The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Insights into Editing from an Ile-tRNA Synthetase Structure with tRNA Ile and Mupirocin
Abstract
Isoleucyl–transfer RNA (tRNA) synthetase (IleRS) joins Ile to tRNA Ile at its synthetic active site and hydrolyzes incorrectly acylated amino acids at its editing active site. The 2.2 angstrom resolution crystal structure of Staphylococcus aureus IleRS complexed with tRNA Ile and Mupirocin shows the acceptor strand of the tRNA Ile in the continuously stacked, A-form conformation with the 3′ terminal nucleotide in the editing active site. To position the 3′ terminus in the synthetic active site, the acceptor strand must adopt the hairpinned conformation seen in tRNA Gln complexed with its synthetase. The amino acid editing activity of the IleRS may result from the incorrect products shuttling between the synthetic and editing active sites, which is reminiscent of the editing mechanism of DNA polymerases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The CCP4 suite: programs for protein crystallography
Collaborative Computational Project, N. 4. (1994) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444994003112 · Cited by 17,270
Methods used in the structure determination of bovine mitochondrial F1 ATPase
Abrahams, J. P., & Leslie, A. G. W. (1996) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444995008754 · Cited by 1,089
Beese, L. S., & Steitz, T. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07917.x · Cited by 1,048
Self-citationStructure of E. coli Glutaminyl-tRNA Synthetase Complexed with tRNA Gln and ATP at 2.8 Å Resolution
Rould, M. A., Perona, J. J., Söll, D., & Steitz, T. A. (1989) · Science · doi:10.1126/science.2479982 · Cited by 886
Self-citationFUNCTION AND STRUCTURE RELATIONSHIPS IN DNA POLYMERASES
Joyce, C. M., & Steitz, T. A. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.004021 · Cited by 619
Self-citationThe frequency of errors in protein biosynthesis
Loftfield, R. B., & Vanderjagt, D. (1972) · Biochemical Journal · doi:10.1042/bj1281353 · Cited by 399
Cross-validated maximum likelihood enhances crystallographic simulated annealing refinement
Adams, P. D., Pannu, N. S., Read, R. J., & Brünger, A. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5018 · Cited by 343
Cocrystal structure of an editing complex of Klenow fragment with DNA.
Freemont, P. S., Friedman, J. M., Beese, L. S., Sanderson, M. R., & Steitz, T. A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.8924 · Cited by 325
Self-citationEnzyme Structure with Two Catalytic Sites for Double-Sieve Selection of Substrate
Nureki, O., Vassylyev, D. G., Tateno, M., Shimada, A., Nakama, T., Fukai, S., Konno, M., Hendrickson, T. L., Schimmel, P., & Yokoyama, S. (1998) · Science · doi:10.1126/science.280.5363.578 · Cited by 317
Baldwin, A. N., & Berg, P. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96841-9 · Cited by 299
Cited by
Zinc coordination sphere in biochemical zinc sites
Auld, D. S. (2001) · Biometals · doi:10.1023/a:1012976615056 · Cited by 721
Tools for the automatic identification and classification of RNA base pairs
Yang, H. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg529 · Cited by 286
The 2 Å crystal structure of leucyl-tRNA synthetase and its complex with a leucyl-adenylate analogue
Cusack, S., Yaremchuk, A., & Tukalo, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.10.2351 · Cited by 259
Brkic, A., Leibundgut, M., Jablonska, J., Zanki, V., Car, Z., Petrovic Perokovic, V., Marsavelski, A., Ban, N., & Gruic-Sovulj, I. (2023) · Nature Communications · doi:10.1038/s41467-023-41244-3 · Cited by 15
Metadata
- Authors
- Silvian, L. F., Wang, J., & Steitz, T. A.
- Venue
- Science
- Published
- 1999-08-13
- Volume
- 285
- Issue
- 5430
- Pages
- 1074-1077
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2109526373
- Cited by
- 401
- References
- 21
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Insights into Editing from an Ile-tRNA Synthetase Structure with tRNA Ile and Mupirocin. https://app.cochat.ai/papers/10.1126/science.285.5430.1074
- The paper
- Silvian, L. F., Wang, J., & Steitz, T. A. (1999). Insights into Editing from an Ile-tRNA Synthetase Structure with tRNA Ile and Mupirocin. Science. https://doi.org/10.1126/science.285.5430.1074
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
