The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Spatiotemporal Dynamics of Inositol 1,4,5-Trisphosphate That Underlies Complex Ca 2+ Mobilization Patterns
Abstract
Inositol 1,4,5-trisphosphate (IP 3 ) is a second messenger that elicits complex spatiotemporal patterns of calcium ion (Ca 2+ ) mobilization and has essential roles in the regulation of many cellular functions. In Madin-Darby canine kidney epithelial cells, green fluorescent protein–tagged pleckstrin homology domain translocated from the plasma membrane to the cytoplasm in response to increased concentration of IP 3 . The detection of translocation enabled monitoring of IP 3 concentration changes within single cells and revealed spatiotemporal dynamics in the concentration of IP 3 synchronous with Ca 2+ oscillations and intracellular and intercellular IP 3 waves that accompanied Ca 2+ waves. Such changes in IP 3 concentration may be fundamental to Ca 2+ signaling.
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Cites
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain
Lemmon, M. A., Ferguson, K. M., O'Brien, R., Sigler, P. B., & Schlessinger, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10472 · Cited by 566
Cited by
Membrane recognition by phospholipid-binding domains
Lemmon, M. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2328 · Cited by 1,419
Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells
Gillooly, D. J., Morrow, I. C., Lindsay, M., Gould, R., Bryant, N. J., Gaullier, J., Parton, R. G., & Stenmark, H. (2000) · The EMBO Journal · doi:10.1093/emboj/19.17.4577 · Cited by 1,031
PIP2and Proteins: Interactions, Organization, and Information Flow
McLaughlin, S., Wang, J., Gambhir, A., & Murray, D. (2002) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.31.082901.134259 · Cited by 837
PIP 2 Is a Necessary Cofactor for Ion Channel Function: How and Why?
Suh, B.-C., & Hille, B. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.032807.125859 · Cited by 646
Kadamur, G., & Ross, E. M. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183750 · Cited by 529
Metadata
- Authors
- Hirose, K., Kadowaki, S., Tanabe, M., Takeshima, H., & Iino, M.
- Venue
- Science
- Published
- 1999-05-28
- Volume
- 284
- Issue
- 5419
- Pages
- 1527-1530
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2072459093
- Cited by
- 513
- References
- 2
- FWCI
- 22.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hirose, K., Kadowaki, S., Tanabe, M., Takeshima, H., & Iino, M. (1999). Spatiotemporal Dynamics of Inositol 1,4,5-Trisphosphate That Underlies Complex Ca 2+ Mobilization Patterns. Science. https://doi.org/10.1126/science.284.5419.1527
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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