Cited by 536DNA Repair MechanismsMicrotubule and mitosis dynamicsFungal and yeast genetics research

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Control of the DNA Damage Checkpoint by Chk1 and Rad53 Protein Kinases Through Distinct Mechanisms

Sanchez, Yolanda, Bachant, Jeff, Wang, Hong, Hu, Fenghua, Liu, Dou, Tetzlaff, Michael, Elledge, Stephen J.·1999·Science

Open this paper in CoChat — free account

Abstract

In response to DNA damage, cells activate checkpoint pathways that prevent cell cycle progression. In fission yeast and mammals, mitotic arrest in response to DNA damage requires inhibitory Cdk phosphorylation regulated by Chk1. This study indicates that Chk1 is required for function of the DNA damage checkpoint in Saccharomyces cerevisiae but acts through a distinct mechanism maintaining the abundance of Pds1, an anaphase inhibitor. Unlike other checkpoint mutants, chk1 mutants were only mildly sensitive to DNA damage, indicating that checkpoint functions besides cell cycle arrest influence damage sensitivity. Another kinase, Rad53, was required to both maintain active cyclin-dependent kinase 1, Cdk1(Cdc28), and prevent anaphase entry after checkpoint activation. Evidence suggests that Rad53 exerts its role in checkpoint control through regulation of the Polo kinase Cdc5. These results support a model in which Chk1 and Rad53 function in parallel through Pds1 and Cdc5, respectively, to prevent anaphase entry and mitotic exit after DNA damage. This model provides a possible explanation for the role of Cdc5 in DNA damage checkpoint adaptation.

Integrity signals

Registry

Crossref · 10.1126/science.286.5442.1166

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cell Cycle Checkpoints: Preventing an Identity Crisis
Elledge, S. J. (1996) · Science · doi:10.1126/science.274.5293.1664 · Cited by 2,050
Self-citation
Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.Preprint
Cohen‐Fix, O., Peters, J., Kirschner, M. W., & Koshland, D. E. (1996) · Genes & Development · doi:10.1101/gad.10.24.3081 · Cited by 784
The Phosphatase Cdc14 Triggers Mitotic Exit by Reversal of Cdk-Dependent Phosphorylation
Visintin, R., Craig, K. L., Hwang, E. S., Prinz, S., Tyers, M., & Amon, A. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80286-5 · Cited by 725
Single-Stranded DNA Arising at Telomeres in cdc13 Mutants May Constitute a Specific Signal for the RAD9 Checkpoint
Garvik, B. M., Carson, M., & Hartwell, L. H. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.11.6128 · Cited by 629
An ESP1/PDS1 Complex Regulates Loss of Sister Chromatid Cohesion at the Metaphase to Anaphase Transition in Yeast
Ciosk, R., Zachariae, W., Michaelis, C., Shevchenko, A., Mann, M., & Nasmyth, K. (1998) · Cell · doi:10.1016/s0092-8674(00)81211-8 · Cited by 595
Regulation of RAD53 by the ATM -Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways
Sanchez, Y., Desany, B. A., Jones, W. J., Liu, Q., Wang, B., & Elledge, S. J. (1996) · Science · doi:10.1126/science.271.5247.357 · Cited by 585
Self-citation
The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.Preprint
Allen, J. B., Zhou, Z. Y., Siede, W., Friedberg, E. C., & Elledge, S. J. (1994) · Genes & Development · doi:10.1101/gad.8.20.2401 · Cited by 497
Self-citation
The Polo‐like kinase Cdc5p and the WD‐repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae
Shirayama, M., Zachariae, W., Ciosk, R., & Nasmyth, K. (1998) · The EMBO Journal · doi:10.1093/emboj/17.5.1336 · Cited by 483
Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast.
Surana, U., Amon, A., Dowzer, C. E. A., McGrew, J. T., Byers, B., & Nasmyth, K. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05846.x · Cited by 479
Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathwayPreprint
Desany, B. A., Alcasabas, A. A., Bachant, J. B., & Elledge, S. J. (1998) · Genes & Development · doi:10.1101/gad.12.18.2956 · Cited by 448
Self-citation

