Runnin' with the Dvl: Proteins That Associate with Dsh/Dvl and Their Significance to Wnt Signal Transduction

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Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

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GTPase-Activating Proteins for Heterotrimeric G Proteins: Regulators of G Protein Signaling (RGS) and RGS-Like Proteins

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An LDL-receptor-related protein mediates Wnt signalling in mice

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AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

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The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

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arrow encodes an LDL-receptor-related protein essential for Wingless signalling

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Wnt/Frizzled Activation of Rho Regulates Vertebrate Gastrulation and Requires a Novel Formin Homology Protein Daam1

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Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway

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Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

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Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathwayPreprint

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Dishevelled controls cell polarity during Xenopus gastrulation

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Flamingo, a Seven-Pass Transmembrane Cadherin, Regulates Planar Cell Polarity under the Control of Frizzled

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PDZ Domains: Structural Modules for Protein Complex Assembly

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Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathwaysPreprint

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Drosophila Rho-Associated Kinase (Drok) Links Frizzled-Mediated Planar Cell Polarity Signaling to the Actin Cytoskeleton

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Mechanisms of convergence and extension by cell intercalation

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Ca2+/Calmodulin-dependent Protein Kinase II Is Stimulated by Wnt and Frizzled Homologs and Promotes Ventral Cell Fates in Xenopus

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Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail

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Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements

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Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

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Protein kinase CK2: a challenge to canons

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Axin, a Negative Regulator of the Wnt Signaling Pathway, Directly Interacts with Adenomatous Polyposis Coli and Regulates the Stabilization of β-Catenin

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Prickle Mediates Feedback Amplification to Generate Asymmetric Planar Cell Polarity Signaling

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Casein kinase I transduces Wnt signals

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Planar Signaling and Morphogenesis in Drosophila

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EPS8 and E3B1 transduce signals from Ras to Rac

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GBP, an Inhibitor of GSK-3, Is Implicated in Xenopus Development and Oncogenesis

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The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos

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Axin, an inhibitor of the Wnt signalling pathway, interacts with β‐catenin, GSK‐3β and APC and reduces the β‐catenin level

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Dishevelled Proteins Lead to Two Signaling Pathways

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The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5

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The balance between isoforms of the Prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discsPreprint

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Domains of Axin Involved in Protein–Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization

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PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

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Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer

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G Protein Signaling from Activated Rat Frizzled-1 to the β-Catenin-Lef-Tcf Pathway

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LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way

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Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

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Dishevelled: The hub of Wnt signaling

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Wnt and calcium signaling: β-Catenin-independent pathways

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WNTS in the vertebrate nervous system: from patterning to neuronal connectivity

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β-Catenin destruction complex: insights and questions from a structural perspective

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Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

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Direct Binding of the PDZ Domain of Dishevelled to a Conserved Internal Sequence in the C-Terminal Region of Frizzled

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The Wnt signaling pathway and its role in tumor development

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The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity

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Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions

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Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

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The KLHL12–Cullin-3 ubiquitin ligase negatively regulates the Wnt–β-catenin pathway by targeting Dishevelled for degradation

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Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos

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Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression

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Wnt/Notch signalling and information processing during development

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Multiplicity of the interactions of Wnt proteins and their receptors

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The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

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New Insights into the Mechanism of Wnt Signaling Pathway Activation

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Wnt signaling in lung cancer

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Maternal factors in zebrafish development

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An Antagonist of Dishevelled Protein-Protein Interaction Suppresses β-Catenin–Dependent Tumor Cell Growth

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Dynamic recruitment of axin by Dishevelled protein assemblies

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Dishevelled: A masterful conductor of complex Wnt signals

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Wnt/beta-Catenin Signaling and Small Molecule Inhibitors

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The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles

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Dishevelled and Wnt signaling: is the nucleus the final frontier?

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Canonical Wnt activity regulates trunk neural crest delamination linking BMP/noggin signaling with G1/S transition

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RNA Helicase DDX3 Is a Regulatory Subunit of Casein Kinase 1 in Wnt–β-Catenin Signaling

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Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex

Foley, A. C., & Mercola, M. (2005) · Genes &amp; Development · doi:10.1101/gad.1279405 · Cited by 195 · see citing works

NONCANONICAL WNT SIGNALING AND NEURAL POLARITY

Montcouquiol, M., Crenshaw, E. B., & Kelley, M. W. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112933 · Cited by 191 · see citing works

The Wnt connection to tumorigenesis

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Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases

Jiang, X., Charlat, O., Zamponi, R., Yang, Y., & Cong, F. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.015 · Cited by 192 · see citing works

Activation of the Canonical Wingless/T-Cell Factor Signaling Pathway Promotes Invasive Differentiation of Human Trophoblast

