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A Phospholipase C-Dependent Inositol Polyphosphate Kinase Pathway Required for Efficient Messenger RNA Export
Abstract
In order to identify additional factors required for nuclear export of messenger RNA, a genetic screen was conducted with a yeast mutant deficient in a factor Gle1p, which associates with the nuclear pore complex (NPC). The three genes identified encode phospholipase C and two potential inositol polyphosphate kinases. Together, these constitute a signaling pathway from phosphatidylinositol 4,5-bisphosphate to inositol hexakisphosphate (IP 6 ). The common downstream effects of mutations in each component were deficiencies in IP 6 synthesis and messenger RNA export, indicating a role for IP 6 in GLE1 function and messenger RNA export.
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Cites
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Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
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Metadata
- Authors
- York, J. D., Odom, A. R., Murphy, R., Ives, E. B., & Wente, S. R.
- Venue
- Science
- Published
- 1999-07-02
- Volume
- 285
- Issue
- 5424
- Pages
- 96-100
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966677529
- Cited by
- 546
- References
- 1
- FWCI
- 10.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- York, J. D., Odom, A. R., Murphy, R., Ives, E. B., & Wente, S. R. (1999). A Phospholipase C-Dependent Inositol Polyphosphate Kinase Pathway Required for Efficient Messenger RNA Export. Science. https://doi.org/10.1126/science.285.5424.96
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
