The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator
Abstract
The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS expression on human monocytes could be up-regulated by interferon-γ. Soluble BLyS functioned as a potent B cell growth factor in costimulation assays. Administration of soluble recombinant BLyS to mice disrupted splenic B and T cell zones and resulted in elevated serum immunoglobulin concentrations. The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation.
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Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S.-I., Nakajima, K., Koyama, K., Iwamatsu, A., et al. (1986) · Nature · doi:10.1038/324073a0 · Cited by 2,139
Cited by
The TNF and TNF Receptor Superfamilies
Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650
Moreaux, J., Legouffe, E., Jourdan, E., Quittet, P., Rème, T., Lugagne, C., Moine, P., Rossi, J.-F., Klein, B., & Tarte, K. (2004) · Blood · doi:10.1182/blood-2003-06-1984 · Cited by 558
Stohl, W., Metyas, S., Tan, S., Cheema, G. S., Oamar, B., Xu, D., Roschke, V., Wu, Y., Baker, K. P., & Hilbert, D. M. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11354 · Cited by 503
Self-citationOverexpression of the Cytokine BAFF and Autoimmunity Risk
Steri, M., Orrù, V., Idda, M. L., Pitzalis, M., Pala, M., Zara, I., Sidore, C., Faà, V., Floris, M., Deiana, M., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1610528 · Cited by 382
Jonsson, M. V., Szodoray, P., Jellestad, S., Jonsson, R., & Skarstein, K. (2005) · Journal of Clinical Immunology · doi:10.1007/s10875-005-4091-5 · Cited by 229
Metadata
- Authors
- Moore, P. A., Belvedere, O., Orr, A., Pieri, K., LaFleur, D. W., Feng, P., Soppet, D., Charters, M., Gentz, R., Parmelee, D., Li, Y., Galperina, O., Giri, J., Roschke, V., Nardelli, B., Carrell, J., Sosnovtseva, S., Greenfield, W., Ruben, S. M., Olsen, H. S., Fikes, J., & Hilbert, D. M.
- Venue
- Science
- Published
- 1999-07-09
- Volume
- 285
- Issue
- 5425
- Pages
- 260-263
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2152330468
- Cited by
- 1,144
- References
- 1
- FWCI
- 12.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Moore, P. A., Belvedere, O., Orr, A., Pieri, K., LaFleur, D. W., Feng, P., Soppet, D., Charters, M., Gentz, R., Parmelee, D., Li, Y., Galperina, O., Giri, J., Roschke, V., Nardelli, B., Carrell, J., Sosnovtseva, S., Greenfield, W., Ruben, S. M., . . . Hilbert, D. M. (1999). BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator. Science. https://doi.org/10.1126/science.285.5425.260
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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