749 · Cited by 148
Developmental Biology and Human Evolution
Lovejoy, C. O., McCollum, M. A., Reno, P. L., & Rosenman, B. A. (2003) · Annual Review of Anthropology · doi:10.1146/annurev.anthro.32.061002.093223 · Cited by 148
How the embryo makes a limb: determination, polarity and identity
Tickle, C. (2015) · Journal of Anatomy · doi:10.1111/joa.12361 · Cited by 132
DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: The role of HOX genes and physical activity
Turner, D. C., Gorski, P. P., Maasar, M. F., Seaborne, R. A., Baumert, P., Brown, A. D., Kitchen, M. O., Erskine, R. M., Dos-Remedios, I., Voisin, S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-72730-z · Cited by 139
Regulatory evolution and the origin of the bilaterians
Peterson, K. J., & Davidson, E. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4430 · Cited by 139
Genetic and developmental bases of serial homology in vertebrate limb evolution
Ruvinsky, I., & Gibson‐Brown, J. J. (2000) · Development · doi:10.1242/dev.127.24.5233 · Cited by 134
CpG island methylation profiling in human salivary gland adenoid cystic carcinoma
Bell, A., Bell, D., Weber, R. S., & El‐Naggar, A. K. (2011) · Cancer · doi:10.1002/cncr.25818 · Cited by 133
Dlx5 drives Runx2 expression and osteogenic differentiation in developing cranial suture mesenchyme
Holleville, N., Matéos, S., Bontoux, M., Bollérot, K., & Monsoro-Burq, A. H. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.01.003 · Cited by 122
THE COEVOLUTION OF HUMAN HANDS AND FEET
Rolian, C., Lieberman, D. E., & Hallgrímsson, B. (2009) · Evolution · doi:10.1111/j.1558-5646.2009.00944.x · Cited by 121
Molecular genetic cascades for external genitalia formation: An emerging organogenesis program
Yamada, G., Suzuki, K., Haraguchi, R., Miyagawa, S., Satoh, Y., Kamimura, M., Nakagata, N., Kataoka, H., Kuroiwa, A., & Chen, Y. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20807 · Cited by 122
Homeotic Arm-to-Leg Transformation Associated with Genomic Rearrangements at the PITX1 Locus
Spielmann, M., Brancati, F., Krawitz, P. M., Robinson, P. N., Ibrahim, D. M., Franke, M., Hecht, J., Lohan, S. B., Dathe, K., Nardone, A. M., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.08.014 · Cited by 124
Genetics of clubfoot
Dobbs, M. B., & Gurnett, C. A. (2011) · Journal of Pediatric Orthopaedics B · doi:10.1097/bpb.0b013e328349927c · Cited by 114
Developmental origins of precocial forelimbs in marsupial neonates
Keyte, A. L., & Smith, K. K. (2010) · Development · doi:10.1242/dev.049445 · Cited by 110
Regulation of limb bud initiation and limb‐type morphology
Duboc, V., & Logan, M. P. O. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22582 · Cited by 105
Self-citation
Vertebrate aristaless-related genes
Meijlink, F. C. P. W., Beverdam, A., Brouwer, A., Oosterveen, T., & ten Berge, D. (1999) · The International Journal of Developmental Biology · doi:10.1387/ijdb.10668975 · Cited by 105
Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper
Yin, W. H., Wang, Z., Li, Q., Lian, J.-M., Zhou, Y., Lu, B., Jin, L.-J., Qiu, P., Zhang, P., Zhu, W., et al. (2016) · Nature Communications · doi:10.1038/ncomms13107 · Cited by 103
Transcriptional Properties of Ptx1 and Ptx2 Isoforms
Tremblay, J., Goodyer, C. G., & Drouin, J. (2000) · Neuroendocrinology · doi:10.1159/000054547 · Cited by 102
THE COEVOLUTION OF HUMAN HANDS AND FEET
Rolian, C., Lieberman, D. E., & Hallgrímsson, B. (2009) · Evolution · doi:10.1111/j.1558-5646.2010.00944.x · Cited by 156
