The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity
Abstract
T cell receptor (TCR) signaling requires activation of Zap-70 and Src family tyrosine kinases, but requirements for other tyrosine kinases are less clear. Combined deletion in mice of two Tec kinases, Rlk and Itk, caused marked defects in TCR responses including proliferation, cytokine production, and apoptosis in vitro and adaptive immune responses to Toxoplasma gondii in vivo. Molecular events immediately downstream from the TCR were intact in rlk −/− itk −/− cells, but intermediate events including inositol trisphosphate production, calcium mobilization, and mitogen-activated protein kinase activation were impaired, establishing Tec kinases as critical regulators of TCR signaling required for phospholipase C–γ activation.
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Cites
Signal transduction by lymphocyte antigen receptors
Weiss, A., & Littman, D. R. (1994) · Cell · doi:10.1016/0092-8674(94)90334-4 · Cited by 2,089
Self-citationProtein kinase Cα activates RAF-1 by direct phosphorylation
Kolch, W., Heidecker, G., Kochs, G., Hummel, R., Vahidi, H., Mischak, H., Finkenzeller, G., Marmé, D., & Rapp, U. R. (1993) · Nature · doi:10.1038/364249a0 · Cited by 1,277
Zhang, W., Sloan-Lancaster, J., Kitchen, J., Trible, R. P., & Samelson, L. E. (1998) · Cell · doi:10.1016/s0092-8674(00)80901-0 · Cited by 1,267
Straus, D. (1992) · Cell · doi:10.1016/0092-8674(92)90428-f · Cited by 1,034
Sloan-Lancaster, J., & Allen, P. M. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.1 · Cited by 676
T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS
Cantrell, D. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.259 · Cited by 674
Complex Complexes: Signaling at the TCR
Wange, R. L., & Samelson, L. E. (1996) · Immunity · doi:10.1016/s1074-7613(00)80315-5 · Cited by 511
Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell
Yablonski, D., Kuhne, M. R., Kadlecek, T., & Weiss, A. (1998) · Science · doi:10.1126/science.281.5375.413 · Cited by 412
Liu, K.-Q., Bunnell, S. C., Gurniak, C. B., & Berg, L. J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.10.1721 · Cited by 339
Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk
Liao, X. C., & Littman, D. R. (1995) · Immunity · doi:10.1016/1074-7613(95)90065-9 · Cited by 315
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Cited by
Regulation of Phosphoinositide-Specific Phospholipase C
Rhee, S. G. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.281 · Cited by 1,628
Molecular Mechanisms RegulatinG Th1 Immune Responses
Szabo, S. J., Sullivan, B. M., Peng, S. L., & Glimcher, L. H. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.140942 · Cited by 1,019
Dubovsky, J. A., Beckwith, K. A., Natarajan, G., Woyach, J. A., Jaglowski, S., Zhong, Y., Hessler, J. D., Liu, T.-M., Chang, B. Y., Larkin, K. M., et al. (2013) · Blood · doi:10.1182/blood-2013-06-507947 · Cited by 810
T-Cell Signaling Regulated by the Tec Family Kinase, Itk
Andreotti, A. H., Schwartzberg, P. L., Joseph, R. E., & Berg, L. J. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002287 · Cited by 593
Self-citationSignal Transduction Mediated by the T Cell Antigen Receptor: The Role of Adapter Proteins
Samelson, L. E. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.092601.111357 · Cited by 573
Metadata
- Authors
- Schaeffer, E. M., Debnath, J., Yap, G., McVicar, D., Liao, X. C., Littman, D. R., Sher, A., Varmus, H. E., Lenardo, M. J., & Schwartzberg, P. L.
- Venue
- Science
- Published
- 1999-04-23
- Volume
- 284
- Issue
- 5414
- Pages
- 638-641
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2053463045
- Cited by
- 398
- References
- 22
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schaeffer, E. M., Debnath, J., Yap, G., McVicar, D., Liao, X. C., Littman, D. R., Sher, A., Varmus, H. E., Lenardo, M. J., & Schwartzberg, P. L. (1999). Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity. Science. https://doi.org/10.1126/science.284.5414.638
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