Flagged first, then by citations

Show all 27 references

Research works printed but not linked: 1

Supplementary material can be found at www.sciencemag.org/feature/data/1042771.shl

Sorted by citations

Items 301–400 of 533

Sudden Telomere Lengthening Triggers a Rad53-dependent Checkpoint inSaccharomyces cerevisiae
Viscardi, V., Baroni, E., Romano, M., Lucchini, G., & Longhese, M. P. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-11-0719 · Cited by 27
Polo-like kinases in cell cycle checkpoint control
Dai, W. H. (2003) · Frontiers in bioscience · doi:10.2741/1129 · Cited by 27
Genetic evidence for a role of Saccharomyces cerevisiae Mph1 in recombinational DNA repair under replicative stress
Panico, E. R., Ede, C., Schildmann, M., Schürer, K. A., & Kramer, W. (2009) · Yeast · doi:10.1002/yea.1727 · Cited by 26
Ultraviolet irradiation-induced K+ channel activity involving p53 activation in corneal epithelial cells
Wang, L., Dai, W. H., & Lu, L. (2005) · Oncogene · doi:10.1038/sj.onc.1208547 · Cited by 26
The DNA Damage Checkpoint and Human CancerPreprint
Schultz, L. B., Chehab, N. H., Malikzay, A., DiTullio, R. A., Stavridi, E. S., & Halazonetis, T. D. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.489 · Cited by 26
DNA Damage Checkpoint
Dubitzky, W., Olaf Wolkenhauer, A., Cho, K., & Yokota, H. (2013) · Springer eBooks · doi:10.1007/978-1-4419-9863-7_100393 · Cited by 26
DDR Inc., one business, two associates
Moriel‐Carretero, M., Pasero, P., & Pardo, B. (2018) · Current Genetics · doi:10.1007/s00294-018-0908-7 · Cited by 25
Harmine-based dual inhibitors targeting histone deacetylase (HDAC) and DNA as a promising strategy for cancer therapy
Lu, D., Qu, L., Wang, C., Luo, H., Li, S., Yin, F., Liu, X., Chen, X., Luo, Z., Cui, N., et al. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.105604 · Cited by 25
Protein kinase C controls activation of the DNA integrity checkpoint
Soriano-Carot, M., Quilis, I., Bañó, M. C., & Igual, J. C. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku373 · Cited by 29
Exercising Restraints: Role of Chk1 in Regulating the Onset and Progression of Unperturbed Mitosis in Vertebrate Cells
Zachos, G., & Gillespie, D. A. (2007) · Cell Cycle · doi:10.4161/cc.6.7.4048 · Cited by 25
Precocious S-Phase Entry in Budding Yeast Prolongs Replicative State and Increases Dependence Upon Rad53 for Viability
Sidorova, J. M., & Breeden, L. L. (2002) · Genetics · doi:10.1093/genetics/160.1.123 · Cited by 25
Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1
Tsolou, A., & Lydall, D. A. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.05.010 · Cited by 25
On the Slowing of S Phase in Response to DNA Damage in Fission Yeast
Kumar, S., & Huberman, J. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407819200 · Cited by 25
Checkpoint arrest signaling in response to UV damage is independent of nucleotide excision repair in Saccharomyces cerevisiae
Zhang, H., Taylor, J., & Siede, W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300061200 · Cited by 24
Polo‐like kinase 1 may regulate G2/M transition of mouse fertilized eggs by means of inhibiting the phosphorylation of Tyr15 of Cdc2
Zhang, Z., Su, W., Feng, C., Yu, D., Cui, C., Xu, X., & Yu, B. (2007) · Molecular Reproduction and Development · doi:10.1002/mrd.20703 · Cited by 24
ATR signaling in mammalian meiosis: From upstream scaffolds to downstream signaling
Pereira, C., Smolka, M. B., Weiss, R. S., & Brieño‐Enríquez, M. A. (2020) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22401 · Cited by 26
Chl1 and Ctf4 are required for damage-induced recombinations
Ogiwara, H., Ui, A., Lai, M. S., Enomoto, T., & Seki, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.185 · Cited by 24
Nuclear pore complexes mediate subtelomeric gene silencing by regulating PCNA levels on chromatin
