Cited by 936T-cell and B-cell ImmunologyMonoclonal and Polyclonal Antibodies ResearchArtificial Immune Systems Applications

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

A Direct Estimate of the Human αβ T Cell Receptor Diversity

Arstila, T. Petteri, Casrouge, Armanda, Baron, Véronique, Even, Jos, Kanellopoulos, Jean, Kourilsky, Philippe·1999·Science

DOI 10.1126/science.286.5441.958

Open this paper in CoChat — free account

Abstract

Generation and maintenance of an effective repertoire of T cell antigen receptors are essential to the immune system, yet the number of distinct T cell receptors (TCRs) expressed by the estimated 10 12 T cells in the human body is not known. In this study, TCR gene amplification and sequencing showed that there are about 10 6 different β chains in the blood, each pairing, on the average, with at least 25 different α chains. In the memory subset, the diversity decreased to 1 × 10 5 to 2 × 10 5 different β chains, each pairing with only a single α chain. Thus, the naı̈ve repertoire is highly diverse, whereas the memory compartment, here one-third of the T cell population, contributes less than 1 percent of the total diversity.

Integrity signals

Registry

Crossref · 10.1126/science.286.5441.958

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Phenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544
T-cell antigen receptor genes and T-cell recognition
Davis, M. M., & Bjorkman, P. J. (1988) · Nature · doi:10.1038/334395a0 · Cited by 3,202
Changes in thymic function with age and during the treatment of HIV infection
Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature · doi:10.1038/25374 · Cited by 1,893
LIGAND RECOGNITION BY αβ T CELL RECEPTORS
Davis, M. M., Boniface, J. J., Reich, Z., Lyons, D. S., Hampl, J., Arden, B., & Chien, Y. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.523 · Cited by 924
Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells
Tanchot, C., Lemonnier, F. A., Pérarnau, B., Freitas, A. A., & Rocha, B. (1997) · Science · doi:10.1126/science.276.5321.2057 · Cited by 856
Negative selection of lymphocytes
Nossal, G. J. V. (1994) · Cell · doi:10.1016/0092-8674(94)90331-x · Cited by 794
Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection
Butz, E. A., & Bevan, M. J. (1998) · Immunity · doi:10.1016/s1074-7613(00)80469-0 · Cited by 763
The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.
Pannetier, C., Cochet, M., Darche, S., Casrouge, A., Zöller, M., & Kourilsky, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4319 · Cited by 635
Self-citation
Expression of Two T Cell Receptor α Chains: Dual Receptor T Cells
Padovan, E., Casorati, G., Dellabona, P., Meyer, S., Brockhaus, M., & Lanzavecchia, A. (1993) · Science · doi:10.1126/science.8211163 · Cited by 550
T-cell repertoire diversity and clonal expansions in normal and clinical samples
Pannetier, C., Even, J., & Kourilsky, P. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80117-0 · Cited by 544
Self-citation

Flagged first, then by citations

Show all 30 references

Research works printed but not linked: 2

Arden B., Clark S. P., Kabelitz D., Mak T. W., Immunogenetics 42, 501 (1995);
Bacterial colonies were lifted on nylon filters (Hybond) lysed denatured fixed and then hybridized overnight at 63°C in 6× concentrated standard saline citrate 1 mM EDTA 0.5% SDS 0.1% bovine serum albumin preboiled salmon sperm DNA (100 μg/ml) with 10 pmol [γ- 32 P]-adenosine-5′-triphosphate–labeled oligonucleotides as recommended by Amersham Pharmacia Biotech and by J. Sambrook E. F. Fritsch T. Maniatis Molecular Cloning (Cold Spring Harbor Laboratory Press Cold Spring Harbor NY ed. 2 1989). The oligonucleotides were 20 to 22 mers each with melting temperature of 64°C. The first oligonucleotide mix consisted of 12 oligonucleotides and in control experiments hybridized to 87% of a mix of bacterial clones known to bear a relevant insert. We also tested two relevant clones separately and in both cases the mix hybridized to >90% of colonies although the strength of the signal was not uniform. Of 28 different clones with unrelated CDR3 sequences none gave a positive signal. The second mix consisted of five oligonucleotides. In random sequencing 19% of the clones in the first sample bore relevant inserts; the second oligonucleotide mix gave a detectable signal in 10% of the clones. We identified one relevant clone not detected by the mix and none of 16 irrelevant clones were positive.

