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Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis
Open accessAbstract
Morphologic polarity is necessary for chemotaxis of mammalian cells. As a probe of intracellular signals responsible for this asymmetry, the pleckstrin homology domain of the AKT protein kinase (or protein kinase B), tagged with the green fluorescent protein (PHAKT-GFP), was expressed in neutrophils. Upon exposure of cells to chemoattractant, PHAKT-GFP is recruited selectively to membrane at the cell's leading edge, indicating an internal signaling gradient that is much steeper than that of the chemoattractant. Translocation of PHAKT-GFP is inhibited by toxin-B from Clostridium difficile , indicating that it requires activity of one or more Rho guanosine triphosphatases.
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Metadata
- Authors
- Servant, G., Weiner, O. D., Herzmark, P., Balla, T., Sedat, J. W., & Bourne, H. R.
- Venue
- Science
- Published
- 2000-02-11
- Volume
- 287
- Issue
- 5455
- Pages
- 1037-1040
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2151519283
- Cited by
- 877
- References
- 1
- FWCI
- 23.54
- Type
- journal article
- Language
- en
- Open access
- green
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