The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Action of DNA Repair Endonuclease ERCC1/XPF in Living Cells
Abstract
To study the nuclear organization and dynamics of nucleotide excision repair (NER), the endonuclease ERCC1/XPF (for excision repair cross complementation group 1/xeroderma pigmentosum group F) was tagged with green fluorescent protein and its mobility was monitored in living Chinese hamster ovary cells. In the absence of DNA damage, the complex moved freely through the nucleus, with a diffusion coefficient (15 ± 5 square micrometers per second) consistent with its molecular size. Ultraviolet light–induced DNA damage caused a transient dose-dependent immobilization of ERCC1/XPF, likely due to engagement of the complex in a single repair event. After 4 minutes, the complex regained mobility. These results suggest (i) that NER operates by assembly of individual NER factors at sites of DNA damage rather than by preassembly of holocomplexes and (ii) that ERCC1/XPF participates in repair of DNA damage in a distributive fashion rather than by processive scanning of large genome segments.
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Cites
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Cited by
Genome maintenance mechanisms for preventing cancer
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The nucleolus as a multiphase liquid condensate
Lafontaine, D. L. J., Riback, J. A., Bascetin, R., & Brangwynne, C. P. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0272-6 · Cited by 1,051
Checking on DNA damage in S phase
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Protein Dynamics: Implications for Nuclear Architecture and Gene Expression
Misteli, T. (2001) · Science · doi:10.1126/science.291.5505.843 · Cited by 668
Metadata
- Authors
- Houtsmuller, A. B., Rademakers, S., Nigg, A. L., Hoogstraten, D., J., J. H., Hoeijmakers, & Vermeulen, W.
- Venue
- Science
- Published
- 1999-05-07
- Volume
- 284
- Issue
- 5416
- Pages
- 958-961
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2063260609
- Cited by
- 351
- References
- 38
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Houtsmuller, A. B., Rademakers, S., Nigg, A. L., Hoogstraten, D., J., J. H., Hoeijmakers, & Vermeulen, W. (1999). Action of DNA Repair Endonuclease ERCC1/XPF in Living Cells. Science. https://doi.org/10.1126/science.284.5416.958
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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