Sorted by citations

Items 401–500 of 936

Analysis of the TCR α-chain rearrangement profile in human T lymphocytes
Fuschiotti, P., Pasqual, N., Hierle, V., Borel, E., London, J., Marche, P. N., & Jouvin‐Marche, E. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.02.017 · Cited by 27
Cross‐reactivity in T‐cell antigen recognition
Regner, M. (2001) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2001.00994.x · Cited by 27
The smallest unit: effector and memory CD8+ T cell differentiation on the single cell level
Buchholz, V. R., Gräf, P., & Busch, D. H. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00031 · Cited by 27
Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase
Cole, D. K., van den Berg, H. A., Lloyd, A., Crowther, M. D., Beck, K., Makinde, J., Miles, J. J., Bulek, A. M., Dolton, G. M., Schauenburg, A. J. A., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.741603 · Cited by 27
Intravital imaging of CD8+ T cell function in cancer
Mempel, T. R., & Bauer, C. A. (2008) · Clinical & Experimental Metastasis · doi:10.1007/s10585-008-9196-9 · Cited by 27
Not‐so‐great expectations: re‐assessing the essence of T‐cell memory
Intlekofer, A. M., Wherry, E. J., & Reiner, S. L. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00396.x · Cited by 27
A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs
English, K., Kwan, R. Y. Q., Holz, L. E., McGuffog, C., Krol, J. M. M., Kempe, D., Kaisho, T., Heath, W. R., Lisowski, L., Biro, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45612-5 · Cited by 27
Pathophysiology and preclinical relevance of experimental graft-versus-host disease in humanized mice
Ehx, G., Ritacco, C., & Baron, F. (2024) · Biomarker Research · doi:10.1186/s40364-024-00684-9 · Cited by 26
The Dynamics of T-Cell Receptor Repertoire Diversity Following Thymus Transplantation for DiGeorge Anomaly
Ciupe, S. M., Devlin, B. H., Markert, M. L., & Kepler, T. B. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000396 · Cited by 26
Balancing sensitivity and specificity in distinguishing TCR groups by CDR sequence similarity
Thakkar, N., & Bailey‐Kellogg, C. (2019) · BMC Bioinformatics · doi:10.1186/s12859-019-2864-8 · Cited by 26
High-Throughput Sequencing of Islet-Infiltrating Memory CD4+ T Cells Reveals a Similar Pattern of TCR Vβ Usage in Prediabetic and Diabetic NOD Mice
Marrero, I., Hamm, D. E., & Davies, J. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076546 · Cited by 27
Association of CD8+ T lymphocyte repertoire spreading with the severity of DRESS syndrome
Niu, J., Jia, Q., Ni, Q., Yang, Y., Chen, G., Yang, X., Zhai, Z., Yu, H., Guan, P. F., Lin, R., et al. (2015) · Scientific Reports · doi:10.1038/srep09913 · Cited by 26
Relevance of laboratory testing for the diagnosis of primary immunodeficiencies: a review of case-based examples of selected immunodeficiencies
Abraham, R. S. (2011) · Clinical and Molecular Allergy · doi:10.1186/1476-7961-9-6 · Cited by 28
Identification of human viral protein‐derived ligands recognized by individual MHCI‐restricted T‐cell receptors
Szomolay, B., Liu, J., Brown, P. E., Miles, J. J., Clement, M., Llewellyn‐Lacey, S., Dolton, G. M., Makinde, J., Lissina, A., Schauenburg, A. J. A., et al. (2016) · Immunology and Cell Biology · doi:10.1038/icb.2016.12 · Cited by 26
The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor
Marrack, P., Krovi, S. H., Silberman, D., White, J., Kushnir, E., Nakayama, M., Crooks, J. E., Danhorn, T., Leach, S. M., Anselment, R., et al. (2017) · eLife · doi:10.7554/elife.30918 · Cited by 23
T cells, cytokines, and autoantigens in multiple sclerosis
Gran, B., & Rostami, A. M. (2001) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-001-0029-3 · Cited by 26
Large-scale statistical mapping of T-cell receptor β sequences to human leukocyte antigens
Zahid, H. J., Taniguchi, R. T., Ebert, P., Chow, I., Gooley, C. J., Lv, J., Pisani, L., Rusnak, M., Elyanow, R., Takamatsu, H., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1603730 · Cited by 23