Choudhry, S. K., Neal, M. L., Li, S., Navare, A., van Eeuwen, T., Wozniak, R. W., Mast, F. D., Rout, M. P., & Aitchison, J. D. (2023) · The Journal of Cell Biology · doi:10.1083/jcb.202207060 · Cited by 23
A Role forSaccharomyces cerevisiaeChk1p in the Response to Replication Blocks
Schollaert, K. L., Poisson, J. M., Searle, J. S., Schwanekamp, J. A., Tomlinson, C. R., & Sánchez, Y. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-11-0792 · Cited by 23
Asf1 facilitates dephosphorylation of Rad53 after DNA double-strand break repairPreprint
Tsabar, M., Waterman, D. P., Aguilar, F., Katsnelson, L., Eapen, V. V., Memişoğlu, G., & Haber, J. E. (2016) · Genes & Development · doi:10.1101/gad.280685.116 · Cited by 26
The polo‐like kinase PLKA is required for initiation and progression through mitosis in the filamentous fungus Aspergillus nidulans
Bachewich, C., Masker, K. K., & Osmani, S. A. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04404.x · Cited by 22
Deciphering the DNA Damage Response
Haber, J. E. (2015) · Cell · doi:10.1016/j.cell.2015.08.034 · Cited by 22
Possibility of paclitaxel as an alternative radiosensitizer to 5-fluorouracil for colon cancer
Kusunoki (2010) · Oncology Reports · doi:10.3892/or.2010.1029 · Cited by 22
Double-strand breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint activation
Grenon, M., Magill, C. P., Lowndes, N. F., & Jackson, S. P. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00076.x · Cited by 22
Phosphorylation-Dependent Interactions between Crb2 and Chk1 Are Essential for DNA Damage Checkpoint
Qu, M., Yang, B., Li, T., Yates, J. R., Russell, P. R., Dong, M., & Du, L. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002817 · Cited by 21
Slx4 scaffolding in homologous recombination and checkpoint control: lessons from yeast
Cussiol, J. R. R., Dibitetto, D., Pellicioli, A., & Smolka, M. B. (2016) · Chromosoma · doi:10.1007/s00412-016-0600-y · Cited by 21
DNA-damage response in the basidiomycete fungus Ustilago maydis relies in a sole Chk1-like kinase
Pérez‐Martín, J. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.01.023 · Cited by 21
Genetic association of GWAS-supported MAD1L1 gene polymorphism rs12666575 with schizophrenia susceptibility in a Chinese population
Su, L., Shen, T., Huang, G., Long, J., Fan, J., Ling, W., & Jiang, J. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.10.061 · Cited by 20
Checkpoint genes and Exo1 regulate nearby inverted repeat fusions that form dicentric chromosomes in Saccharomyces cerevisiae
Kaochar, S., Shanks, L., & Weinert, T. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001938107 · Cited by 20
From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases
Cussiol, J. R. R., Soares, B. L., & de Oliveira, F. M. B. (2019) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2019-0071 · Cited by 21
Characterization of DNA Damage-stimulated Self-interaction ofSaccharomyces cerevisiae Checkpoint Protein Rad17p
Zhang, H., Zhu, Z., Vidanes, G. M., Mbangkollo, D., Liu, Y., & Siede, W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103682200 · Cited by 20
Activation of the S-Phase Checkpoint Inhibits Degradation of the F-Box Protein Dia2
Kile, A. C., & Koepp, D. M. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00612-09 · Cited by 19
Hsp90 induces increased genomic instability toward DNA-damaging agents by tuning down RAD53 transcription
Khurana, N., Laskar, S., Bhattacharyya, M. K., & Bhattacharyya, S. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-12-0867 · Cited by 19
Novel insights into gene expression regulation during meiosis revealed by translation elongation dynamics
Sabi, R., & Tuller, T. (2019) · npj Systems Biology and Applications · doi:10.1038/s41540-019-0089-0 · Cited by 19
