Angiogenesis: regulators and clinical applications

Angiogenesis in cancer, vascular, rheumatoid and other disease

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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Endostatin: an endogenous inhibitor of angiogenesis and tumor growth

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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

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Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

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Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

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Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

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Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

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Angiogenesis.

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Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.

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Antitumor Activity of Thalidomide in Refractory Multiple Myeloma

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Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor

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Thalidomide is an inhibitor of angiogenesis.

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Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

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Cyclooxygenase regulates angiogenesis induced by colon cancer cells

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Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

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Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model

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Transforming growth factor beta

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Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

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Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

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Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.

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Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis

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Regulation of matrix metalloproteinase expression in tumor invasion

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Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

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Definition of Two Angiogenic Pathways by Distinct α v Integrins

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Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

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Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis

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Structural and functional diversity in the FGF receptor multigene family.

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Angiostatin induces and sustains dormancy of human primary tumors in mice

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Activation mechanisms of matrix metalloproteinases.

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Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

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SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.

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Clinical applications of angiogenic growth factors and their inhibitors

Ferrara, N., & Alitalo, K. (1999) · Nature Medicine · doi:10.1038/70928 · Cited by 1,004 · see citing works

Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice

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Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.

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Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation.

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Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro

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Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing.

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Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin.

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Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

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New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF

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Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity

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Matrix metalloproteinases and metastasis

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Tumour suppression by the human von Hippel-Lindau gene product

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The codependence of angiogenesis and chronic inflammation

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Involvement of Interleukin-8, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor in Tumor Necrosis Factor Alpha-Dependent Angiogenesis

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Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization

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Combined effects of angiostatin and ionizing radiation in antitumour therapy

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Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors.

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Matrix metalloproteinases in tumour invasion and metastasis

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The role of αv integrins during angiogenesis: insights into potential mechanisms of action and clinical development

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Vascular endothelial growth factor is essential for corpus luteum angiogenesis

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Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature.

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Disruption of Angiogenesis by PEX, a Noncatalytic Metalloproteinase Fragment with Integrin Binding Activity

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Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2.

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Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells

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Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1

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Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

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Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells

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Tumor targeting with a selective gelatinase inhibitor

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Human Erythropoietin Induces a Pro-Angiogenic Phenotype in Cultured Endothelial Cells and Stimulates Neovascularization In Vivo

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Vascular Endothelial Growth Factor: Molecular and Biological Aspects

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V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.

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Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells

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Angiostatin binds ATP synthase on the surface of human endothelial cells

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Macrophage-Derived Metalloelastase Is Responsible for the Generation of Angiostatin in Lewis Lung Carcinoma

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Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons.

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Synergistic upregulation of metalloproteinase‐9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF‐κB

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VEGFs, receptors and angiogenesis

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Hypoxia and Vascular Endothelial Growth Factor Selectively Up-regulate Angiopoietin-2 in Bovine Microvascular Endothelial Cells

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Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10

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Tissue inhibitors of metalloproteinases

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Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways

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Regulation of growth factor activation by proteoglycans: What is the role of the low affinity receptors?

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Angiopoietin-1 induces sprouting angiogenesis in vitro

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Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice

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Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia

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Vascular Endothelial Growth Factor (VEGF) Expression in Human Coronary Atherosclerotic Lesions

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Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate

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Mechanisms for pro matrix metalloproteinase activation

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Vascular Endothelial Growth Factor Upregulates the Expression of Matrix Metalloproteinases in Vascular Smooth Muscle Cells

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Antiangiogenic Activity of the Cleaved Conformation of the Serpin Antithrombin

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Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin

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Matrix Metalloproteinase Inhibition as a Novel Anticancer Strategy: A Review with Special Focus on Batimastat and Marimastat

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Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo.

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Trendsin Molecular Medicine: Matrix metalloproteinases and their inhibitors in tumour growth and invasion

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Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression.

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