In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility
Holland, C. J., MacLachlan, B. J., Bianchi, V., Hesketh, S. J., Morgan, R., Vickery, O. N., Bulek, A. M., Fuller, A., Godkin, A. J., Sewell, A. K., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00674 · Cited by 25
powerTCR: A model-based approach to comparative analysis of the clone size distribution of the T cell receptor repertoire
Koch, H., Starenki, D., Cooper, S., Myers, R., & Li, Q.-H. (2018) · bioRxiv · doi:10.1371/journal.pcbi.1006571 · Cited by 24
Profiling the baseline performance and limits of machine learning models for adaptive immune receptor repertoire classification
Kanduri, C., Pavlović, M., Scheffer, L., Motwani, K., Chernigovskaya, M., Greiff, V., & Sandve, G. K. (2022) · GigaScience · doi:10.1093/gigascience/giac046 · Cited by 25
Functional and biophysical characterization of an HLA‐A*6801‐restricted HIV‐specific T cell receptor
Emma Gostick, D., Cole, D. K., Hutchinson, S., Wooldridge, L., Tafuro, S., Laugel, B., Lissina, A., Oxenius, A., Boulter, J. M., Price, D. A., et al. (2007) · European Journal of Immunology · doi:10.1002/eji.200636243 · Cited by 25
Recurrent aphthous ulcers—a Toll‐like receptor–mediated disease?
Hietanen, J. H. P., Häyrinen‐Immonen, R., Al‐Samadi, A., Trokovic, N., Koskenpato, K., & Konttinen, Y. T. (2011) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2011.01064.x · Cited by 25
Graft-Versus-Host Disease: A Surge of Developments
Riddell, S. R., & Appelbaum, F. R. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040198 · Cited by 25
Monitoring the T-Cell Receptor Repertoire at Single-Clone Resolution
Bonarius, H. P. J., Baas, F., Remmerswaal, E. B. M., van Lier, R. A. W., ten Berge, I. J. M., Tak, P. P., & de Vries, N. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000055 · Cited by 24
Analysis of T-Cell Receptor Repertoire in Transplantation: Fingerprint of T Cell-mediated Alloresponse
Tian, G., Li, M., & Lv, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.778559 · Cited by 24
Comparison of CDR3 length among thymocyte subpopulations: Impacts of MHC and BV segment on the CDR3 shortening
Matsutani, T., Ohmori, T., Ogata, M., Soga, H., Kasahara, S., Yoshioka, T., Suzuki, R., & Itoh, T. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.10.026 · Cited by 24
DNA demethylating agent decitabine broadens the peripheral T cell receptor repertoire
Nie, J., Zhang, Y., Li, X., Chen, M., Liu, C., & Han, W. (2016) · Oncotarget · doi:10.18632/oncotarget.9352 · Cited by 24
Establishment and Maintenance of the Human Naïve CD4+ T-Cell Compartment
Silva, S. L., & Sousa, A. E. (2016) · Frontiers in Pediatrics · doi:10.3389/fped.2016.00119 · Cited by 26
Ushering in Integrated T Cell Repertoire Profiling in Cancer
Jiang, N. J., Schonnesen, A. A., & Ma, K.-Y. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.11.005 · Cited by 25
Primer sets for cloning the human repertoire of T cell Receptor Variable regions
Boria, I., Cotella, D., Dianzani, I., Santoro, C., & Sblattero, D. (2008) · BMC Immunology · doi:10.1186/1471-2172-9-50 · Cited by 24
Do thymically and strictly extrathymically developing T cells generate similar immune responses?
Blais, M., Gérard, G., Martinic, M. M. A., Roy-Proulx, G., Zinkernagel, R. M., & Perreault, C. (2003) · Blood · doi:10.1182/blood-2003-09-3311 · Cited by 24
Simplicity belies a complex system: a response to the minimal model of immunity of Langman and Cohn
Efroni, S., & Cohen, I. R. (2002) · Cellular Immunology · doi:10.1016/s0008-8749(02)00504-x · Cited by 24
Identification of Multiple Public TCR Repertoires in Chronic Beryllium Disease
Bowerman, N. A., Falta, M. T., Mack, D. G., Wehrmann, F., Crawford, F., Mroz, M. M., Maier, L. A., Kappler, J. W., & Fontenot, A. P. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400007 · Cited by 26
Molecular mimicry in the pathogenesis of autoimmune rheumatic diseases
Fehringer, M., & Vogl, T. J. (2025) · Journal of Translational Autoimmunity · doi:10.1016/j.jtauto.2025.100269 · Cited by 26