Proteins in the Nutrient-Sensing and DNA Damage Checkpoint Pathways Cooperate to Restrain Mitotic Progression following DNA Damage
Searle, J. S., Wood, M. D., Kaur, M., Tobin, D. V., & Sánchez, Y. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002176 · Cited by 19
Regulation of mitosis in response to damaged or incompletely replicated DNA require different levels of Grapes (DrosophilaChk1)
Purdy, A. K., Uyetake, L., Cordeiro, M. G., & Su, T. T. (2005) · Journal of Cell Science · doi:10.1242/jcs.02454 · Cited by 19
The Protein Degradation Response of Saccharomyces cerevisiae to Classical DNA-Damaging Agents
Burgis, N. E., & Samson, L. D. (2007) · Chemical Research in Toxicology · doi:10.1021/tx700126e · Cited by 18
ATRMec1 Phosphorylation-independent Activation of Chk1 in Vivo
Chen, Y., Caldwell, J. M., Pereira, E., Baker, R. W., & Sánchez, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806530200 · Cited by 18
Cyclin Regulation by the S Phase Checkpoint
Palou, G., Palou, R., Guerra-Moreno, Á., Duch, A., Travesa, A., & Quintana, D. G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.138669 · Cited by 18
Reduced kinase activity of polo kinase Cdc5 affects chromosome stability and DNA damage response inS. cerevisiae
Rawal, C. C., Riccardo, S., Pesenti, C., Ferrari, M., Marini, F., & Pellicioli, A. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1222338 · Cited by 20
Eukaryotic Adaptation to Years-Long Starvation Resembles that of Bacteria
Aouizerat, T., Gelman, D., Szitenberg, A., Gutman, I., Coppenhagen‐Glazer, S., Reich, E., Schoemann, M., Kaplan, R., Saragovi, A., Hazan, R., et al. (2019) · iScience · doi:10.1016/j.isci.2019.08.002 · Cited by 18
DNA Damage Induces p53-dependent Down-regulation of hCHK1
Damia, G. L. M., Sánchez, Y., Erba, E., & Broggini, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007178200 · Cited by 18
Molecular signatures of diapause in the Asian longhorned beetle: Gene expression
Torson, A. S., Bowman, S., Doucet, D. S., Roe, A. D., & Sinclair, B. J. (2023) · Current Research in Insect Science · doi:10.1016/j.cris.2023.100054 · Cited by 17
Psoralen-sensitive mutant pso9-1 of Saccharomyces cerevisiae contains a mutant allele of the DNA damage checkpoint gene MEC3
Cardone, J. M., Revers, L. F., Machado, R. M., Bonatto, D., Brendel, M., & Henriques, J. A. P. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.08.018 · Cited by 17
The Relationship Between Checkpoint Adaptation and Mitotic Catastrophe in Genomic Changes in Cancer Cells
Swift, L. H., & Golsteyn, R. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803309-8.00022-7 · Cited by 19
Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis
Waskiewicz, E., Vasiliou, M., Córcoles-Sáez, I., & Rita, S. (2021) · Communications Biology · doi:10.1038/s42003-021-01884-x · Cited by 17
To Fix or Not to Fix: Maintenance of Chromosome Ends Versus Repair of DNA Double-Strand Breaks
Casari, E., Gnugnoli, M., Rinaldi, C., Pizzul, P., Colombo, C. V., Bonetti, D., & Longhese, M. P. (2022) · Cells · doi:10.3390/cells11203224 · Cited by 20
The Kinome of Edible and Medicinal Fungus Wolfiporia cocos
Wei, W., Shu, S., Zhu, W., Xiong, Y., & Peng, F. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01495 · Cited by 17
High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1
Maya‐Miles, D., Peñate, X., Olmo, T. S., Jourquin, F., Muñoz-Centeno, M. C., Mendoza, M., Simon, M., Chávez, S., & Géli, V. (2018) · eLife · doi:10.7554/elife.35337 · Cited by 19
Rad53 Kinase Activation-independent Replication Checkpoint Function of the N-terminal Forkhead-associated (FHA1) Domain
Pike, B. L., Tenis, N., & Heierhorst, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405080200 · Cited by 17
The Spindle Assembly Checkpoint Regulates the Phosphorylation State of a Subset of DNA Checkpoint Proteins in Saccharomyces cerevisiae
