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Cited by 628Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroscience and Neuropharmacology Research

A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease

Davies, C.A., Mann, D.M.A., Sumpter, P.Q., Yates, P.O.·1987·Journal of the Neurological Sciences
DOI 10.1016/0022-510x(87)90057-8
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Abstract

A quantitative morphometric analysis was used to estimate neurone and synapse densities in cerebral cortical biopsy tissues from patients with dementia under 65 years of age and pathologically verified as suffering from Alzheimer's disease. Estimates of the numerical density of neurones and synapses were made in layers II-III and V of both frontal and temporal cortex. A greater loss of synapses than that of neurones was found in Alzheimer's disease, amounting to a minimum (uncorrected for atrophy) of 25% in layers II-III and 36% in layer V of the temporal cortex, and 27% in layer V of the frontal cortex. Values of synapse to neurone ratio also demonstrated this greater loss of synapses, there being on average 38% fewer synapses associated with each surviving neurone in layers II-III of the temporal cortex, 30% fewer in layer V, and a deficit of 14% in layer V of the frontal cortex. It is concluded that a major loss of synapses occurred in this group of patients with Alzheimer's disease, probably at an early stage of the disease, and that the loss is likely to form a fundamental part of the pathological process that underlies the cortical damage of this condition.

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Crossref · 10.1016/0022-510x(87)90057-8

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  • NPTXs may be potential candidate biomarkers in AD due to their expression in neocortex and hippocampus, areas largely affected by synaptic dysfunction and loss in AD.

    “NPTXs may be potential candidate biomarkers in AD due to their expression in neocortex and hippocampus (Uhlén et al. 2015; Xu et al. 2003), areas that are largely affected by synaptic dysfunction and loss in AD (Davies et al. 1987; DeKosky and Scheff 1990; Reddy et al. 2005; Scheff et al. 2007).”

    From Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration (2022) · cites this paper as Davies et al. 1987

  • Loss of synaptic markers, specifically the pre-synaptic protein synaptophysin, is the best brain correlate of cognitive decline in AD.

    “research studies have reported that loss of synaptic markers, specifically of the pre-synaptic protein synaptophysin, is the best brain correlate of cognitive decline in AD [40, 42, 168, 184, 192].”

    From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [40]

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Authors
Davies, C. A., Mann, D. M. A., Sumpter, P. Q., & Yates, P. O.
Affiliations
University of Manchester (GB)
Corresponding author
Davies, C.A.
ORCID
Mann, D.M.A.
Venue
Journal of the Neurological Sciences
Publisher
Elsevier BV
Published
1987-04
Volume
78
Issue
2
Pages
151-164
ISSN
0022-510X (ISSN-L)
DOI
10.1016/0022-510x(87)90057-8
OpenAlex
W2020486984
Cited by
628
References
49
Citations by year
2026: 9 · 2025: 10 · 2024: 13 · 2023: 20 · 2022: 23 · 2021: 16 · 2020: 19 · 2019: 28 · 2018: 33 · 2017: 26 · 2016: 32 · 2015: 15 · 2014: 29 · 2013: 26 · 2012: 17
FWCI
6.06
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of the Neurological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
Alzheimer's disease, synaptic loss, neuronal density, frontal cortex, temporal cortex, cortical atrophy, early-stage dementia, cortical pathology
MeSH terms
Aged, Alzheimer Disease, Biopsy, Cell Count, Cerebral Cortex, Female, Frontal Lobe, Humans, Male, Middle Aged, Neurons, Synapses, Temporal Lobe

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