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Positive Selection of Natural Autoreactive B Cells
Abstract
Lymphocyte development is critically influenced by self-antigens. T cells are subject to both positive and negative selection, depending on their degree of self-reactivity. Although B cells are subject to negative selection, it has been difficult to test whether self-antigen plays any positive role in B cell development. A murine model system of naturally generated autoreactive B cells with a germ line gene–encoded specificity for the Thy-1 (CD90) glycoprotein was developed, in which the presence of self-antigen promotes B cell accumulation and serum autoantibody secretion. Thus, B cells can be subject to positive selection, generated, and maintained on the basis of their autoreactivity.
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Citations
Cited by
Delves, P. J., & Roitt, I. M. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007063430107 · Cited by 1,666
The double life of a B-1 cell: self-reactivity selects for protective effector functions
Baumgarth, N. (2011) · Nature Reviews Immunology · doi:10.1038/nri2901 · Cited by 969
Pillai, S., Cariappa, A., & Moran, S. T. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115728 · Cited by 466
Cancro, M. P. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-092419-031130 · Cited by 464
Population Biology of Lymphocytes: The Flight for Survival
Freitas, A. A., & Rocha, B. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.83 · Cited by 426
Metadata
- Authors
- Hayakawa, K., Asano, M., Shinton, S. A., Gui, M., Allman, D., Stewart, C. L., Silver, J., & Hardy, R. R.
- Venue
- Science
- Published
- 1999-07-02
- Volume
- 285
- Issue
- 5424
- Pages
- 113-116
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2043186109
- Cited by
- 576
- References
- 0
- FWCI
- 13.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hayakawa, K., Asano, M., Shinton, S. A., Gui, M., Allman, D., Stewart, C. L., Silver, J., & Hardy, R. R. (1999). Positive Selection of Natural Autoreactive B Cells. Science. https://doi.org/10.1126/science.285.5424.113
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