Clémenson, C., & Marsolier‐Kergoat, M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00310-06 · Cited by 17
Dun1, a Chk2-related kinase, is the central regulator of securin-separase dynamics during DNA damage signaling
Yam, C., Chia, D. B., Shi, I. Y., Lim, H. H., & Surana, U. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa355 · Cited by 16
High Nutrient Levels and TORC1 Activity Reduce Cell Viability following Prolonged Telomere Dysfunction and Cell Cycle Arrest
Klermund, J., Bender, K., & Luke, B. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.053 · Cited by 17
Saccharomyces cerevisiae RAD53 (CHK2) but not CHK1 is required for double-strand break-initiated SCE and DNA damage-associated SCE after exposure to X rays and chemical agents
Fasullo, M., Dong, Z., Sun, M., & Zeng, L. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.06.006 · Cited by 16
S-phase cyclins are required for a stable arrest at metaphase
Meyn, M. A., & Holloway, S. L. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00863-0 · Cited by 16
Gene expression patterns in heterozygous Plk4 murine embryonic fibroblasts
Morettin, A., Ward, A., Nantais, J., & Hudson, J. W. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-319 · Cited by 15
Rad53 Downregulates Mitotic Gene Transcription by Inhibiting the Transcriptional Activator Ndd1
Edenberg, E. R., Vashisht, A. A., Benanti, J. A., Wohlschlegel, J. A., & Toczyski, D. P. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01056-13 · Cited by 15
Impaired mitochondrial Fe-S cluster biogenesis activates the DNA damage response through different signaling mediators
Pijuan, J., María, C., Herrero, E., & Bellı́, G. (2015) · Journal of Cell Science · doi:10.1242/jcs.178046 · Cited by 15
Dissection of Rad9 BRCT domain function in the mitotic checkpoint response to telomere uncapping
Nnakwe, C. C., Altaf, M., Côté, J., & Kron, S. J. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.09.010 · Cited by 15
The checkpoint transcriptional response: Make sure to turn it off once you are satisfied
Smolka, M. B., de Oliveira, F. M. B., Harris, M. R., & de Bruin, R. A. M. (2012) · Cell Cycle · doi:10.4161/cc.21197 · Cited by 14
SUMOylation regulates pre‐mRNA splicing to overcome DNA damage in fungi
Jian, Y., Chen, X., Sun, K., Liu, Z., Cheng, D., Cao, J., Liu, J., Cheng, X., Wu, L., Zhang, F., et al. (2022) · New Phytologist · doi:10.1111/nph.18692 · Cited by 14
Surveillance mechanisms monitoring chromosome breaks during mitosis and meiosis
Longhese, M. P., Guerini, I., Baldo, V., & Clerici, M. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.09.006 · Cited by 15
The Saccharomyces cerevisiae PDS1 and RAD9 checkpoint genes control different DNA double-strand break repair pathways
DeMase, D., Zeng, L., Cera, C., & Fasullo, M. (2005) · DNA Repair · doi:10.1016/j.dnarep.2004.08.007 · Cited by 13
A Rad53 Independent Function of Rad9 Becomes Crucial for Genome Maintenance in the Absence of the RecQ Helicase Sgs1
Nielsen, I., Bentsen, I. B., Andersen, A. H., Gasser, S. M., & Bjergbæk, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081015 · Cited by 13
Tumor suppressor stars in yeast G1/S transition
Li, P., Hao, Z., & Zeng, F. (2020) · Current Genetics · doi:10.1007/s00294-020-01126-3 · Cited by 13
Function and regulation mechanism ofChk1during meiotic maturation in porcine oocytes
Nie, Z., Chen, L., Jin, Q.-S., Gao, Y., Wang, T., Zhang, X., & Miao, Y. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1373221 · Cited by 13
Quantitative Analysis of DNA Damage Signaling Responses to Chemical and Genetic Perturbations
de Oliveira, F. M. B., Kim, D.-S., Lanz, M. C., & Smolka, M. B. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7306-4_42 · Cited by 12