Vertebrate limb development — the early stages in chick and mouse
Tickle, C. A., & Münsterberg, A. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00220-3 · Cited by 101
Current molecular understanding of Axenfeld–Rieger syndrome
Hjalt, T. Å. H., & Semina, E. V. (2005) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399405010082 · Cited by 100
The Genetic Architecture of Skeletal Convergence and Sex Determination in Ninespine Sticklebacks
Shapiro, M. D., Summers, B. R., Balabhadra, S., Aldenhoven, J., Miller, A. L., Cunningham, C. B., Bell, M. A., & Kingsley, D. M. (2009) · Current Biology · doi:10.1016/j.cub.2009.05.029 · Cited by 98
MORPHOLOGICAL INTEGRATION IN MAMMALIAN LIMB PROPORTIONS: DISSOCIATION BETWEEN FUNCTION AND DEVELOPMENT
Schmidt, M., & Fischer, M. S. (2008) · Evolution · doi:10.1111/j.1558-5646.2008.00583.x · Cited by 96
Analysis of a key regulatory region upstream of theMyf5gene reveals multiple phases of myogenesis, orchestrated at each site by a combination of elements dispersed throughout the locus
Hadchouel, J., Carvajal, J. J., Daubas, P., Bajard, L., Chang, T. H., Rocancourt, D., Cox, D., Summerbell, D., Tajbakhsh, S., Rigby, P. W. J., et al. (2003) · Development · doi:10.1242/dev.00552 · Cited by 95
About face: Signals and genes controlling jaw patterning and identity in vertebrates
Richman, J. M., & Lee, S. (2003) · BioEssays · doi:10.1002/bies.10288 · Cited by 94
Dual hindlimb control elements in theTbx4gene and region-specific control of bone size in vertebrate limbs
Menke, D. B., Guenther, C. A., & Kingsley, D. M. (2008) · Development · doi:10.1242/dev.017384 · Cited by 94
Global Gene Expression Analysis of Murine Limb Development
Taher, L., Collette, N. M., Murugesh, D. K., Maxwell, E. K., Ovcharenko, I., & Loots, G. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028358 · Cited by 92
A Single Pitx1 Binding Site Is Essential for Activity of the LHβ Promoter in Transgenic Mice
Quirk, C. C., Lozada, K. L., Keri, R. A., & Nilson, J. H. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.5.0628 · Cited by 88
Familial Isolated Clubfoot Is Associated with Recurrent Chromosome 17q23.1q23.2 Microduplications Containing TBX4
Alvarado, D. M., Aferol, H., McCall, K., Huang, J. B., Techy, M., Buchan, J. G., Cady, J., Gonzales, P. R., Dobbs, M. B., & Gurnett, C. A. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.06.010 · Cited by 87
Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development
Krause, A., Zacharias, W. J., Camarata, T., Linkhart, B., Law, E. C., Lischke, A., Miljan, E., & Simon, H. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.05.024 · Cited by 85
Tbx4is not required for hindlimb identity or post-bud hindlimb outgrowth
Naiche, L. A., & Papaioannou, V. E. (2006) · Development · doi:10.1242/dev.02712 · Cited by 84
Pitx1 haploinsufficiency causes clubfoot in humans and a clubfoot-like phenotype in mice
Alvarado, D. M., McCall, K., Aferol, H., Silva, M. J., Garbow, J. R., Spees, W. M., Patel, T. K., Siegel, M. J., Dobbs, M. B., & Gurnett, C. A. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr313 · Cited by 83
Molecular shifts in limb identity underlie development of feathered feet in two domestic avian species
Domyan, E. T., Kronenberg, Z. N., Infante, C. R., Vickrey, A. I., Stringham, S. A., Bruders, R., Guernsey, M. W., Park, S., Payne, J. A., Beckstead, R. B., et al. (2016) · eLife · doi:10.7554/elife.12115 · Cited by 83
Testing the effects of FSHD candidate gene expression in vertebrate muscle development.
