The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Drosophila Mechanosensory Transduction Channel
Abstract
Mechanosensory transduction underlies a wide range of senses, including proprioception, touch, balance, and hearing. The pivotal element of these senses is a mechanically gated ion channel that transduces sound, pressure, or movement into changes in excitability of specialized sensory cells. Despite the prevalence of mechanosensory systems, little is known about the molecular nature of the transduction channels. To identify such a channel, we analyzed Drosophila melanogaster mechanoreceptive mutants for defects in mechanosensory physiology. Loss-of-function mutations in the no mechanoreceptor potential C ( nompC ) gene virtually abolished mechanosensory signaling. nompC encodes a new ion channel that is essential for mechanosensory transduction. As expected for a transduction channel, D. melanogaster NOMPC and a Caenorhabditis elegans homolog were selectively expressed in mechanosensory organs.
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Cites
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589
Molecular Identification of a Eukaryotic, Stretch-Activated Nonselective Cation Channel
Kanzaki, M., Nagasawa, M., Kojima, I., Sato, C., Naruse, K., Sokabe, M., & Iida, H. (1999) · Science · doi:10.1126/science.285.5429.882 · Cited by 213
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Patapoutian, A., Peier, A. M., Story, G. M., & Viswanath, V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1141 · Cited by 873
Mechanically Activated Ion Channels
Ranade, S. S., Syeda, R., & Patapoutian, A. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.032 · Cited by 652
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Jin, S., Sun, Y., Liang, X., Gu, X., Ning, J., Xu, Y., Chen, S., & Pan, L. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00868-x · Cited by 459
The neural basis of Drosophila gravity-sensing and hearing
Kamikouchi, A., Inagaki, H. K., Effertz, T., Hendrich, O., Fiala, A., Göpfert, M. C., & Ito, K. (2009) · Nature · doi:10.1038/nature07810 · Cited by 406
How do fibroblasts translate mechanical signals into changes in extracellular matrix production?
Chiquet, M., Renedo, A. S., Huber, F., & Flück, M. (2003) · Matrix Biology · doi:10.1016/s0945-053x(03)00004-0 · Cited by 391
Metadata
- Authors
- Walker, R. G., Willingham, A. T., & Zuker, C. S.
- Venue
- Science
- Published
- 2000-03-24
- Volume
- 287
- Issue
- 5461
- Pages
- 2229-2234
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006501334
- Cited by
- 696
- References
- 2
- FWCI
- 16.05
- Type
- journal article
- Language
- en
- Open access
- closed
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