Neuronal polarity: from extracellular signals to intracellular mechanisms.
Abstract
After they are born and differentiate, neurons break their previous symmetry, dramatically change their shape, and establish two structurally and functionally distinct compartments - axons and dendrites - within one cell. How do neurons develop their morphologically and molecularly distinct compartments? Recent studies have implicated several signalling pathways evoked by extracellular signals as having essential roles in a number of aspects of neuronal polarization.
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Several signaling cascades that direct the establishment of neuronal polarity have been identified.
“Several signaling cascades that direct the establishment of neuronal polarity have been identified (Arimura and Kaibuchi, 2007).”
From Rassf5 and Ndr kinases act in a novel pathway regulating neuronal polarity through Par3 phosphorylation (2014) · cites this paper as Arimura and Kaibuchi, 2007
Cites
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“Kinesin 1 (previously called 'kinesin' or 'conventional kinesin') is a microtubule plus-end-directed moto”
BackgroundHippocampal Neuronal Polarity Specified by Spatially Localized mPar3/mPar6 and PI 3-Kinase Activity
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Schwamborn, J. C., & Püschel, A. W. (2004) · Nature Neuroscience · doi:10.1038/nn1295 · Cited by 385 · see citing works
p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase
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Microtubule stabilization specifies initial neuronal polarization
Witte, H., Neukirchen, D., & Bradke, F. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200707042 · Cited by 564 · see citing works
The axon initial segment and the maintenance of neuronal polarity
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Neurofascin assembles a specialized extracellular matrix at the axon initial segment
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NOS1AP associates with Scribble and regulates dendritic spine development
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Identification and characterization of a neuron-specific isoform of protrudin
Ohnishi, T., Shirane, M., Hashimoto, Y., Saita, S., & Nakayama, K. I. (2014) · Genes to Cells · doi:10.1111/gtc.12109 · Cited by 33 · see citing works
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- Authors
- Arimura, N., & Kaibuchi, K.
- Affiliations
- Nagoya University (JP)
- Corresponding author
- Kaibuchi, Kozo
- Venue
- Nature Reviews Neuroscience
- Published
- 2007-03
- Volume
- 8
- Issue
- 3
- Pages
- 194-205
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2087277008
- Cited by
- 655
- References
- 5
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 22 · 2023: 18 · 2022: 26 · 2021: 18 · 2020: 28 · 2019: 21 · 2018: 27 · 2017: 33 · 2016: 25 · 2015: 40 · 2014: 43 · 2013: 58 · 2012: 63
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neuronal polarity, neurite outgrowth, extracellular signalling, intracellular signaling, positive and negative feedback loops, neuronal morphology, axons, dendrites
- MeSH terms
- Animals, Models, Biological, Neurons, Signal Transduction, Cell Polarity, Protein Transport
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