Pollheimer, J., Loregger, T., Sonderegger, S., Saleh, L., Bauer, S., Bilban, M., Czerwenka, K. F., Husslein, P. W., & Knöfler, M. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050686 · Cited by 192 · see citing works

DEP-Domain-Mediated Regulation of GPCR Signaling Responses

Ballon, D. R., Flanary, P. L., Gladue, D. P., Konopka, J. B., Dohlman, H. G., & Thorner, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.07.030 · Cited by 189 · see citing works

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

Bryja, V., Schulte, G., Rawal, N., Grahn, A., & Arenas, E. (2007) · Journal of Cell Science · doi:10.1242/jcs.03368 · Cited by 186 · see citing works

Wnt Proteins Induce Dishevelled Phosphorylation via an LRP5/6- Independent Mechanism, Irrespective of Their Ability To Stabilize β-Catenin

González‐Sancho, J. M., Brennan, K. R., Castelo‐Soccio, L. A., & Brown, A. M. C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.11.4757-4768.2004 · Cited by 182 · see citing works

Evolution of the Wnt Pathways

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NEDL1, a Novel Ubiquitin-protein Isopeptide Ligase for Dishevelled-1, Targets Mutant Superoxide Dismutase-1

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PKCδ is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movementsPreprint

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Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish developmentPreprint

Matsui, T., Raya, Á., Kawakami, Y., Callol-Massot, C., Capdevila, J., Rodrı́guez-Esteban, C., & Belmonte, J. C. I. (2005) · Genes & Development · doi:10.1101/gad.1253605 · Cited by 167 · see citing works

Inhibition of Wnt signaling by Dishevelled PDZ peptides

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Dapper 1 Antagonizes Wnt Signaling by Promoting Dishevelled Degradation

Zhang, L., Gao, X., Wen, J., Ning, Y., & Chen, Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600274200 · Cited by 156 · see citing works

The role of the Wnt signalling pathway in colorectal tumorigenesis

Behrens, J. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330672 · Cited by 153 · see citing works

Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK

Unterseher, F., Hefele, J. A., Giehl, K., Robertis, E. M. D., Wedlich, D., & Schambony, A. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600332 · Cited by 153 · see citing works

Winding through the WNT pathway during cellular development and demise.

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Multiple Wnt Signaling Pathways Converge to Orient the Mitotic Spindle in Early C. elegans Embryos

Walston, T., Tuskey, C., Edgar, L. G., Hawkins, N., Ellis, G. C., Bowerman, B. A., Wood, W. B., & Hardin, J. D. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.10.008 · Cited by 144 · see citing works

Differential stability of β-catenin along the animal-vegetal axis of the sea urchin embryo mediated by dishevelled

Weitzel, H. E., Illies, M. R., Byrum, C. A., Xu, R., Wikramanayake, A. H., & Ettensohn, C. A. (2004) · Development · doi:10.1242/dev.01152 · Cited by 141 · see citing works

Prickle-1 Negatively Regulates Wnt/β-Catenin Pathway by Promoting Dishevelled Ubiquitination/Degradation in Liver Cancer

Chan, D. W., Chan, C., Yam, J. W. P., Ching, Y., & Ng, I. O. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.07.020 · Cited by 135 · see citing works

β-Arrestin is a necessary component of Wnt/β-catenin signaling in vitro and in vivo

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Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3

Lee, Y.-N., Gao, Y., & Wang, H. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.11.005 · Cited by 133 · see citing works

Wnts induce migration and invasion of myeloma plasma cells

Qiang, Y. (2005) · Blood · doi:10.1182/blood-2005-01-0049 · Cited by 134 · see citing works

Regulation of the Wnt signaling pathway by disabled‐2 (Dab2)

Hocevar, B. A., Mou, F., Rennolds, J., Morris, S. M., Cooper, J. A., & Howe, P. H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg286 · Cited by 134 · see citing works

The β-Catenin/T-Cell Factor/Lymphocyte Enhancer Factor Signaling Pathway Is Required for Normal and Stress-Induced Cardiac Hypertrophy

Chen, X., Shevtsov, S. P., Hsich, E., Cui, L., Haq, S., Aronovitz, M. J., Kerkelä, R., Molkentin, J. D., Liao, R., Salomon, R., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02157-05 · Cited by 131 · see citing works

Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin

Henríquez, J. P., Webb, A., Bence, M., Bildsoe, H., Sahores, M., Hughes, S. M., & Salinas, P. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806300105 · Cited by 129 · see citing works

Wnt signaling activation during bone regeneration and the role of Dishevelled in chondrocyte proliferation and differentiation

