The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Antiangiogenic Activity of the Cleaved Conformation of the Serpin Antithrombin
Abstract
Antithrombin, a member of the serpin family, functions as an inhibitor of thrombin and other enzymes. Cleavage of the carboxyl-terminal loop of antithrombin induces a conformational change in the molecule. Here it is shown that the cleaved conformation of antithrombin has potent antiangiogenic and antitumor activity in mouse models. The latent form of intact antithrombin, which is similar in conformation to the cleaved molecule, also inhibited angiogenesis and tumor growth. These data provide further evidence that the clotting and fibrinolytic pathways are directly involved in the regulation of angiogenesis.
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1 retracted
Heparin binding site, conformational change, and activation of antithrombin
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RetractedPatterns and emerging mechanisms of the angiogenic switch during tumorigenesis
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Self-citationTumors: Wounds That Do Not Heal
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Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
Boehm, T., Folkman, J., Browder, T., & O'Reilly, M. S. (1997) · Nature · doi:10.1038/37126 · Cited by 1,683
Self-citationAngiostatin induces and sustains dormancy of human primary tumors in mice
O'Reilly, M. S., Holmgren, L., Chen, C., & Folkman, J. (1996) · Nature Medicine · doi:10.1038/nm0696-689 · Cited by 1,184
Self-citationInhibition of Angiogenesis by Recombinant Human Platelet Factor-4 and Related Peptides
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Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene
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Mobile reactive centre of serpins and the control of thrombosis
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Vascular-specific growth factors and blood vessel formation
Yancopoulos, G. D., Davis, S., Gale, N. W., Rudge, J. S., Wiegand, S. J., & Holash, J. (2000) · Nature · doi:10.1038/35025215 · Cited by 3,699
Microenvironmental regulation of metastasis
Joyce, J. A., & Pollard, J. W. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2618 · Cited by 3,684
Angiogenesis: regulators and clinical applications
Liekens, S., De Clercq, E., & Neyts, J. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00529-3 · Cited by 748
The thyroxine-binding proteins
Schussler, G. C. (2000) · Thyroid · doi:10.1089/thy.2000.10.141 · Cited by 329
The Hemostatic System as a Regulator of Angiogenesis
Browder, T., Folkman, J., & Pirie-Shepherd, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.1521 · Cited by 316
Self-citation
Metadata
- Authors
- O'Reilly, M. S., Pirie-Shepherd, S., Lane, W. S., & Folkman, J.
- Venue
- Science
- Published
- 1999-09-17
- Volume
- 285
- Issue
- 5435
- Pages
- 1926-1928
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2141836567
- Cited by
- 432
- References
- 15
- FWCI
- 18.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Antiangiogenic Activity of the Cleaved Conformation of the Serpin Antithrombin. https://app.cochat.ai/papers/10.1126/science.285.5435.1926
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- O'Reilly, M. S., Pirie-Shepherd, S., Lane, W. S., & Folkman, J. (1999). Antiangiogenic Activity of the Cleaved Conformation of the Serpin Antithrombin. Science. https://doi.org/10.1126/science.285.5435.1926
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
