The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.
T-Cell Signaling Regulated by the Tec Family Kinase, Itk
Open accessAbstract
The Tec family tyrosine kinases regulate lymphocyte development, activation, and differentiation. In T cells, the predominant Tec kinase is Itk, which functions downstream of the T-cell receptor to regulate phospholipase C-gamma. This review highlights recent advances in our understanding of Itk kinase structure and enzymatic regulation, focusing on Itk protein domain interactions and mechanisms of substrate recognition. We also discuss the role of Itk in the development of conventional versus innate T-cell lineages, including both alphabeta and gammadelta T-cell subsets. Finally, we describe the complex role of Itk signaling in effector T-cell differentiation and the regulation of cytokine gene expression. Together, these data implicate Itk as an important modulator of T-cell signaling and function.
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“Thus, TCR signaling may be particularly important for expression of IL-17A, which is more strongly proinflammatory than IL-17F (Yang et al. 2008; Ishigame et al. 2009).”
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Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism.
Schauer, N. J., Liu, X., Magin, R. S., Doherty, L. M., Chan, W. C., Ficarro, S. B., Hu, W., Roberts, R. M., Iacob, R. E., Stolte, B., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-62076-x · Cited by 125
Metadata
- Authors
- Andreotti, A. H., Schwartzberg, P. L., Joseph, R. E., & Berg, L. J.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-06-02
- Volume
- 2
- Issue
- 7
- Pages
- a002287-a002287
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2135163046
- Cited by
- 593
- References
- 131
- Type
- posted content
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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