Single-Cell TCR and Transcriptome Analysis: An Indispensable Tool for Studying T-Cell Biology and Cancer Immunotherapy
Pasetto, A., & Lu, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.689091 · Cited by 24
T-Cell Receptor Repertoire Analysis with Computational Tools—An Immunologist’s Perspective
Arunkumar, M., & Zielinski, C. E. (2021) · Cells · doi:10.3390/cells10123582 · Cited by 23
Principles in Immunology for the Design and Development of Vaccines
Meyer, C. U., & Zepp, F. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1884-4_2 · Cited by 23
The good and the bad of T cell cross-reactivity: challenges and opportunities for novel therapeutics in autoimmunity and cancer
Gouttefangeas, C., Klein, R., & Maia, A. R. R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1212546 · Cited by 25
Donor CD4 T Cell Diversity Determines Virus Reactivation in Patients After HLA-Matched Allogeneic Stem Cell Transplantation
Ritter, J. M., Seitz, V., Balzer, H., Gary, R., Lenze, D., Moi, S., Pasemann, S., Seegebarth, A., Wurdack, M., Hennig, S., et al. (2015) · American Journal of Transplantation · doi:10.1111/ajt.13241 · Cited by 23
Direct measurement of T-cell receptor repertoire diversity with AmpliCot
Baum, P. D., & McCune, J. M. (2006) · Nature Methods · doi:10.1038/nmeth949 · Cited by 23
Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity
Chen, X. T., Poncette, L., & Blankenstein, T. J. F. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161784 · Cited by 23
Autoimmunity as a Driving Force of Cognitive Evolution
Nataf, S. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00582 · Cited by 23
Examination of the highly diverse CD4 + T-cell repertoire directed against an influenza peptide: a step towards TCR proteomics
Cameron, T. O., Cohen, G. L., Islam, S. A., & Stern, L. J. (2002) · Immunogenetics · doi:10.1007/s00251-002-0508-y · Cited by 23
Stochastic competitive exclusion in the maintenance of the naïve T cell repertoire
Stirk, E. R., Lythe, G., van den Berg, H. A., & Molina-Parı́s, C. (2010) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2010.05.004 · Cited by 23
Direct measurement of lymphocyte receptor diversity
Ogle, B. M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng139 · Cited by 23
Quantitative characterization of T-cell repertoire alteration in Chinese patients with B-cell acute lymphocyte leukemia after CAR-T therapy
Wang, X., Hu, Y., Liu, X., Yu, J., Xu, P., Wei, G., Jin, C., Wu, W., Fu, H., Ding, L., et al. (2019) · Bone Marrow Transplantation · doi:10.1038/s41409-019-0625-y · Cited by 22
A comparison of clustering models for inference of T cell receptor antigen specificity
Hudson, D., Lubbock, A. L. R., Basham, M., & Koohy, H. (2024) · ImmunoInformatics · doi:10.1016/j.immuno.2024.100033 · Cited by 18
High Frequency of Herpesvirus-Specific Clonotypes in the Human T Cell Repertoire Can Remain Stable over Decades with Minimal Turnover
Neller, M. A., Burrows, J. M., Rist, M. J., Miles, J. J., & Burrows, S. R. (2012) · Journal of Virology · doi:10.1128/jvi.02180-12 · Cited by 22
Multifunctional Microwell Arrays for Single Cell Level Functional Analysis of Lymphocytes
Park, H., Kim, H., & Doh, J. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00620 · Cited by 22
Antigen-specific T cells and autoimmunity
Rojas, M., Acosta‐Ampudia, Y., Heuer, L. S., Zang, W., Monsalve, D. M., Ramı́rez-Santana, C., Anaya, J., Ridgway, W. M., Ansari, A. A., & Gershwin, M. E. (2024) · Journal of Autoimmunity · doi:10.1016/j.jaut.2024.103303 · Cited by 25
Scalable TCR synthesis and screening enable antigen reactivity mapping in vitiligo
Gaglione, S. A., Mukkamala, R. S., Krishna, C., Smith, B. E., Wadsworth, M. H., Jelinsky, S. A., Perez, C. R., Schmidt-Hong, L., Katz, E. L., Gellatly, K. J., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.01.001 · Cited by 21
Mouse Models of Heterologous Flavivirus Immunity: A Role for Cross-Reactive T Cells
