The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis
Open accessAbstract
Morphologic polarity is necessary for chemotaxis of mammalian cells. As a probe of intracellular signals responsible for this asymmetry, the pleckstrin homology domain of the AKT protein kinase (or protein kinase B), tagged with the green fluorescent protein (PHAKT-GFP), was expressed in neutrophils. Upon exposure of cells to chemoattractant, PHAKT-GFP is recruited selectively to membrane at the cell's leading edge, indicating an internal signaling gradient that is much steeper than that of the chemoattractant. Translocation of PHAKT-GFP is inhibited by toxin-B from Clostridium difficile , indicating that it requires activity of one or more Rho guanosine triphosphatases.
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Cites
Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes
Cox, D., Chang, P., Zhang, Q., Reddy, P. G., Bokoch, G. M., & Greenberg, S. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1487 · Cited by 436
Cited by
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Self-citationSynthesis and Function of 3-Phosphorylated Inositol Lipids
Vanhaesebroeck, B., Leevers, S. J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P. C., Woscholski, R., Parker, P. J., & Waterfield, M. D. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.535 · Cited by 1,535
Cell migration: Rho GTPases lead the way
Raftopoulou, M., & Hall, A. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2003.06.003 · Cited by 1,235
Role of Bruton’s tyrosine kinase in B cells and malignancies
Pal Singh, S., Dammeijer, F., & Hendriks, R. W. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0779-z · Cited by 726
Neuronal polarity: from extracellular signals to intracellular mechanisms.
Arimura, N., & Kaibuchi, K. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2056 · Cited by 655
Metadata
- Authors
- Servant, G., Weiner, O. D., Herzmark, P., Balla, T., Sedat, J. W., & Bourne, H. R.
- Venue
- Science
- Published
- 2000-02-11
- Volume
- 287
- Issue
- 5455
- Pages
- 1037-1040
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2151519283
- Cited by
- 877
- References
- 1
- FWCI
- 23.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Servant, G., Weiner, O. D., Herzmark, P., Balla, T., Sedat, J. W., & Bourne, H. R. (2000). Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis. Science. https://doi.org/10.1126/science.287.5455.1037
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
