The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Adaptive Recognition by Nucleic Acid Aptamers
Abstract
Nucleic acid molecules play crucial roles in diverse biological processes including the storage, transport, processing, and expression of the genetic information. Nucleic acid aptamers are selected in vitro from libraries containing random sequences of up to a few hundred nucleotides. Selection is based on the ability to bind ligand molecules with high affinity and specificity. Three-dimensional structures have been determined at high resolution for a number of aptamers in complex with their cognate ligands. Structures of aptamer complexes reveal the key molecular interactions conferring specificity to the aptamer-ligand association, including the precise stacking of flat moieties, specific hydrogen bonding, and molecular shape complementarity. These basic principles of discriminatory molecular interactions in aptamer complexes parallel recognition events central to many cellular processes involving nucleic acids.
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Cites
The three-dimensional structure of the bacterial virus MS2
Valegård, K., Liljas, L., Fridborg, K., & Unge, T. (1990) · Nature · doi:10.1038/345036a0 · Cited by 411
Cited by
Aptamer-based targeted therapy
Zhu, G., & Chen, X. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.08.005 · Cited by 522
RNA–Amino Acid Binding: A Stereochemical Era for the Genetic Code
Yarus, M., Widmann, J. J., & Knight, R. (2009) · Journal of Molecular Evolution · doi:10.1007/s00239-009-9270-1 · Cited by 198
Aptamers selected for higher-affinity binding are not more specific for the target ligand
Carothers, J. M., Oestreich, S. C., & Szostak, J. W. (2006) · Journal of the American Chemical Society · doi:10.1021/ja060952q · Cited by 132
Solution structure of an informationally complex high-affinity RNA aptamer to GTP
CAROTHERS, J. M., DAVIS, J. H., CHOU, J. J., & SZOSTAK, J. W. (2006) · RNA · doi:10.1261/rna.2251306 · Cited by 78
Evolutionary landscapes for the acquisition of new ligand recognition by RNA aptamers
Held, D. M., Travis Greathouse, S., Agrawal, A., & Burke, D. H. (2003) · Journal of Molecular Evolution · doi:10.1007/s00239-003-2481-y · Cited by 41
Metadata
- Authors
- Hermann, T., & Patel, D. J.
- Venue
- Science
- Published
- 2000-02-04
- Volume
- 287
- Issue
- 5454
- Pages
- 820-825
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2010120270
- Cited by
- 1,650
- References
- 1
- FWCI
- 11.27
- Type
- journal article
- Language
- en
- Open access
- closed
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