Cited by 1,809Chemokine receptors and signalingAntimicrobial Peptides and ActivitiesImmune Response and Inflammation

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β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., Oppenheim, J. J.·1999·Science

DOI 10.1126/science.286.5439.525

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Abstract

Defensins contribute to host defense by disrupting the cytoplasmic membrane of microorganisms. This report shows that human beta-defensins are also chemotactic for immature dendritic cells and memory T cells. Human beta-defensin was selectively chemotactic for cells stably transfected to express human CCR6, a chemokine receptor preferentially expressed by immature dendritic cells and memory T cells. The beta-defensin-induced chemotaxis was sensitive to pertussis toxin and inhibited by antibodies to CCR6. The binding of iodinated LARC, the chemokine ligand for CCR6, to CCR6-transfected cells was competitively displaced by beta-defensin. Thus, beta-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6.

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Authors: Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., & Oppenheim, J. J.
Affiliations: Laboratory of Molecular Immunoregulation, Division of Basic Sciences,
National Cancer Institute (US)
Allegheny University of Health Sciences, Pittsburgh, PA 15212, USA.
Magainin Research Institute, 5110 Campus Drive, Plymouth Meeting, PA 19642, USA.
Department of Dermatology, Christian Albrechts University of Kiel, Schittenhelmstrasse 7, D-24105 Kiel, Germany.
Corresponding author: Oppenheim, J. J.
ORCID: Yang, D.
Chertov, O.
Chen, Q.
Anderson, M.
Wang, J. M.
Howard, O. M. Z.
Oppenheim, J. J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1999-10-15
Volume: 286
Issue: 5439
Pages: 525-528
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.286.5439.525
OpenAlex: W2104159258
Cited by: 1,809
References: 27
Citations by year: 2026: 32 · 2025: 26 · 2024: 39 · 2023: 37 · 2022: 40 · 2021: 39 · 2020: 58 · 2019: 31 · 2018: 45 · 2017: 61 · 2016: 60 · 2015: 74 · 2014: 60 · 2013: 86 · 2012: 90
FWCI: 26.29
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (n01co056000-057)
National Cancer Institute (N01 CO 56000)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: beta-defensins, CCR6, chemotaxis, dendritic cells, memory T cells, innate immunity, adaptive immunity, LARC, chemokine receptors, pertussis toxin
MeSH terms: Antibodies, Binding, Competitive, Cell Line, Chemotaxis, Chemotaxis, Leukocyte, Dendritic Cells, Humans, Immunity, Active, Immunity, Innate, Immunologic Memory, Virulence Factors, Bordetella, Proteins, Recombinant Proteins, Transfection, T-Lymphocyte Subsets, Macrophage Inflammatory Proteins, Receptors, Chemokine, Chemokines, CC, Defensins, beta-Defensins, Pertussis Toxin, Receptors, CCR6, Chemokine CCL20

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β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

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