The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Patterns of Growth Hormone-Eeleasing Factor and Somatostatin Secretion into the Hypophysial-Portal Circulation of the Rat
Abstract
The interrelation between the secretion of two hypophysiotropic peptides, growth hormone-releasing factor (GRF) and somatostatin (SRIF), in the generation of episodic growth hormone (GH) secretion was inferred from direct measurements of immunoreactive GRF and immunoreactive SRIF concentrations in the hypophysial-portal plasma of the rat. Secretion of immunoreactive GRF was found to be episodic, with maximal concentrations present during periods of expected GH secretory episodes. Secretion of immunoreactive GRF was accompanied by a moderate reduction in portal plasma levels of immunoreactive SRIF. Passive immunoneutralization of SRIF was associated with increased concentrations of immunoreactive GRF in hypophysial-portal plasma. On the basis of these observations, it appears that each GH secretory episode is initiated by pulsatile secretion of immunoreactive GRF into the portal circulation, which is preceded by or is concurrent with a moderate reduction of inhibitory tone provided by portal immunoreactive SRIF. These experiments provide direct insights into central and adenohypophysial mechanisms by which GRF and SRIF interact to generate episodic secretion of GH.
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Cites
Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone
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Self-citationGrowth Hormone-Releasing Factor from a Human Pancreatic Tumor That Caused Acromegaly
Guillemin, R., Brazeau, P., Bohlen, P., Esch, F., Ling, N., & Wehrenberg, W. B. (1982) · Science · doi:10.1126/science.6812220 · Cited by 1,294
Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour
Rivier, J., Spiess, J., Thorner, M., & Vale, W. (1982) · Nature · doi:10.1038/300276a0 · Cited by 1,104
Self-citationNEURAL CONTROL OF THE PITUITARY GLAND
Harris, G. W. (1948) · Physiological Reviews · doi:10.1152/physrev.1948.28.2.139 · Cited by 911
Evidence for an Endogenous Ultradian Rhythm Governing Growth Hormone Secretion in the Rat
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TANNENBAUM, G. S., & LING, N. (1984) · Endocrinology · doi:10.1210/endo-115-5-1952 · Cited by 524
Characterization of rat hypothalamic growth hormone-releasing factor
Spiess, J., Rivier, J., & Vale, W. (1983) · Nature · doi:10.1038/303532a0 · Cited by 371
Self-citationPhysiological role of somatostatin in the control of growth hormone and thyrotropin secretion
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Giustina, A., & Veldhuis, J. D. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.6.0353 · Cited by 1,253
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Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930
IRANMANESH, A., LIZARRALDE, G., & VELDHUIS, J. D. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1081 · Cited by 672
Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility
Gjerstad, J. K., Lightman, S. L., & Spiga, F. (2018) · Stress · doi:10.1080/10253890.2018.1470238 · Cited by 437
MAURAS, N., BLIZZARD, R. M., LINK, K., JOHNSON, M. L., ROGOL, A. D., & VELDHUIS, J. D. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-3-596 · Cited by 300
Metadata
- Authors
- Plotsky, P. M., & Vale, W.
- Venue
- Science
- Published
- 1985-10-25
- Volume
- 230
- Issue
- 4724
- Pages
- 461-463
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2089845502
- Cited by
- 538
- References
- 24
- FWCI
- 19.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Patterns of Growth Hormone-Eeleasing Factor and Somatostatin Secretion into the Hypophysial-Portal Circulation of the Rat. https://app.cochat.ai/papers/10.1126/science.2864742
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- Plotsky, P. M., & Vale, W. (1985). Patterns of Growth Hormone-Eeleasing Factor and Somatostatin Secretion into the Hypophysial-Portal Circulation of the Rat. Science. https://doi.org/10.1126/science.2864742
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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