Genotoxic Stress Prevents Ndd1-Dependent Transcriptional Activation of G2/M-Specific Genes in Saccharomyces cerevisiae
Yelamanchi, S. K., Veis, J., Anrather, D., Klug, H., & Ammerer, G. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01090-13 · Cited by 12
Functional characterization of Candida glabrata ORF, CAGL0M02233g for its role in stress tolerance and virulence
Gupta, P., Meena, R. C., & Kumar, N. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104469 · Cited by 12
The DNA damage checkpoint and the spindle position checkpoint: guardians of meiotic commitment
Ballew, O., & Lacefield, S. (2019) · Current Genetics · doi:10.1007/s00294-019-00981-z · Cited by 12
Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies
Jiang, K., Tong, L., Wang, T., Wang, H., Hu, X., Xu, G., Jin, T., Kan, W., Xu, L., Li, J., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00652-1 · Cited by 12
Self-citation
Pds1p Is Required for Meiotic Recombination and Prophase I Progression inSaccharomyces cerevisiae
Cooper, K. F., Mallory, M. J., Guacci, V., Lowe, K., & Strich, R. (2008) · Genetics · doi:10.1534/genetics.108.095513 · Cited by 12
Prolonged cell cycle arrest in response to DNA damage in yeast requires the maintenance of DNA damage signaling and the spindle assembly checkpointPreprint
Zhou, F. Y., Waterman, D. P., Ashton, M., Caban-Penix, S., Memişoğlu, G., Eapen, V. V., & Haber, J. E. (2024) · eLife · doi:10.7554/elife.94334.3 · Cited by 12
Characterization of Pph3-mediated dephosphorylation of Rad53 during methyl methanesulfonate-induced DNA damage repair in Candida albicans
Yao, G., Wan, J., Liu, Q., Mu, C., Wang, Y., & Sang, J. (2017) · Biochemical Journal · doi:10.1042/bcj20160889 · Cited by 11
Budding yeast 14-3-3 proteins contribute to the robustness of the DNA damage and spindle checkpoints
Grandin, N., & Charbonneau, M. (2008) · Cell Cycle · doi:10.4161/cc.7.17.6592 · Cited by 11
Cdk1‐interacting protein Cip1 is regulated by the S phase checkpoint in response to genotoxic stress
Zhang, Z., Ren, P., Vashisht, A. A., Wohlschlegel, J. A., Quintana, D. G., & Zeng, F. (2017) · Genes to Cells · doi:10.1111/gtc.12518 · Cited by 11
Orchestration of the S-phase and DNA damage checkpoint pathways by replication forks from early origins
Caldwell, J. M., Chen, Y., Schollaert, K. L., Theis, J. F., Babcock, G. F., Newlon, C. S., & Sánchez, Y. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200706009 · Cited by 11
CaTip41 regulates protein phosphatase 2A activity, CaRad53 deactivation and the recovery of DNA damage-induced filamentation to yeast form inCandida albicans
Feng, J., Duan, Y., Wei, S., Qin, Y., Zhuang, Z., Zhu, D., Sun, X., & Jiang, L. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow009 · Cited by 11
DNA-damage induction of RAD54 can be regulated independently of the RAD9- and DDC1-dependent checkpoints that regulate RNR2
Walsh, L., Schmuckli‐Maurer, J., Billinton, N., Barker, G. M., Heyer, W., & Walmsley, R. M. (2002) · Current Genetics · doi:10.1007/s00294-002-0302-2 · Cited by 11
Abrogation of the Chk1-Pds1 Checkpoint Leads to Tolerance of Persistent Single-Strand Breaks in Saccharomyces cerevisiae
Karumbati, A. S., & Wilson, T. E. (2005) · Genetics · doi:10.1534/genetics.104.035931 · Cited by 11
Molecular and Cellular Biology
Stevenson, M. A., & Calderwood, S. K. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-24098-7.00002-2 · Cited by 11
Differential genetic interactions between Sgs1, DNA-damage checkpoint components and DNA repair factors in the maintenance of chromosome stability
Doerfler, L., Harris, L., Viebranz, E., & Schmidt, K. H. (2011) · Genome Integrity · doi:10.1186/2041-9414-2-8 · Cited by 10
Coordination of Chromatid Separation and Spindle Elongation by Antagonistic Activities of Mitotic and S-Phase CDKs
Liang, F., Richmond, D., & Wang, Y. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003319 · Cited by 10
