The DOI matches its Crossref record.
Virus-Induced Neuronal Apoptosis Blocked by the Herpes Simplex Virus Latency-Associated Transcript
Abstract
Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript ( LAT ) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT − virus but not with LAT + viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.
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Citations
Cited by
(2014) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-53488-0.00011-0 · Cited by 474
Cohen, J. I. (2020) · Journal of Clinical Investigation · doi:10.1172/jci136225 · Cited by 280
Inhibition of HSV-1 Replication by Gene Editing Strategy
Roehm, P. C., Shekarabi, M., Wollebo, H. S., Bellizzi, A., He, L., Salkind, J., & Khalili, K. (2016) · Scientific Reports · doi:10.1038/srep23146 · Cited by 128
Gene Delivery Using Herpes Simplex Virus Vectors
Burton, E. A., Fink, D. J., & Glorioso, J. C. (2002) · DNA and Cell Biology · doi:10.1089/104454902762053864 · Cited by 92
Metadata
- Authors
- Perng, G.-C., Jones, C., Ciacci-Zanella, J., Stone, M., Henderson, G., Yukht, A., Slanina, S. M., Hofman, F. M., Ghiasi, H., Nesburn, A. B., & Wechsler, S. L.
- Venue
- Science
- Published
- 2000-02-25
- Volume
- 287
- Issue
- 5457
- Pages
- 1500-1503
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2126134216
- Cited by
- 469
- References
- 0
- FWCI
- 20.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Virus-Induced Neuronal Apoptosis Blocked by the Herpes Simplex Virus Latency-Associated Transcript. https://app.cochat.ai/papers/10.1126/science.287.5457.1500
- The paper
- Perng, G.-C., Jones, C., Ciacci-Zanella, J., Stone, M., Henderson, G., Yukht, A., Slanina, S. M., Hofman, F. M., Ghiasi, H., Nesburn, A. B., & Wechsler, S. L. (2000). Virus-Induced Neuronal Apoptosis Blocked by the Herpes Simplex Virus Latency-Associated Transcript. Science. https://doi.org/10.1126/science.287.5457.1500
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
