The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mediation by a CREB Family Transcription Factor of NGF-Dependent Survival of Sympathetic Neurons
Abstract
Nerve growth factor (NGF) and other neurotrophins support survival of neurons through processes that are incompletely understood. The transcription factor CREB is a critical mediator of NGF-dependent gene expression, but whether CREB family transcription factors regulate expression of genes that contribute to NGF-dependent survival of sympathetic neurons is unknown. CREB-mediated gene expression was both necessary for NGF-dependent survival and sufficient on its own to promote survival of sympathetic neurons. Moreover, expression of Bcl-2 was activated by NGF and other neurotrophins by a CREB-dependent transcriptional mechanism. Overexpression of Bcl-2 reduced the death-promoting effects of CREB inhibition. Together, these data support a model in which neurotrophins promote survival of neurons, in part through a mechanism involving CREB family transcription factor–dependent expression of genes encoding prosurvival factors.
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Cites
Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561
Cited by
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394
Transcriptional regulation by the phosphorylation-dependent factor CREB
Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587
Trk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537
Function and regulation of CREB family transcription factors in the nervous system
Lonze, B. E., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00828-0 · Cited by 2,127
Self-citationNeurotrophin signal transduction in the nervous system
Kaplan, D. R., & Miller, F. D. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00092-1 · Cited by 1,944
Metadata
- Authors
- Riccio, A., Ahn, S., Davenport, C. M., Blendy, J. A., & Ginty, D. D.
- Venue
- Science
- Published
- 1999-12-17
- Volume
- 286
- Issue
- 5448
- Pages
- 2358-2361
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2095435531
- Cited by
- 802
- References
- 1
- FWCI
- 17.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Riccio, A., Ahn, S., Davenport, C. M., Blendy, J. A., & Ginty, D. D. (1999). Mediation by a CREB Family Transcription Factor of NGF-Dependent Survival of Sympathetic Neurons. Science. https://doi.org/10.1126/science.286.5448.2358
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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