Hassert, M., Brien, J. D., & Pinto, A. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01045 · Cited by 21
Allodepleted T‐cell immunotherapy after haploidentical haematopoietic stem cell transplantation without severe acute graft‐versus‐host disease ( GVHD ) in the absence of GVHD prophylaxis
Roy, D., Lachance, S., Cohen, S., Delisle, J., Kiss, T. L., Sauvageau, G., Busque, L., Ahmad, I., Bernard, L., Bambace, N. M., et al. (2019) · British Journal of Haematology · doi:10.1111/bjh.15970 · Cited by 21
Comprehensive analysis of structural and sequencing data reveals almost unconstrained chain pairing in TCRαβ complex
Shcherbinin, D. S., Belousov, V. A., & Shugay, M. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007714 · Cited by 21
Cancer systems immunology
Reticker-Flynn, N. E., & Engleman, E. G. (2020) · eLife · doi:10.7554/elife.53839 · Cited by 23
T Cell Migration Dynamics Within Lymph Nodes During Steady State: An Overview of Extracellular and Intracellular Factors Influencing the Basal Intranodal T Cell Motility
Worbs, T., & Förster, R. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-93864-4_4 · Cited by 21
Fixing an irrelevant TCRα chain reveals the importance of TCRβ diversity for optimal TCRαβ pairing and function of virus‐specific CD8+ T cells
Valkenburg, S. A., Clemens, E. B., Swan, N. G., McQuilten, H. A., Carbone, F., Doherty, P. C., Turner, S. J., & Kedzierska, K. (2010) · European Journal of Immunology · doi:10.1002/eji.201040473 · Cited by 21
αβ T-cell receptor bias in disease and therapy (Review)
WANG, C.-Y., Yu, P., He, X., FANG, Y.-X., Cheng, W., & Jing, Z. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3492 · Cited by 22
Immunological aspects of age-related diseases
Isobe, K., Nishio, N., & Hasegawa, T. (2017) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v8.i2.129 · Cited by 22
The intersection of affinity and specificity in the development and optimization of T cell receptor based therapeutics
Riley, T. P., & Baker, B. M. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.10.017 · Cited by 21
3D Analysis of the TCR/pMHCII Complex Formation in Monkeys Vaccinated with the First Peptide Inducing Sterilizing Immunity against Human Malaria
Patarroyo, M. A., Bermúdez, A., López, C., Yepes, G., & Patarroyo, M. E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009771 · Cited by 21
The Impact of Self-Tolerance on the Polyclonal CD8+ T Cell Repertoire
Kessels, H. W. H. G., de Visser, K. E., Tirion, F. H., Coccoris, M., Kruisbeek, A. M., & Schumacher, T. N. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2324 · Cited by 21
Systematic comparative study of computational methods for T-cell receptor sequencing data analysis
Afzal, S., Gil-Fariña, I., Gabriel, R., Ahmad, S., Kalle, C. V., Schmidt, M., & Fronza, R. (2017) · Briefings in Bioinformatics · doi:10.1093/bib/bbx111 · Cited by 20
Multi-tiered approach to detect autoimmune cross-reactivity of therapeutic T cell receptors
Ishii, K., Davies, J. S., Sinkoe, A. L., Nguyen, K. A., Norberg, S. M., McIntosh, C. P., Kadakia, T., Serna, C., Rae, Z., Kelly, M. C., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg9845 · Cited by 20
Circulating pre-treatment T-cell receptor repertoire as a predictive biomarker in advanced or metastatic non-small-cell lung cancer patients treated with pembrolizumab alone or in combination with chemotherapy
Abed, A., Beasley, A. B., Reid, A. L., Law, N. L., Calapre, L., Millward, M., Lo, J., & Gray, E. S. (2023) · ESMO Open · doi:10.1016/j.esmoop.2023.102066 · Cited by 20
Toward Development and Production of Human T Cells in Swine for Potential Use in Adoptive T Cell Immunotherapy
Ogle, B. M., Knudsen, B. E., Nishitai, R., Ogata, K., & Platt, J. L. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0117 · Cited by 20
The Role of CARMA1 in T Cells
Roche, M. I., Ramadas, R. A., & Medoff, B. D. (2013) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2013007056 · Cited by 21
