Cited by 400Oral microbiology and periodontitis researchDental Health and Care UtilizationBacterial biofilms and quorum sensing

Alkali production by oral bacteria and protection against dental caries

Burne, Robert A, Marquis, Robert E·2000·FEMS Microbiology Letters

Abstract

pH is a key environmental factor affecting the physiology, ecology and pathogenicity of the oral biofilms colonizing the hard tissues of the human mouth. Much attention has been focused on the production of organic acids through the metabolism of carbohydrates by pathogenic oral bacteria. Now, evidence is emerging that alkali generation, particularly through ammonia production from arginine and urea, plays major roles in pH homeostasis in oral biofilms and may moderate initiation and progression of dental caries. This short review highlights recent progress on understanding molecular genetic and physiologic aspects of ammonia generation by prominent oral bacteria.

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Crossref · 10.1111/j.1574-6968.2000.tb09393.x

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38 of 38 references verified0 citation errors · 0 not checkable

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  • Some commensal organisms are able to buffer the acid produced by caries-associated bacteria by raising the pH of saliva through the production of alkaline metabolic by-products.

    “Some commensal organisms are able to buffer the acid produced by caries‐associated bacteria by raising the pH of saliva through the production of alkaline metabolic by‐products.175”

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Authors
Burne, R. A., & Marquis, R. E.
Affiliations
University of Rochester Medicine (US)
Corresponding author
Burne, Robert A
Venue
FEMS Microbiology Letters
Published
2000-12
Volume
193
Issue
1
Pages
1-6
ISSN
  • 0378-1097 (ISSN-L)
  • 1574-6968
OpenAlex
W2156053584
Cited by
400
References
38
Citations by year
2026: 13 · 2025: 23 · 2024: 20 · 2023: 17 · 2022: 35 · 2021: 27 · 2020: 25 · 2019: 21 · 2018: 28 · 2017: 28 · 2016: 24 · 2015: 16 · 2014: 21 · 2013: 13 · 2012: 14
FWCI
4.11
Type
journal article
Language
en
Open access
closed
Locations
  • FEMS Microbiology Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Dental and Craniofacial Research (DE-06127, DE 10362, R01DE006127, R01DE010362)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords
alkali production, ammonia synthesis, oral bacteria, dental caries, dental plaque, pH homeostasis, arginine metabolism, urea metabolism, organic acid production, cariogenic bacteria
MeSH terms
Ammonia, Bacteria, Cell Membrane, Dental Caries, Dental Plaque, Enzyme Inhibitors, Fluorides, Humans, Hydrogen-Ion Concentration, Hydrolases, Tooth, Urease, Biofilms

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