The DOI matches its Crossref record.
The Calcium Entry Pas de Deux
Abstract
The careful regulation of calcium ion entry by the cell is essential for activation of numerous signal transduction cascades. It is well-established that the depletion of internal calcium ion stores such as those of the endoplasmic reticulum (ER) results in the opening of plasma membrane channels (SOCs) allowing calcium ions to flow into the cell. However, the mechanism by which calcium ion store depletion and the opening of SOCs are coupled is not clear. In a Perspective, Berridge and colleagues discuss new findings (Ma et al.) demonstrating that the inositol trisphosphate receptor in the ER membrane forms a physical connection with the SOCs in the plasma membrane. Inhibitors that block activation of inositol trisphosphate receptors prevent opening of SOCs in response to depletion of internal calcium stores.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons
Verkhratsky, A. (2005) · Physiological Reviews · doi:10.1152/physrev.00004.2004 · Cited by 709
Astrocyte calcium waves: What they are and what they do
Scemes, E., & Giaume, C. (2006) · Glia · doi:10.1002/glia.20374 · Cited by 600
Xu, S.-Z., & Beech, D. J. (2001) · Circulation Research · doi:10.1161/01.res.88.1.84 · Cited by 361
Resende, R., Ferreiro, E., Pereira, C., & Resende de Oliveira, C. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.036 · Cited by 235
Watanabe, D., Hashimoto, S., Ishiai, M., Matsushita, M., Baba, Y., Kishimoto, T., Kurosaki, T., & Tsukada, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103675200 · Cited by 136
Metadata
- Authors
- Berridge, M. J., Lipp, P., & Bootman, M. D.
- Venue
- Science
- Published
- 2000-03-03
- Volume
- 287
- Issue
- 5458
- Pages
- 1604-1605
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1971072079
- Cited by
- 182
- References
- 0
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Calcium Entry Pas de Deux. https://app.cochat.ai/papers/10.1126/science.287.5458.1604
- The paper
- Berridge, M. J., Lipp, P., & Bootman, M. D. (2000). The Calcium Entry Pas de Deux. Science. https://doi.org/10.1126/science.287.5458.1604
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
