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Negative Regulation of Wingless Signaling by D-Axin, a Drosophila Homolog of Axin
Abstract
Wnt/Wingless directs many cell fates during development. Wnt/Wingless signaling increases the amount of β-catenin/Armadillo, which in turn activates gene transcription. Here the Drosophila protein D-Axin was shown to interact with Armadillo and D-APC. Mutation of d-axin resulted in the accumulation of cytoplasmic Armadillo and one of the Wingless target gene products, Distal-less. Ectopic expression of d-axin inhibited Wingless signaling. Hence, D-Axin negatively regulates Wingless signaling by down-regulating the level of Armadillo. These results establish the importance of the Axin family of proteins in Wnt/Wingless signaling in Drosophila .
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Cites
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
Cited by
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00224-6 · Cited by 839
Mutations and mechanisms of WNT pathway tumour suppressors in cancer
Bugter, J. M., Fenderico, N., & Maurice, M. M. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-020-00307-z · Cited by 466
Akiyama, T. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00011-3 · Cited by 425
Self-citationWharton, K. A. (2003) · Developmental Biology · doi:10.1006/dbio.2002.0869 · Cited by 315
Metadata
- Authors
- Hamada, F., Tomoyasu, Y., Takatsu, Y., Nakamura, M., Nagai, S.-I., Suzuki, A., Fujita, F., Shibuya, H., Toyoshima, K., Ueno, N., & Akiyama, T.
- Venue
- Science
- Published
- 1999-03-12
- Volume
- 283
- Issue
- 5408
- Pages
- 1739-1742
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2105571987
- Cited by
- 197
- References
- 1
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hamada, F., Tomoyasu, Y., Takatsu, Y., Nakamura, M., Nagai, S.-I., Suzuki, A., Fujita, F., Shibuya, H., Toyoshima, K., Ueno, N., & Akiyama, T. (1999). Negative Regulation of Wingless Signaling by D-Axin, a Drosophila Homolog of Axin. Science. https://doi.org/10.1126/science.283.5408.1739
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