DNA Damage Response Checkpoint Activation Drives KP1019 Dependent Pre-Anaphase Cell Cycle Delay in S. cerevisiae
Bierle, L. A., Reich, K. L., Taylor, B. E., Blatt, E. B., Middleton, S. M., Burke, S. D., Stultz, L. K., Hanson, P. K., Partridge, J. F., & Miller, M. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138085 · Cited by 10
Multiple Approaches to Study S. cerevisiae Rad9, a Prototypical Checkpoint Protein
O'Shaughnessy, A. M., Grenon, M., Gilbert, C., Toh, G. W. ‐., Green, C., & Lowndes, N. F. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)09008-7 · Cited by 10
Deregulated Ras signaling compromises DNA damage checkpoint recovery in S. cerevisiae
Wood, M. D., & Sánchez, Y. (2010) · Cell Cycle · doi:10.4161/cc.9.16.12713 · Cited by 10
TOWARD MAINTAINING THE GENOME
Nyberg, K. A., Michelson, R. J., Putnam, C. W., & Weinert, T. A. (2002) · Cited by 10
The Prevalence of CHEK1 and CHEK2 Mutations in Prostate Cancer: a Retrospective Cohort Study
Alorjani, M. S., Aburub, M., Al‐Trad, B., Hamad, M. A., Alarjah, M. I. A., Bashir, S. M. A., Al‐Batayneh, K., & Zoubi, M. S. A. (2023) · Medical Archives · doi:10.5455/medarh.2023.77.8-12 · Cited by 9
Cac1 WHD and PIP domains have distinct roles in replisome progression and genomic stability
Tsirkas, I., Dovrat, D., Yang, L., Kalyva, A., Lotysh, D., Li, Q., & Aharoni, A. (2020) · Current Genetics · doi:10.1007/s00294-020-01113-8 · Cited by 9
RAD53 is limiting in double-strand break repair and in protection against toxicity associated with ribonucleotide reductase inhibition
Covo, S., Westmoreland, J. W., Reddy, A. K., Gordenin, D. A., & Resnick, M. A. (2012) · DNA repair · doi:10.1016/j.dnarep.2011.12.008 · Cited by 9
Control of PCNA deubiquitylation in yeast
Gallego-Sánchez, A., Conde, F., San-Segundo, P. A., & Bueno, A. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380104 · Cited by 9
Activation of the Budding Yeast Securin Pds1 But Not Rad53 Correlates with Double-Strand Break-Associated G2/M Cell Cycle Arrest in amec1Hypomorphic Mutant
Sun, M., & Fasullo, M. (2007) · Cell Cycle · doi:10.4161/cc.6.15.4510 · Cited by 9
Molecular and Cellular Biology
Stevenson, M. A., & Calderwood, S. K. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-1637-5.00002-x · Cited by 9
PP2ACdc55 dephosphorylates Pds1 and inhibits spindle elongation in S. cerevisiae
Khondker, S., Kajjo, S., Chandler-Brown, D. B., Skotheim, J. M., Rudner, A. D., & Ikui, A. E. (2020) · Journal of Cell Science · doi:10.1242/jcs.243766 · Cited by 8
Phosphorylation-Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex
Kapoor, P., Bao, Y., Xiao, J., Espejo, A. B., Yang, L., Bedford, M. T., Peng, G., & Shen, X. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.032 · Cited by 8
The role of the DNA damage checkpoint in regulation of translesion DNA synthesis
Koren, A. (2007) · Mutagenesis · doi:10.1093/mutage/gem003 · Cited by 8
Activation of DNA Damage Checkpoints in CHO Cells Requires a Certain Level of DNA Damage
Jiang, M., Ying, Y., & Wu, J. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5655 · Cited by 8
Previously uncharacterized amino acid residues in histone H3 and H4 mutants with roles in DNA damage repair response and cellular aging
Thakre, P. K., Athira, S. V., Golla, U., Chauhan, S., & Tomar, R. S. (2018) · FEBS Journal · doi:10.1111/febs.14723 · Cited by 8
Tissue-Specific Regulation of Chk1 Expression by p53
Cheung, K.-J., & Li, G. (2001) · Experimental and Molecular Pathology · doi:10.1006/exmp.2001.2398 · Cited by 8
Checkpoint adaptation in recombination-deficient cells drives aneuploidy and resistance to genotoxic agents
Vydzhak, O., Bender, K., Klermund, J., Busch, A., Reimann, S., & Luke, B. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102939 · Cited by 7

