The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Two-Metal-Ion Catalysis in Adenylyl Cyclase
Abstract
Adenylyl cyclase (AC) converts adenosine triphosphate (ATP) to cyclic adenosine monophosphate, a ubiquitous second messenger that regulates many cellular functions. Recent structural studies have revealed much about the structure and function of mammalian AC but have not fully defined its active site or catalytic mechanism. Four crystal structures were determined of the catalytic domains of AC in complex with two different ATP analogs and various divalent metal ions. These structures provide a model for the enzyme-substrate complex and conclusively demonstrate that two metal ions bind in the active site. The similarity of the active site of AC to those of DNA polymerases suggests that the enzymes catalyze phosphoryl transfer by the same two-metal-ion mechanism and likely have evolved from a common ancestor.
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Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution
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Reaction mechanism of alkaline phosphatase based on crystal structures
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Complexity and Diversity of Mammalian Adenylyl Cyclases
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Self-citationCrystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G sα ·GTPγS
Tesmer, J. J. G., Sunahara, R. K., Gilman, A. G., & Sprang, S. R. (1997) · Science · doi:10.1126/science.278.5345.1907 · Cited by 796
Self-citationSTRUCTURES OF TERNARY COMPLEXES OF RAT DNA POLYMERASE BETA, A DNA TEMPLATE-PRIMER, AND DDCTP: 2bpf
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Structures of Ternary Complexes of Rat DNA Polymerase β, a DNA Template-Primer, and ddCTP
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Chan, C., Paul, R., Samoray, D., Amiot, N. C., Giese, B., Jenal, U., & Schirmer, T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406134101 · Cited by 477
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Metadata
- Authors
- Tesmer, J. J. G., Sunahara, R. K., Johnson, R. A., Gosselin, G., Gilman, A. G., & Sprang, S. R.
- Venue
- Science
- Published
- 1999-07-30
- Volume
- 285
- Issue
- 5428
- Pages
- 756-760
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2151421295
- Cited by
- 305
- References
- 32
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tesmer, J. J. G., Sunahara, R. K., Johnson, R. A., Gosselin, G., Gilman, A. G., & Sprang, S. R. (1999). Two-Metal-Ion Catalysis in Adenylyl Cyclase. Science. https://doi.org/10.1126/science.285.5428.756
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