BCR CDR3 length distributions differ between blood and spleen and between old and young patients, and TCR distributions can be used to detect myelodysplastic syndrome
Pickman, Y., Dunn‐Walters, D. K., & Mehr, R. (2013) · Physical Biology · doi:10.1088/1478-3975/10/5/056001 · Cited by 18
Wilms' tumor protein 1 (WT1) peptide vaccination in AML patients: predominant TCR CDR3β sequence associated with remission in one patient is detectable in other vaccinated patients
Ochsenreither, S., Fusi, A., Geikowski, A., Stather, D., Busse, A., Stroux, A., Letsch, A., & Keilholz, U. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1099-y · Cited by 20
IMMUNITY TO INFECTIONS AFTER HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION
Aversa, F., Prezioso, L., Manfra, I., Galaverna, F., Spolzino, A., & Monti, A. (2016) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2016.057 · Cited by 21
Autologous Stem Cell Transplantation Disrupts Adaptive Immune Responses during Rebound Simian/Human Immunodeficiency Virus Viremia
Reeves, D. B., Peterson, C. W., Kiem, H., & Schiffer, J. T. (2017) · Journal of Virology · doi:10.1128/jvi.00095-17 · Cited by 20
Exploring viral reservoir: The combining approach of cell sorting and droplet digital PCR
Gibellini, L., Pecorini, S., Biasi, S. D., Pinti, M., Bianchini, E., Gaetano, A. D., Digaetano, M., Pullano, R., Tartaro, D. L., Iannone, A., et al. (2017) · Methods · doi:10.1016/j.ymeth.2017.11.014 · Cited by 20
Diversity Generator Mechanisms Are Essential Components of Biological Systems: The Two Queen Hypothesis
Muraille, É. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00223 · Cited by 20
Characterization of Human Mucosal‐associated Invariant T (MAIT) Cells
Souter, M. N. T., Loh, L., Li, S., Meehan, B. S., Gherardin, N. A., Godfrey, D. I., Rossjohn, J., Fairlie, D. P., Kedzierska, K., Pellicci, D. G., et al. (2019) · Current Protocols in Immunology · doi:10.1002/cpim.90 · Cited by 21
The fourth dimension in immunological space: how the struggle for nutrients selects high‐affinity lymphocytes
Wensveen, F. M., van Gisbergen, K. P. J. M., & Eldering, E. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01156.x · Cited by 19
In situexpansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS
Ramadan, A. M., Lucca, L. E., Carrié, N., Desbois, S., Axisa, P., Hayder, M., Bauer, J., Liblau, R., & Mars, L. T. (2016) · Brain · doi:10.1093/brain/aww032 · Cited by 20
Recent Developments in Flow Cytometry
Scheffold, A., & Kern, F. (2000) · Journal of Clinical Immunology · doi:10.1023/a:1026454225515 · Cited by 20
Antigen presentation on MHC molecules as a diversity filter that enhances immune efficacy
van den Berg, H. A., & Rand, D. A. J. (2003) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(03)00162-0 · Cited by 20
Preconditioning with fetal cord blood facilitates engraftment of primary childhood T-cell acute lymphoblastic leukemia in immunodeficient mice
Dialynas, D. P., Lee, M.-J., Gold, D. P., Shao, L., Yu, A. L.-T., Borowitz, M. J., & Yu, J. (2001) · Blood · doi:10.1182/blood.v97.10.3218 · Cited by 20
The partitioning of TCR repertoires by thymic selection
Lo, W., & Huseby, E. S. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20230897 · Cited by 21
Better safe than sorry: Naive T-cell dynamics in healthy ageing
de Boer, R. J., Tesselaar, K., & Borghans, J. A. M. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101839 · Cited by 20
Factors governing the intranodal migration behavior of T lymphocytes
Worbs, T., Bernhardt, G., & Förster, R. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00580.x · Cited by 22
Half of the T‐cell repertoire combinatorial diversity is genetically determined in humans and humanized mice
Pham, H., Manuel, M., Petit, N. Y., Klatzmann, D., Cohen‐Kaminsky, S., Six, A., & Marodon, G. (2011) · European Journal of Immunology · doi:10.1002/eji.201141798 · Cited by 19
Rapid detection of clonal expansion of T‐cell receptor‐beta gene in patients with HBV using the real‐time PCR with DNA melting curve analysis