Zhong, N., Gersch, R. P., & Hadjiargyrou, M. (2006) · Bone · doi:10.1016/j.bone.2005.12.008 · Cited by 129 · see citing works

Wnt-3a and Dvl Induce Neurite Retraction by Activating Rho-Associated Kinase

Kishida, S., Yamamoto, H., & Kikuchi, A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4487-4501.2004 · Cited by 129 · see citing works

Osteocytes and WNT: the Mechanical Control of Bone Formation

Galli, C., Passeri, G., & Macaluso, G. M. (2010) · Journal of Dental Research · doi:10.1177/0022034510363963 · Cited by 127 · see citing works

The canonical Wnt pathway in early mammalian embryogenesis and stem cell maintenance/differentiation

Wang, J., & Wynshaw-Boris, A. J. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.07.013 · Cited by 127 · see citing works

Binding of APC and dishevelled mediates Wnt5a‐regulated focal adhesion dynamics in migrating cells

Matsumoto, S., Fumoto, K., Okamoto, T., Kaibuchi, K., & Kikuchi, A. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.26 · Cited by 118 · see citing works

Transcriptional Profiling of the Heart Reveals Chamber-Specific Gene Expression Patterns

Tabibiazar, R., Wagner, R. A., Liao, A. K., & Quertermous, T. (2003) · Circulation Research · doi:10.1161/01.res.0000103171.42654.dd · Cited by 116 · see citing works

Tumor formation due to abnormalities in the β‐catenin‐independent pathway of Wnt signaling

Kikuchi, A., & Yamamoto, H. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2007.00675.x · Cited by 115 · see citing works

Interruption of Wnt Signaling Attenuates the Onset of Pressure Overload-Induced Cardiac Hypertrophy

van de Schans, V. A. M., van den Borne, S. W. M., Strzelecka‐Kiliszek, A., Janssen, B. J., van der Velden, J. L. J., LANGEN, R. C. J., Boris, A. W., Smits, J. F. M., & Blankesteijn, W. M. (2007) · Hypertension · doi:10.1161/01.hyp.0000255946.55091.24 · Cited by 115 · see citing works

SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling

Holloway, K. R., Calhoun, T. N., Saxena, M., Metoyer, C. F., Kandler, E. F., Rivera, C. A., & Pruitt, K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911325107 · Cited by 115 · see citing works

Distinct PAR-1 Proteins Function in Different Branches of Wnt Signaling during Vertebrate Development

Ossipova, O., Dhawan, S., Sokol, S., & Green, J. B. A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.04.011 · Cited by 113 · see citing works

The many roles of PTK7: A versatile regulator of cell–cell communication

Peradziryi, H., Tolwinski, N. S., & Borchers, A. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.12.019 · Cited by 111 · see citing works

Sequential Activation and Inactivation of Dishevelled in the Wnt/β-Catenin Pathway by Casein Kinases

Bernatík, O., Ganji, R. S., Dijksterhuis, J. P., Koník, P., Červenka, I., Polonio, T., Krejčı́, P., Schulte, G., & Bryja, V. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.169870 · Cited by 108 · see citing works

Nucleoredoxin, a Novel Thioredoxin Family Member Involved in Cell Growth and Differentiation

Funato, Y., & Miki, H. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1550 · Cited by 114 · see citing works

Wnt Signaling: Physiology and Pathology

Prunier, C., Hocevar, B. A., & Howe, P. H. (2004) · Growth Factors · doi:10.1080/08977190410001720860 · Cited by 108 · see citing works

Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis

Li, Y., Zhang, H., Choi, S. C., Litingtung, Y., & Chiang, C. C. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.03.009 · Cited by 107 · see citing works

Inhibition of the Wnt/β-catenin pathway by the WWOX tumor suppressor protein

Bouteille, N. K., Driouch, K., Hage, P. E., Sin, S., Formstecher, É., Camonis, J., Lidereau, R., & Lallemand, F. (2009) · Oncogene · doi:10.1038/onc.2009.120 · Cited by 106 · see citing works

JNK and ROKα function in the noncanonical Wnt/RhoA signaling pathway to regulate Xenopus convergent extension movements

Kim, G., & Han, J. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20262 · Cited by 103 · see citing works

Dishevelled: A Mobile Scaffold Catalyzing Development

Malbon, C. C., & Wang, H. (2005) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)72002-0 · Cited by 105 · see citing works

Dishevelled 2 Signaling Promotes Self-Renewal and Tumorigenicity in Human Gliomas

Pulvirenti, T., van der Heijden, M., Droms, L. A., Huse, J. T., Tabar, V. S., & Hall, A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1531 · Cited by 103 · see citing works