Authors: Sanchez, Y., Bachant, J., Wang, H., Hu, F., Liu, D., Tetzlaff, M., & Elledge, S. J.
Affiliations: Howard Hughes Medical Institute,
Howard Hughes Medical Institute (US)
Corresponding author: Bachant, Jeff
Elledge, Stephen J.
ORCID: Bachant, Jeff
Hu, Fenghua
Elledge, Stephen J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1999-11-05
Volume: 286
Issue: 5442
Pages: 1166-1171
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.286.5442.1166
OpenAlex: W2091204939
Cited by: 536
References: 27
Citations by year: 2026: 5 · 2025: 5 · 2024: 14 · 2023: 7 · 2022: 13 · 2021: 7 · 2020: 11 · 2019: 18 · 2018: 12 · 2017: 12 · 2016: 18 · 2015: 15 · 2014: 12 · 2013: 26 · 2012: 15
FWCI: 12.12
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM-44664)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: DNA damage checkpoint, Chk1, Rad53, Pds1, Cdc5, Polo kinase, CDK1, Cdc28, mitotic arrest, checkpoint adaptation, Saccharomyces cerevisiae, cell cycle regulation
MeSH terms: Checkpoint Kinase 1, Anaphase, DNA Damage, DNA, Fungal, Fungal Proteins, Ligases, Mitosis, Mutation, Nuclear Proteins, Phosphorylation, Protein Kinases, Recombinant Fusion Proteins, Saccharomyces cerevisiae, S Phase, CDC2 Protein Kinase, RNA-Binding Proteins, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Cyclin B, Saccharomyces cerevisiae Proteins, Ubiquitin-Protein Ligase Complexes, Ubiquitin-Protein Ligases, Intracellular Signaling Peptides and Proteins, Anaphase-Promoting Complex-Cyclosome, Securin, Checkpoint Kinase 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Control of the DNA Damage Checkpoint by Chk1 and Rad53 Protein Kinases Through Distinct Mechanisms

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks