The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Ethanol-Induced Apoptotic Neurodegeneration and Fetal Alcohol Syndrome
Abstract
The deleterious effects of ethanol on the developing human brain are poorly understood. Here it is reported that ethanol, acting by a dual mechanism [blockade of N -methyl- d -aspartate (NMDA) glutamate receptors and excessive activation of GABA A receptors], triggers widespread apoptotic neurodegeneration in the developing rat forebrain. Vulnerability coincides with the period of synaptogenesis, which in humans extends from the sixth month of gestation to several years after birth. During this period, transient ethanol exposure can delete millions of neurons from the developing brain. This can explain the reduced brain mass and neurobehavioral disturbances associated with human fetal alcohol syndrome.
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Citations
Cites
Comparative aspects of the brain growth spurt
Dobbing, J., & Sands, J. (1979) · Early Human Development · doi:10.1016/0378-3782(79)90022-7 · Cited by 2,506
Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain
Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vöckler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L., & Olney, J. W. (1999) · Science · doi:10.1126/science.283.5398.70 · Cited by 2,055
Self-citationNew stereological methods for counting neurons
West, M. J. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90112-o · Cited by 940
Effects of Moderate Alcohol Consumption on the Central Nervous System*
Eckardt, M. J., File, S. E., Gessa, G. L., Grant, K. A., Guerri, C., Hoffman, P. L., Kalant, H., Koob, G. F., Li, T., & Tabakoff, B. (1998) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03695.x · Cited by 622
Cited by
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
Jevtovic-Todorovic, V., Hartman, R. E., Izumi, Y., Benshoff, N. D., Dikranian, K., Zorumski, C. F., Olney, J. W., & Wozniak, D. F. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00876.2003 · Cited by 1,983
Self-citationAdult neurogenesis: from precursors to network and physiology
Abrous, D. N., Koehl, M., & Le Moal, M. (2005) · Physiological Reviews · doi:10.1152/physrev.00055.2003 · Cited by 971
Environmental risk factors for attention‐deficit hyperactivity disorder
Banerjee, T. D., Middleton, F., & Faraone, S. V. (2007) · Acta Paediatrica · doi:10.1111/j.1651-2227.2007.00430.x · Cited by 575
Satomoto, M., Satoh, Y., Terui, K., Miyao, H., Takishima, K., Ito, M., & Imaki, J. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181974fa2 · Cited by 496
Metadata
- Authors
- Ikonomidou, C., Bittigau, P., Ishimaru, M. J., Wozniak, D. F., Koch, C., Genz, K., Price, M. T., Stefovska, V., Hörster, F., Tenkova, T., Dikranian, K., & Olney, J. W.
- Venue
- Science
- Published
- 2000-02-11
- Volume
- 287
- Issue
- 5455
- Pages
- 1056-1060
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2162665706
- Cited by
- 1,371
- References
- 4
- FWCI
- 65.51
- Type
- journal article
- Language
- en
- Open access
- closed
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