Canonical Wnt Signaling is Necessary for Object Recognition Memory Consolidation

Fortress, A. M., Schram, S., Tuscher, J. J., & Frick, K. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0659-13.2013 · Cited by 100 · see citing works

LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse

Sakane, H., Yamamoto, H., & Kikuchi, A. (2010) · Journal of Cell Science · doi:10.1242/jcs.058008 · Cited by 98 · see citing works

Localization of glypican-4 in different membrane microdomains is involved in the regulation of Wnt signaling

Sakane, H., Yamamoto, H., Matsumoto, S., Sato, A., & Kikuchi, A. (2012) · Journal of Cell Science · doi:10.1242/jcs.091876 · Cited by 96 · see citing works

The various roles of ubiquitin in Wnt pathway regulation

Tauriello, D. V. F., & Maurice, M. M. (2010) · Cell Cycle · doi:10.4161/cc.9.18.13204 · Cited by 95 · see citing works

Vital Elements of the Wnt-Frizzled Signaling Pathway in the Nervous System

Li, F., Chong, Z. Z., & Maiese, K. (2005) · Current Neurovascular Research · doi:10.2174/156720205774322557 · Cited by 91 · see citing works

RanBP3 enhances nuclear export of active β-catenin independently of CRM1

Hendriksen, J., Fagotto, F., van der Velde, H., van Schie, M., Noordermeer, J. N., & Fornerod, M. W. J. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200502141 · Cited by 91 · see citing works

Molecular regulation of kidney development: is the answer blowing in the Wnt?

Merkel, C. E., Karner, C. M., & Carroll, T. J. (2007) · Pediatric Nephrology · doi:10.1007/s00467-007-0504-4 · Cited by 89 · see citing works

The ins and outs of Wingless signaling

Seto, E., & Bellen, H. J. (2003) · Trends in Cell Biology · doi:10.1016/j.tcb.2003.11.004 · Cited by 89 · see citing works

The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility

Takagishi, M., Enomoto, A., Asai, N., Ushida, K., Watanabe, T., Hashimoto, T., Kato, T., Weng, L., Matsumoto, S., Asai, M., et al. (2012) · Nature Communications · doi:10.1038/ncomms1861 · Cited by 84 · see citing works

Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes

Waxman, J. S., Hocking, A. M., Stoick-Cooper, C. L., & Moon, R. T. (2004) · Development · doi:10.1242/dev.01520 · Cited by 87 · see citing works

Development of anticancer agents targeting the Wnt/β-catenin signaling.

Zhang, X., & Hao, J. (2015) · Europe PMC (PubMed Central) · Cited by 85 · see citing works

Gαo mediates WNT-JNK signaling through Dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells

Bikkavilli, R. K., Feigin, M. E., & Malbon, C. C. (2008) · Journal of Cell Science · doi:10.1242/jcs.021964 · Cited by 85 · see citing works

Dishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1

Kikuchi, K., Niikura, Y., Kitagawa, K., & Kikuchi, A. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.221 · Cited by 80 · see citing works

Wnt/Frizzled Signaling during Vertebrate Retinal Development

Raay, T. J. V., & Vetter, M. L. (2004) · Developmental Neuroscience · doi:10.1159/000082277 · Cited by 80 · see citing works

Requirement for intracellular calcium modulation in zebrafish dorsal–ventral patterning

Westfall, T. A., Hjertos, B., & Slusarski, D. C. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00209-4 · Cited by 80 · see citing works

Wnt signaling and neural stem cells: caught in the Wnt web

Michaelidis, T. M., & Lie, D. C. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0476-5 · Cited by 80 · see citing works

An analysis of the gene expression program of mammalian neural progenitor cells

Livesey, F. J., Young‐Pearse, T. L., & Cepko, C. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307014101 · Cited by 78 · see citing works

Sequence Similarity Network Reveals Common Ancestry of Multidomain Proteins

Song, N., Joseph, J. M., Davis, G. B., & Durand, D. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000063 · Cited by 76 · see citing works

Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway

Pérez‐Plasencia, C., Dueñas‐González, A., & Alatorre, B. (2008) · International Archives of Medicine · doi:10.1186/1755-7682-1-10 · Cited by 78 · see citing works

Developing a sense of taste

Kapsimali, M., & Barlow, L. A. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.11.002 · Cited by 76 · see citing works

Endocytosis, Endosome Trafficking, and the Regulation ofDrosophilaDevelopment

Fischer, J. A., Eun, S. H., & Doolan, B. T. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010605.093205 · Cited by 76 · see citing works

PR72, a novel regulator of Wnt signaling required for Naked cuticle functionPreprint

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Nucleotide variants of genes encoding components of the Wnt signalling pathway and the risk of non‐syndromic tooth agenesis

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