The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dual Function of the Selenoprotein PHGPx During Sperm Maturation
Abstract
The selenoprotein phospholipid hydroperoxide glutathione peroxidase (PHGPx) changes its physical characteristics and biological functions during sperm maturation. PHGPx exists as a soluble peroxidase in spermatids but persists in mature spermatozoa as an enzymatically inactive, oxidatively cross-linked, insoluble protein. In the midpiece of mature spermatozoa, PHGPx protein represents at least 50 percent of the capsule material that embeds the helix of mitochondria. The role of PHGPx as a structural protein may explain the mechanical instability of the mitochondrial midpiece that is observed in selenium deficiency.
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Cites
Stadtman, T. C. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.000551 · Cited by 364
Cited by
Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084
The importance of selenium to human health
Rayman, M. P. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02490-9 · Cited by 4,163
Rayman, M. P. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61452-9 · Cited by 3,563
Lipid peroxidation and ferroptosis: The role of GSH and GPx4
Ursini, F., & Maiorino, M. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.027 · Cited by 1,954
Self-citationBrigelius-Flohé, R., & Maiorino, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.11.020 · Cited by 1,904
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Metadata
- Authors
- Ursini, F., Heim, S., Kiess, M., Maiorino, M., Roveri, A., Wissing, J., & Flohé, L.
- Venue
- Science
- Published
- 1999-08-27
- Volume
- 285
- Issue
- 5432
- Pages
- 1393-1396
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2017906971
- Cited by
- 903
- References
- 1
- FWCI
- 25.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ursini, F., Heim, S., Kiess, M., Maiorino, M., Roveri, A., Wissing, J., & Flohé, L. (1999). Dual Function of the Selenoprotein PHGPx During Sperm Maturation. Science. https://doi.org/10.1126/science.285.5432.1393
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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