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β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
Abstract
Defensins contribute to host defense by disrupting the cytoplasmic membrane of microorganisms. This report shows that human beta-defensins are also chemotactic for immature dendritic cells and memory T cells. Human beta-defensin was selectively chemotactic for cells stably transfected to express human CCR6, a chemokine receptor preferentially expressed by immature dendritic cells and memory T cells. The beta-defensin-induced chemotaxis was sensitive to pertussis toxin and inhibited by antibodies to CCR6. The binding of iodinated LARC, the chemokine ligand for CCR6, to CCR6-transfected cells was competitively displaced by beta-defensin. Thus, beta-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6.
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“Furthermore, the isoforms of the SPAG11B gene encode defensine-like peptides which are expressed by phagocytic cells (Yang et al., 1999).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Yang et al., 1999
In the citing paper
“They are also involved in the recruitment of T- and dendritic cells to facilitate the adaptive immunity (Yang et al., 1999).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Yang et al., 1999
In the citing paper
“Therefore, the recruitment of these cells to the site of a microbial invasion provides a link between innate and adaptive immunity (Yang et al., 1999).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Yang et al., 1999
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Metadata
- Authors
- Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., & Oppenheim, J. J.
- Affiliations
- Laboratory of Molecular Immunoregulation, Division of Basic Sciences,
- National Cancer Institute (US)
- Allegheny University of Health Sciences, Pittsburgh, PA 15212, USA.
- Magainin Research Institute, 5110 Campus Drive, Plymouth Meeting, PA 19642, USA.
- Department of Dermatology, Christian Albrechts University of Kiel, Schittenhelmstrasse 7, D-24105 Kiel, Germany.
- Corresponding author
- Oppenheim, J. J.
- Venue
- Science
- Published
- 1999-10-15
- Volume
- 286
- Issue
- 5439
- Pages
- 525-528
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2104159258
- Cited by
- 1,809
- References
- 27
- Citations by year
- 2026: 32 · 2025: 26 · 2024: 39 · 2023: 37 · 2022: 40 · 2021: 39 · 2020: 58 · 2019: 31 · 2018: 45 · 2017: 61 · 2016: 60 · 2015: 74 · 2014: 60 · 2013: 86 · 2012: 90
- FWCI
- 26.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01co056000-057)
- National Cancer Institute (N01 CO 56000)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- beta-defensins, CCR6, chemotaxis, dendritic cells, memory T cells, innate immunity, adaptive immunity, LARC, chemokine receptors, pertussis toxin
- MeSH terms
- Antibodies, Binding, Competitive, Cell Line, Chemotaxis, Chemotaxis, Leukocyte, Dendritic Cells, Humans, Immunity, Active, Immunity, Innate, Immunologic Memory, Virulence Factors, Bordetella, Proteins, Recombinant Proteins, Transfection, T-Lymphocyte Subsets, Macrophage Inflammatory Proteins, Receptors, Chemokine, Chemokines, CC, Defensins, beta-Defensins, Pertussis Toxin, Receptors, CCR6, Chemokine CCL20
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