Wuebbles, R. D., Long, S. W., Hanel, M. L., & Jones, P. L. (2010) · PubMed Central · Cited by 82
Finger or toe: the molecular basis of limb identity
Logan, M. P. O. (2003) · Development · doi:10.1242/dev.00956 · Cited by 81
Self-citation
The contribution of chicken embryology to the understanding of vertebrate limb development
Tickle, C. A. (2004) · Mechanisms of Development · doi:10.1016/j.mod.2004.05.015 · Cited by 80
The genome of the Gulf pipefish enables understanding of evolutionary innovations
Small, C. M., Bassham, S., Catchen, J., Amores, A., Fuiten, A. M., Brown, R. S., Jones, A. G., & Cresko, W. A. (2016) · Genome biology · doi:10.1186/s13059-016-1126-6 · Cited by 82
Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma
Lord, R. V., Brabender, J., Wickramasinghe, K. S., DeMeester, S. R., Hölscher, A. H., Schneider, P. M., Danenberg, P. V., & DeMeester, T. R. (2005) · Surgery · doi:10.1016/j.surg.2005.05.007 · Cited by 77
Neuromancer Tbx20-related genes (H15/midline) promote cell fate specification and morphogenesis of the Drosophila heart
Li, Q., Liu, J., & Bodmer, R. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.01.013 · Cited by 76
A Comparative Molecular Analysis of Developing Mouse Forelimbs and Hindlimbs Using Serial Analysis of Gene Expression (SAGE)Preprint
Margulies, E. H., Kardia, S. L. R., & Innis, J. W. (2001) · Genome Research · doi:10.1101/gr.192601 · Cited by 76
The molecular control of upper extremity development: Implications for congenital hand anomalies
Daluiski, A., Yi, S. E., & Lyons, K. M. (2001) · The Journal Of Hand Surgery · doi:10.1053/jhsu.2001.9419 · Cited by 75
Expression of limb initiation genes and clues to the morphological diversification of threespine stickleback
Cole, N. J., Tanaka, M., Prescott, A., & Tickle, C. (2003) · Current Biology · doi:10.1016/j.cub.2003.11.039 · Cited by 74
Consequences of epigenetic derepression in facioscapulohumeral muscular dystrophy
Greco, A., Goossens, R., van Engelen, B. G. M., & van der Maarel, S. M. (2020) · Clinical Genetics · doi:10.1111/cge.13726 · Cited by 74
Developmental genetic basis for the evolution of pelvic fin loss in the pufferfish Takifugu rubripes
Tanaka, M., Hale, L. A., Amores, A., Yan, Y., Cresko, W. A., Suzuki, T., & Postlethwait, J. H. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.02.016 · Cited by 74
cis‐regulatory mutations are a genetic cause of human limb malformations
VanderMeer, J. E., & Ahituv, N. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22535 · Cited by 76
Pelvic fins in teleosts: structure, function and evolution
Yamanoue, Y., Setiamarga, D. H. E., & Matsuura, K. (2010) · Journal of Fish Biology · doi:10.1111/j.1095-8649.2010.02674.x · Cited by 74
Human syndromes with congenital patellar anomalies and the underlying gene defects
Bongers, E. M., van Kampen, A., van Bokhoven, H., & Knoers, N. V. A. M. (2005) · Clinical Genetics · doi:10.1111/j.1399-0004.2005.00508.x · Cited by 73
Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos
Itou, J., Kawakami, H., Quach, T., Osterwalder, M., Evans, S. Μ., Zeller, R., & Kawakami, Y. (2012) · Development · doi:10.1242/dev.073056 · Cited by 73
Genetics of clubfoot; recent progress and future perspectives
Basit, S., & Khoshhal, K. I. (2017) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2017.09.006 · Cited by 76
Inhibition of xanthine oxidase reduces hyperglycemia-induced oxidative stress and improves mitochondrial alterations in skeletal muscle of diabetic mice
Bravard, A., Bonnard, C., Durand, A., Chauvin, M., Favier, R. J. M., Vidal, H., & Rieusset, J. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00455.2010 · Cited by 72
Pigeonetics takes flight: Evolution, development, and genetics of intraspecific variation
Domyan, E. T., & Shapiro, M. D. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.11.008 · Cited by 73
Deletion of the Pitx1 genomic locus affects mandibular tooth morphogenesis and expression of the Barx1 and Tbx1 genes
Mitsiadis, T. A., & Drouin, J. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.10.055 · Cited by 68
Multiple Regulatory Modules Are Required for Scale-to-Feather Conversion
Wu, P., Yan, J., Lai, Y., Ng, C. S., Li, A., Jiang, X., Elsey, R. M., Widelitz, R. B., Bajpai, R., Li, W., et al. (2017) · Molecular Biology and Evolution · doi:10.1093/molbev/msx295 · Cited by 68
FGF and genes encoding transcription factors in early limb specification