Yang, J., Li, M., Wang, J., Lu, H., Yao, X., He, J., & Li, L. (2010) · Hepatology Research · doi:10.1111/j.1872-034x.2009.00600.x · Cited by 19
Autoimmune susceptibility imposed by public TCRβ chains
Zhao, Y., Nguyen, P., Vogel, P., Li, B., Jones, L. L., & Geiger, T. L. (2016) · Scientific Reports · doi:10.1038/srep37543 · Cited by 19
Profiling of the TCRβ repertoire in non-model species using high-throughput sequencing
Migalska, M., Sebastián, Á., & Radwan, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-30037-0 · Cited by 19
Backbone Modifications of HLA-A2-Restricted Antigens Induce Diverse Binding and T Cell Activation Outcomes
Gibadullin, R., Randall, C. J., Sidney, J., Sette, A., & Gellman, S. H. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c00016 · Cited by 19
Mechanistic diversity in MHC class I antigen recognition
Barbosa, C. R. R., Barton, J., Shepherd, A. J., & Mishto, M. (2021) · Biochemical Journal · doi:10.1042/bcj20200910 · Cited by 18
A Mechanistic Model for Naive CD4 T Cell Homeostasis in Healthy Adults and Children
Hapuarachchi, T., Lewis, J. E. A., & Callard, R. E. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00366 · Cited by 19
Predictable αβ T-Cell Receptor Selection toward an HLA-B*3501-Restricted Human Cytomegalovirus Epitope
Brennan, R. M., Miles, J. J., Silins, S. L., Bell, M. J., Burrows, J. M., & Burrows, S. R. (2007) · Journal of Virology · doi:10.1128/jvi.00356-07 · Cited by 19
Dissection of the clonal composition of bovine αβ T cell responses using T cell receptor Vβ subfamily-specific PCR and heteroduplex analysis
Connelley, T., MacHugh, N. D., Burrells, A., & Morrison, W. I. (2008) · Journal of Immunological Methods · doi:10.1016/j.jim.2008.02.015 · Cited by 19
T-cell memory: You must remember this…
Bevan, M. J., & Goldrath, A. W. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00461-9 · Cited by 19
Unified cross-modality integration and analysis of T cell receptors and T cell transcriptomes by low-resource-aware representation learning
Gao, Y., Dong, K., Gao, Y., Jin, X., Yang, J., Yan, G. F., & Liu, Q. (2024) · Cell Genomics · doi:10.1016/j.xgen.2024.100553 · Cited by 19
B- and T-cell responses in multiple sclerosis: Novel approaches offer new insights
Hohlfeld, R., Meinl, E., & Dornmair, K. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.07.006 · Cited by 18
T cell repertoire following kidney transplantation revealed by high-throughput sequencing
Lai, L., Wang, L., Chen, H., Zhang, J., Yan, Q., Ou, M., Lin, H., Hou, X., Chen, S., Dai, Y., et al. (2016) · Transplant Immunology · doi:10.1016/j.trim.2016.08.006 · Cited by 18
Describing the diversity of Ag specific receptors in vertebrates: Contribution of repertoire deep sequencing
Castro, R., Navelsaker, S., Krasnov, A., Pasquier, L. D., & Boudinot, P. (2017) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2017.02.018 · Cited by 17
Next generation sequencing based assessment of the alloreactive T cell receptor repertoire in kidney transplant patients during rejection: a prospective cohort study
Aschauer, C., Jelencsics, K. E., Hu, K., Heinzel, A., Vetter, J., Fraunhofer, T., Schaller, S., Winkler, S., Pimenov, L., Gualdoni, G. A., et al. (2019) · BMC Nephrology · doi:10.1186/s12882-019-1541-5 · Cited by 18
Respiratory virus-induced heterologous immunity
Pusch, E., Renz, H. E., & Skevaki, C. L. (2018) · Allergo Journal International · doi:10.1007/s40629-018-0056-0 · Cited by 18
Human thymic T cell repertoire is imprinted with strong convergence to shared sequences
Heikkilä, N., Vanhanen, R., Yohannes, D. A., Kleino, I., Mattila, I. P., Saramäki, J., & Arstila, T. P. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.09.003 · Cited by 18
Self-citation
Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4+ effector memory T cells
Anderson, B. E., Tang, A. L., Wang, Y., Froicu, M., Rothstein, D. M., McNiff, J. M., Jain, D., Demetris, A. J., Färber, D. L., Shlomchik, W. D., et al. (2011) · European Journal of Immunology · doi:10.1002/eji.201141678 · Cited by 19

