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A H + -Gated Urea Channel: The Link Between Helicobacter pylori Urease and Gastric Colonization
Abstract
Acidic media trigger cytoplasmic urease activity of the unique human gastric pathogen Helicobacter pylori. Deletion of ureI prevents this activation of cytoplasmic urease that is essential for bacterial acid resistance. UreI is an inner membrane protein with six transmembrane segments as shown by in vitro transcription/translation and membrane separation. Expression of UreI in Xenopus oocytes results in acid-stimulated urea uptake, with a pH profile similar to activation of cytoplasmic urease. Mutation of periplasmic histidine 123 abolishes stimulation. UreI-mediated transport is urea specific, passive, nonsaturable, nonelectrogenic, and temperature independent. UreI functions as a H + -gated urea channel regulating cytoplasmic urease that is essential for gastric survival and colonization.
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Cited by
Pathogenesis of Helicobacter pylori Infection
Kusters, J. G., van Vliet, A. H. M., & Kuipers, E. J. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00054-05 · Cited by 2,526
Molecular aspects of bacterial pH sensing and homeostasis
Krulwich, T. A., Sachs, G., & Padan, E. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2549 · Cited by 1,042
Self-citationErnst, P. B., & Gold, B. D. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.615 · Cited by 554
Helicobacter pylori infection: An overview of bacterial virulence factors and pathogenesis
Kao, C.-Y., Sheu, B.-S., & Wu, J.-J. (2016) · Biomedical Journal · doi:10.1016/j.bj.2015.06.002 · Cited by 513
Alkali production by oral bacteria and protection against dental caries
Burne, R. A., & Marquis, R. E. (2000) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2000.tb09393.x · Cited by 400
Metadata
- Authors
- Weeks, D. L., Eskandari, S., Scott, D. R., & Sachs, G.
- Venue
- Science
- Published
- 2000-01-21
- Volume
- 287
- Issue
- 5452
- Pages
- 482-485
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1591145736
- Cited by
- 519
- References
- 0
- FWCI
- 36.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weeks, D. L., Eskandari, S., Scott, D. R., & Sachs, G. (2000). A H + -Gated Urea Channel: The Link Between Helicobacter pylori Urease and Gastric Colonization. Science. https://doi.org/10.1126/science.287.5452.482
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