Isaac, A., Cohn, M. J., Ashby, P. R., Ataliotis, P., Spicer, D. B., Cooke, J., & Tickle, C. A. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00261-6 · Cited by 67
Functional conservation of the wingless–engrailed interaction as shown by a widely applicable baculovirus misexpression system
Oppenheimer, D. I., MacNicol, A. M., & Patel, N. H. (1999) · Current Biology · doi:10.1016/s0960-9822(00)80050-0 · Cited by 64
Pitx1 is necessary for normal initiation of hindlimb outgrowth through regulation of Tbx4 expression and shapes hindlimb morphologies via targeted growth control
Duboc, V., & Logan, M. P. O. (2011) · Development · doi:10.1242/dev.074153 · Cited by 62
Self-citation
A Combination of Activation and Repression by a Colinear Hox Code Controls Forelimb-Restricted Expression of Tbx5 and Reveals Hox Protein Specificity
Nishimoto, S., Minguillón, C., Wood, S., & Logan, M. P. O. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004245 · Cited by 61
Self-citation
A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing
Long, S. W., Ooi, J. Y. Y., Yau, P. M., & Jones, P. L. (2010) · Bioscience Reports · doi:10.1042/bsr20100124 · Cited by 62
Pitx1 broadly associates with limb enhancers and is enriched on hindlimb cis-regulatory elements
Infante, C. R., Park, S., Mihala, A. G., Kingsley, D. M., & Menke, D. B. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.11.017 · Cited by 60
A Perspective on Micro-Evo-Devo: Progress and Potential
Nunes, M. D. S., Arif, S., Schlötterer, C., & McGregor, A. P. (2013) · Genetics · doi:10.1534/genetics.113.156463 · Cited by 57
Pitx2 in Embryonic and Adult Myogenesis
Hernández‐Torres, F., Rodríguez-Outeiriño, L., Franco, D., & Aránega, A. E. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00046 · Cited by 60
Different Regulation of T-Box Genes Tbx4 and Tbx5 during Limb Development and Limb Regeneration
Khan, P., Linkhart, B., & Simon, H. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0801 · Cited by 58
Divergent transcriptional activities determine limb identity
Ouimette, J., Lavertu-Jolin, M., L’honoré, A., Gifuni, A. J., & Drouin, J. (2010) · Nature Communications · doi:10.1038/ncomms1036 · Cited by 56
Selector Genes and Limb Identity in Arthropods and Vertebrates
Weatherbee, S. D., & Carroll, S. B. (1999) · Cell · doi:10.1016/s0092-8674(00)80737-0 · Cited by 56
Regulation of Mandibular Growth and Morphogenesis
Mina, M. (2001) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411010120040101 · Cited by 55
Conservation of linkage and evolution of developmental function within the Tbx2/3/4/5 subfamily of T-box genes: implications for the origin of vertebrate limbs
Horton, A. C., Mahadevan, N. R., Minguillón, C., Osoegawa, K., Rokhsar, D. S., Ruvinsky, I., de Jong, P. J., Logan, M. P. O., & Gibson‐Brown, J. J. (2008) · Development Genes and Evolution · doi:10.1007/s00427-008-0249-5 · Cited by 55
Self-citation
Conditional over-expression of PITX1 causes skeletal muscle dystrophy in mice
Pandey, S. N., Cabotage, J., Shi, R., Dixit, M., Sutherland, M., Liu, J., Muger, S., Harper, S. Q., Nagaraju, K., & Chen, Y. (2012) · Biology Open · doi:10.1242/bio.20121305 · Cited by 54

Authors: Logan, M., & Tabin, C. J.
Affiliations: Harvard University (US)
Corresponding author: Tabin, Clifford J.
ORCID: Logan, Malcolm
Tabin, Clifford J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1999-03-12
Volume: 283
Issue: 5408
Pages: 1736-1739
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.283.5408.1736
OpenAlex: W2042190289
Cited by: 304
References: 22
Citations by year: 2026: 5 · 2025: 9 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 15 · 2020: 11 · 2019: 11 · 2018: 6 · 2017: 16 · 2016: 12 · 2015: 9 · 2014: 6 · 2013: 14 · 2012: 14
FWCI: 7.35
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Developmental Biology › Congenital limb and hand anomalies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords: PITX1, TBX4, limb patterning, chick wing bud, HOXC10, HOXC11, transcription factors, digit morphology
MeSH terms: Animals, Chick Embryo, Ectoderm, Feathers, Foot, Genetic Vectors, Hindlimb, Mesoderm, Retroviridae, Transcription Factors, Wings, Animal, Cell Death, Homeodomain Proteins, Muscle, Skeletal, Gene Expression Regulation, Developmental, Limb Buds, Body Patterning, T-Box Domain Proteins, Avian Proteins, Paired Box Transcription Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of Pitx1 Upstream of Tbx4 in Specification of Hindlimb Identity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks