The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
Abstract
Defensins contribute to host defense by disrupting the cytoplasmic membrane of microorganisms. This report shows that human beta-defensins are also chemotactic for immature dendritic cells and memory T cells. Human beta-defensin was selectively chemotactic for cells stably transfected to express human CCR6, a chemokine receptor preferentially expressed by immature dendritic cells and memory T cells. The beta-defensin-induced chemotaxis was sensitive to pertussis toxin and inhibited by antibodies to CCR6. The binding of iodinated LARC, the chemokine ligand for CCR6, to CCR6-transfected cells was competitively displaced by beta-defensin. Thus, beta-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6.
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In the citing paper
“Furthermore, the isoforms of the SPAG11B gene encode defensine-like peptides which are expressed by phagocytic cells (Yang et al., 1999).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Yang et al., 1999
In the citing paper
“They are also involved in the recruitment of T- and dendritic cells to facilitate the adaptive immunity (Yang et al., 1999).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Yang et al., 1999
In the citing paper
“Therefore, the recruitment of these cells to the site of a microbial invasion provides a link between innate and adaptive immunity (Yang et al., 1999).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Yang et al., 1999
Citations
Cites
Dendritic cells and the control of immunity
Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,496
Rollins, B. J. (1997) · Blood · doi:10.1182/blood.v90.3.909.909_909_928 · Cited by 2,126
Dieu‐Nosjean, M., Vanbervliet, B., Vicari, A. P., Bridon, J., Oldham, E., Aït‐Yahia, S., Brière, F., Zlotnik, A., Lebecque, S., & Caux, C. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.373 · Cited by 1,424
A peptide antibiotic from human skin
Harder, J., Bartels, J., Christophers, E., & Schröder, J. ‐. (1997) · Nature · doi:10.1038/43088 · Cited by 1,365
Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis
Goldman, M. J., Anderson, G. M., Stolzenberg, E. D., Kari, U. P., ZASLOFF, M. A., & Wilson, J. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81895-4 · Cited by 1,077
Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface Fluid
Smith, J. J., Travis, S. M., Greenberg, E. P., & Welsh, M. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81099-5 · Cited by 1,039
A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration
Falk, W., Goodwin, R. H., & Leonard, E. J. (1980) · Journal of Immunological Methods · doi:10.1016/0022-1759(80)90211-2 · Cited by 942
Plant Defensins: Novel Antimicrobial Peptides as Components of the Host Defense System
Broekaert, W. F., Terras, F. R. G., Cammue, B., & Osborn, R. W. (1995) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.4.1353 · Cited by 765
Chertov, O., Michiel, D. F., Xu, L., Wang, J., Tani, K., Murphy, W. J., Longo, D. L., Taub, D. D., & Oppenheim, J. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.6.2935 · Cited by 548
Self-citationhBD‐1: a novel β‐defensin from human plasma
Bensch, K. W., Raida, M., Mägert, H., Schulz‐Knappe, P., & Forssmann, W. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00687-5 · Cited by 544
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Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
Points of control in inflammation
Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168
Development, cytokine profile and function of human interleukin 17-producing helper T cells
Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828
Metadata
- Authors
- Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., & Oppenheim, J. J.
- Affiliations
- Laboratory of Molecular Immunoregulation, Division of Basic Sciences,
- National Cancer Institute (US)
- Allegheny University of Health Sciences, Pittsburgh, PA 15212, USA.
- Magainin Research Institute, 5110 Campus Drive, Plymouth Meeting, PA 19642, USA.
- Department of Dermatology, Christian Albrechts University of Kiel, Schittenhelmstrasse 7, D-24105 Kiel, Germany.
- Corresponding author
- Oppenheim, J. J.
- Venue
- Science
- Published
- 1999-10-15
- Volume
- 286
- Issue
- 5439
- Pages
- 525-528
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2104159258
- Cited by
- 1,809
- References
- 27
- Citations by year
- 2026: 32 · 2025: 26 · 2024: 39 · 2023: 37 · 2022: 40 · 2021: 39 · 2020: 58 · 2019: 31 · 2018: 45 · 2017: 61 · 2016: 60 · 2015: 74 · 2014: 60 · 2013: 86 · 2012: 90
- FWCI
- 26.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01co056000-057)
- National Cancer Institute (N01 CO 56000)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- beta-defensins, CCR6, chemotaxis, dendritic cells, memory T cells, innate immunity, adaptive immunity, LARC, chemokine receptors, pertussis toxin
- MeSH terms
- Antibodies, Binding, Competitive, Cell Line, Chemotaxis, Chemotaxis, Leukocyte, Dendritic Cells, Humans, Immunity, Active, Immunity, Innate, Immunologic Memory, Virulence Factors, Bordetella, Proteins, Recombinant Proteins, Transfection, T-Lymphocyte Subsets, Macrophage Inflammatory Proteins, Receptors, Chemokine, Chemokines, CC, Defensins, beta-Defensins, Pertussis Toxin, Receptors, CCR6, Chemokine CCL20
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