Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection
Abstract
Viral clearance during hepatitis B virus (HBV) infection has been thought to reflect the destruction of infected hepatocytes by CD8 + T lymphocytes. However, in this study, HBV DNA was shown to largely disappear from the liver and the blood of acutely infected chimpanzees long before the peak of T cell infiltration and most of the liver disease. These results demonstrate that noncytopathic antiviral mechanisms contribute to viral clearance during acute viral hepatitis by purging HBV replicative intermediates from the cytoplasm and covalently closed circular viral DNA from the nucleus of infected cells.
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Following presentation of viral antigens coupled to MHC class I molecules by infected hepatocytes, virus-specific CTLs clear hepatitis viruses by both cytolytic and non-cytolytic effector functions.
“Following presentation of viral antigens coupled to MHC class I molecules by infected hepatocytes, virus-specific CTLs are able to clear hepatitis viruses by means of both cytolytic and non-cytolytic effector functions (182-184).”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [182]
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The liver as a central "hub" of the immune system: pathophysiological implications
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- Authors
- Guidotti, L. G., Rochford, R., Chung, J., Shapiro, M., Purcell, R., & Chisari, F. V.
- Affiliations
- Scripps Research Institute (US)
- University of Michigan (US)
- Bioqual (US)
- National Institutes of Health (US)
- Corresponding author
- Chisari, Francis V.
- Venue
- Science
- Published
- 1999-04-30
- Volume
- 284
- Issue
- 5415
- Pages
- 825-829
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2157098396
- Cited by
- 1,223
- References
- 0
- Citations by year
- 2026: 16 · 2025: 14 · 2024: 19 · 2023: 20 · 2022: 25 · 2021: 45 · 2020: 38 · 2019: 42 · 2018: 41 · 2017: 42 · 2016: 40 · 2015: 59 · 2014: 66 · 2013: 42 · 2012: 55
- FWCI
- 53.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- National Cancer Institute (R37CA040489)
- National Institute of Allergy and Infectious Diseases (R01AI020001, R01AI040696)
- Topics
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- hepatitis B virus, acute hepatitis B, viral clearance, chimpanzees, CD8+ T cells, hepatocyte destruction, HBV DNA, covalently closed circular DNA, viral replication intermediates, T cell infiltration
- MeSH terms
- Acute Disease, Animals, Pan troglodytes, Cytotoxicity, Immunologic, DNA, Circular, DNA, Viral, Hepatitis B, Hepatitis B Antibodies, Hepatitis B Core Antigens, Hepatitis B virus, Killer Cells, Natural, Liver, Mice, Transgenic, T-Lymphocytes, Time Factors, Virus Replication, Mice
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