Authors: Arstila, T. P., Casrouge, A., Baron, V., Even, J., Kanellopoulos, J., & Kourilsky, P.
Affiliations: Inserm (FR)
Unité de Biologie Moléculaire du Gène, INSERM U277, Institut Pasteur, 75724 Paris Cedex 15, France.
Corresponding author: Arstila, T. Petteri
ORCID: Arstila, T. Petteri
Casrouge, Armanda
Kourilsky, Philippe
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1999-10-29
Volume: 286
Issue: 5441
Pages: 958-961
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.286.5441.958
OpenAlex: W2105381977
Cited by: 931
References: 30
Citations by year: 2026: 25 · 2025: 28 · 2024: 29 · 2023: 24 · 2022: 26 · 2021: 32 · 2020: 57 · 2019: 42 · 2018: 42 · 2017: 38 · 2016: 51 · 2015: 45 · 2014: 42 · 2013: 49 · 2012: 49
FWCI: 8.21
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
Physical Sciences › Computer Science › Artificial Intelligence › Artificial Immune Systems Applications
Keywords: T cell receptor diversity, alpha beta T cells, T cell receptor repertoire, T cell receptor beta chain, TCR alpha chain, T cell memory, naive T cells, T cell receptor
MeSH terms: Adult, Female, Gene Amplification, Humans, Immunologic Memory, Male, T-Lymphocytes, Genetic Variation, Gene Rearrangement, T-Lymphocyte, Receptors, Antigen, T-Cell, alpha-beta

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Direct Estimate of the Human αβ T Cell Receptor Diversity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks