The DOI matches its Crossref record.
Activation of Cell-Specific Expression of Rat Growth Hormone and Prolactin Genes by a Common Transcription Factor
Abstract
In the anterior pituitary gland, there are five phenotypically distinct cell types, including cells that produce either prolactin (lactotrophs) or growth hormone (somatotrophs). Multiple, related cis-active elements that exhibit synergistic interactions appear to be the critical determinants of the transcriptional activation of the rat prolactin and growth hormone genes. A common positive tissue-specific transcription factor, referred to as Pit-1, appears to bind to all the cell-specific elements in each gene and to be required for the activation of both the prolactin and growth hormone genes. The data suggest that, in the course of development, a single tissue-specific factor activates sets of genes that ultimately exhibit restricted cell-specific expression and define cellular phenotype.
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Cited by
Klemm, J. D., Rould, M. A., Aurora, R., Herr, W., & Pabo, C. O. (1994) · Cell · doi:10.1016/0092-8674(94)90231-3 · Cited by 506
Herr, W., & Cleary, M. A. (1995) · Genes & Development · doi:10.1101/gad.9.14.1679 · Cited by 388
Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter
Bossé, R., Fumagalli, F., Jaber, M., Giros, B., Gainetdinov, R. R., Wetsel, W. C., Missale, C., & Caron, M. G. (1997) · Neuron · doi:10.1016/s0896-6273(00)80353-0 · Cited by 203
Metadata
- Authors
- Nelson, C., Albert, V. R., Elsholtz, H. P., Lu, L. I.-W., & Rosenfeld, M. G.
- Venue
- Science
- Published
- 1988-03-18
- Volume
- 239
- Issue
- 4846
- Pages
- 1400-1405
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2052366220
- Cited by
- 513
- References
- 0
- FWCI
- 19.57
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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