The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Regulation of Maternal Behavior and Offspring Growth by Paternally Expressed Peg3
Abstract
Imprinted genes display parent-of-origin–dependent monoallelic expression that apparently regulates complex mammalian traits, including growth and behavior. The Peg3 gene is expressed in embryos and the adult brain from the paternal allele only. A mutation in the Peg3 gene resulted in growth retardation, as well as a striking impairment of maternal behavior that frequently resulted in death of the offspring. This result may be partly due to defective neuronal connectivity, as well as reduced oxytocin neurons in the hypothalamus, because mutant mothers were deficient in milk ejection. This study provides further insights on the evolution of epigenetic regulation of imprinted gene dosage in modulating mammalian growth and behavior.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Completion of mouse embryogenesis requires both the maternal and paternal genomes
McGrath, J., & Solter, D. (1984) · Cell · doi:10.1016/0092-8674(84)90313-1 · Cited by 1,571
Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis
Surani, M. A. H., Barton, S. C., & Norris, M. L. (1984) · Nature · doi:10.1038/308548a0 · Cited by 1,430
Self-citationGenomic imprinting in mammalian development: a parental tug-of-war
Moore, T. (1991) · Trends in Genetics · doi:10.1016/0168-9525(91)90230-n · Cited by 1,281
Pedersen, C. A., & Prange, A. J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.12.6661 · Cited by 841
Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.
Nishimori, K., Young, L. J., Guo, Q., Wang, Z., Insel, T. R., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11699 · Cited by 734
A Defect in Nurturing in Mice Lacking the Immediate Early Gene fosB
Brown, J. R., Ye, H., Bronson, R. T., Dikkes, P., & Greenberg, M. E. (1996) · Cell · doi:10.1016/s0092-8674(00)80101-4 · Cited by 339
Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition
Young III, W. S., Shepard, E., Amico, J., Hennighausen, L., Wagner, K., LaMarca, M. E., McKinney, C., & Ginns, E. I. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.05266.x · Cited by 308
van Leengoed, E., Kerker, E., & Swanson, H. H. (1987) · Journal of Endocrinology · doi:10.1677/joe.0.1120275 · Cited by 300
Peg1/Mest imprinted gene on chromosome 6 identified by cDNA subtraction hybridization
Kaneko-Ishino, T., Kuroiwa, Y., Miyoshi, N., Kohda, T., Suzuki, R., Yokoyama, M., Viville, S., Barton, S. C., Ishino, F., & Surani, M. A. (1995) · Nature Genetics · doi:10.1038/ng0995-52 · Cited by 283
Self-citationGenomic imprinting and the differential roles of parental genomes in brain development
Keverne, E. B., Fundele, R., Narasimha, M., Barton, S. C., & Surani, M. A. (1996) · Developmental Brain Research · doi:10.1016/0165-3806(95)00209-x · Cited by 215
Self-citation
Cited by
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
The history of cancer epigenetics
Feinberg, A. P., & Tycko, B. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1279 · Cited by 2,344
Genomic imprinting: parental influence on the genome
Reik, W., & Walter, J. (2001) · Nature Reviews Genetics · doi:10.1038/35047554 · Cited by 2,285
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059
Placental-specific IGF-II is a major modulator of placental and fetal growth
Constância, M., Hemberger, M., Hughes, J., Dean, W., Ferguson-Smith, A., Fundele, R., Stewart, F., Kelsey, G., Fowden, A., Sibley, C., et al. (2002) · Nature · doi:10.1038/nature00819 · Cited by 1,054
Metadata
- Authors
- Li, L.-L., Keverne, E. B., Aparicio, S. A., Ishino, F., Barton, S. C., & Surani, M. A.
- Venue
- Science
- Published
- 1999-04-09
- Volume
- 284
- Issue
- 5412
- Pages
- 330-334
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1981849389
- Cited by
- 511
- References
- 24
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Regulation of Maternal Behavior and Offspring Growth by Paternally Expressed Peg3. https://app.cochat.ai/papers/10.1126/science.284.5412.330
- The paper
- Li, L.-L., Keverne, E. B., Aparicio, S. A., Ishino, F., Barton, S. C., & Surani, M. A. (1999). Regulation of Maternal Behavior and Offspring Growth by Paternally Expressed Peg3. Science. https://doi.org/10.1126/science.284.5412.330
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
