Reduced Numbers of Somatostatin Receptors in the Cerebral Cortex in Alzheimer's Disease
Abstract
Somatostatin receptor concentrations were measured in patients with Alzheimer's disease and controls. In the frontal cortex (Brodmann areas 6, 9, and 10) and temporal cortex (Brodmann area 21), the concentrations of somatostatin in receptors in the patients were reduced to approximately 50 percent of control values. A 40 percent reduction was seen in the hippocampus, while no significant changes were found in the cingulate cortex, postcentral gyrus, temporal pole, and superior temporal gyrus. Scatchard analysis showed a reduction in receptor number rather than a change in affinity. Somatostatin-like immunoreactivity was significantly reduced in both the frontal and temporal cortex. Somatostatin-like immunoreactivity was linearly related to somatostatin-receptor binding in the cortices of Alzheimer's patients. These findings may reflect degeneration of postsynaptic neurons or cortical afferents in the patients' cerebral cortices. Alternatively, decreased somatostatin-like immunoreactivity in Alzheimer's disease might indicate increased release of somatostatin and down regulation of postsynaptic receptors.
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Sst interneurons have been implicated in AD, but not at the same molecular, morphological and electrophysiological level, which was achieved in part by the neuronal enrichment strategy.
“Sst interneurons have been implicated in AD53,55, but not at the same molecular, morphological and electrophysiological level, which was achieved, in part, by our neuronal enrichment strategy (harnessing fluorescence-activated nuclei sorting (FANS) to enrich neuronal populations).”
From Integrated multimodal cell atlas of Alzheimer’s disease (2024) · cites this paper as [53]
Cites
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“Sst interneurons have been implicated in AD 53,55 , but not at the same molecular, morphological and electrophysiological level, which was achieved, in part, by our neuronal enrichment strategy (harnessing fluorescence-activated nuclei sorting (FANS) to enrich neuronal populations).”
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Recent advances in the modeling of Alzheimer’s disease
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- Authors
- Beal, M. F., Mazurek, M. F., Tran, V. T., Chattha, G., Bird, E. D., & Martin, J. B.
- Affiliations
- Massachusetts General Hospital (US)
- Venue
- Science
- Published
- 1985-07-19
- Volume
- 229
- Issue
- 4710
- Pages
- 289-291
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1968053343
- Cited by
- 251
- References
- 1
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2012: 2
- FWCI
- 28.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P50AG005134)
- National Institute of Neurological Disorders and Stroke (IR 23NS 19867-1, MN/NS31862)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- somatostatin receptors, Alzheimer's disease, cerebral cortex, hippocampus, receptor binding, frontal cortex, temporal cortex, neurodegeneration
- MeSH terms
- Adult, Aged, Alzheimer Disease, Cerebral Cortex, Chromatography, High Pressure Liquid, Female, Frontal Lobe, Humans, Male, Middle Aged, Neurons, Radioimmunoassay, Receptors, Cell Surface, Somatostatin, Temporal Lobe, Receptors, Somatostatin
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