The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Genetic Variation in Susceptibility to Endocrine Disruption by Estrogen in Mice
Abstract
Large (more than 16-fold) differences in susceptibility to disruption of juvenile male reproductive development by 17β-estradiol (E 2 ) were detected between strains of mice. Effects of strain, E 2 dose, and the interaction of strain and E 2 dose on testes weight and spermatogenesis were all highly significant ( P < 0.0001). Spermatid maturation was eliminated by low doses of E 2 in strains such as C57BL/6J and C17/Jls. In contrast, mice of the widely used CD-1 line, which has been selected for large litter size, showed little or no inhibition of spermatid maturation even in response to 16 times as much E 2 . Product safety bioassays conducted with animals selected for fecundity may greatly underestimate disruption of male reproductive development by estradiol and environmental estrogenic compounds.
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Jobling, S., Reynolds, T., White, R., Parker, M. G., & Sumpter, J. P. (1995) · Environmental Health Perspectives · doi:10.1289/ehp.95103582 · Cited by 1,259
An updated review of environmental estrogen and androgen mimics and antagonists
Sonnenschein, C., & Soto, A. M. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00027-2 · Cited by 990
Vom Saal, F. S., Cooke, P. S., Buchanan, D. L., Palanza, P., Thayer, K. A., Nagel, S. C., Parmigiani, S., & Welshons, W. V. (1998) · Toxicology and Industrial Health · doi:10.1177/074823379801400115 · Cited by 757
Hypospadias Trends in Two US Surveillance Systems
Paulozzi, L. J., Erickson, J. D., & Jackson, R. J. (1997) · Pediatrics · doi:10.1542/peds.100.5.831 · Cited by 555
Development of a microtitre plate enzyme immunoassay for the determination of progesterone
Munro, C., & Stabenfeldt, G. (1984) · Journal of Endocrinology · doi:10.1677/joe.0.1010041 · Cited by 452
Contraceptive efficacy of testosterone-induced azoospermia in normal men
(1990) · The Lancet · doi:10.1016/0140-6736(90)92416-f · Cited by 428
Behre, H. M., Baus, S., Kliesch, S., Keck, C., Simoni, M., & Nieschlag, E. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.8.7543113 · Cited by 132
Genetic studies of ovulation rate in the mouse
Land, R. B., & Falconer, D. S. (1969) · Genetics Research · doi:10.1017/s0016672300002718 · Cited by 93
GENETIC CONTROL OF OVULATION RATE AND EMBRYO SURVIVAL IN MICE. I. RESPONSE TO SELECTION
Bradford, G. E. (1969) · Genetics · doi:10.1093/genetics/61.4.905 · Cited by 81
Medical Hypothesis: Bifunctional Genetic-Hormonal Pathways to Breast Cancer
Davis, D. L., TELANG, N. T., Osborne, M. P., & Bradlow, H. L. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s3571 · Cited by 53
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Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
Skakkebæk, N. E., Rajpert-De Meyts, E., & Main, K. M. (2001) · Human Reproduction · doi:10.1093/humrep/16.5.972 · Cited by 2,260
O’Donnell, L., Robertson, K. M., Jones, M. E., & Simpson, E. R. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.3.0431 · Cited by 757
Akingbemi, B. T., Sottas, C. M., Koulova, A. I., Klinefelter, G. R., & Hardy, M. P. (2004) · Endocrinology · doi:10.1210/en.2003-1174 · Cited by 516
A review of the carcinogenic potential of bisphenol A
Seachrist, D. D., Bonk, K. W., Ho, S.-M., Prins, G. S., Soto, A. M., & Keri, R. A. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2015.09.006 · Cited by 490
Metadata
- Authors
- Spearow, J. L., Doemeny, P., Sera, R., Leffler, R., & Barkley, M.
- Venue
- Science
- Published
- 1999-08-20
- Volume
- 285
- Issue
- 5431
- Pages
- 1259-1261
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2054932840
- Cited by
- 254
- References
- 13
- FWCI
- 20.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Spearow, J. L., Doemeny, P., Sera, R., Leffler, R., & Barkley, M. (1999). Genetic Variation in Susceptibility to Endocrine Disruption by Estrogen in Mice. Science. https://doi.org/10.1126/science.285.5431.1259
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.