Molecular Identification of a Eukaryotic, Stretch-Activated Nonselective Cation Channel
Abstract
Calcium-permeable, stretch-activated nonselective cation (SA Cat) channels mediate cellular responses to mechanical stimuli. However, genes encoding such channels have not been identified in eukaryotes. The yeast MID1 gene product (Mid1) is required for calcium influx in the yeast Saccharomyces cerevisiae . Functional expression of Mid1 in Chinese hamster ovary cells conferred sensitivity to mechanical stress that resulted in increases in both calcium conductance and the concentration of cytosolic free calcium. These increases were dependent on the presence of extracellular calcium and were reduced by gadolinium, a blocker of SA Cat channels. Single-channel analyses with cell-attached patches revealed that Mid1 acts as a calcium-permeable, cation-selective stretch-activated channel with a conductance of 32 picosiemens at 150 millimolar cesium chloride in the pipette. Thus, Mid1 appears to be a eukaryotic, SA Cat channel.
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Under Ca2+-depleted conditions, Mid1 did not promote influx of divalent cations when expressed alone, indicating Mid1 does not have independent channel activity under these conditions.
“Under Ca 2ϩ -depleted conditions, Mid1 did not promote the influx of divalent cations when expressed on its own, indicating that Mid1 does not have any independent channel activity under these particular conditions (39).”
From Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress (2010) · cites this paper as [39]
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“However, MID1 has also been claimed to function independently as stretchactivated Ca2+-permeable channel localized largely in the ER (Kanzaki et al., 1999; Yoshimura et al., 2004).”
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“Data were collected in States-TPPI mode (Kanzaki et al., 1999) for quadrature detection.”
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“We found that amiodarone, one of the most effective antiarrhythmic agents currently available for chronic treatment of arrhythmias (Kodama et al ., 1999), has fungicidal activity against a broad array of fungi, including yeast (Courchesne, 2002).”
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“expressed in COS7 cells and in CHO cells (25).”
BackgroundEstimating the Sensitivity of Mechanosensitive Ion Channels to Membrane Strain and Tension
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“Although uncommon, such long openings have also been observed in CHO cells transfected with the yeast stretch-activated cation channel MID1 (Kanzaki et al., 1999).”
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“We tested several K channel inhibitors, including 4-PA (1 mM), which is a nonselective K channel inhibitor, and TEA (15 mM) and Gd(3) (1 mM), which are yeast potassium and stretch-activated cation channel inhibitors, respectively (10, 13).”
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Phospholipase C is required for glucose‐induced calcium influx in budding yeast
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Exogenous oxidative stress induces Ca2+ release in the yeast Saccharomyces cerevisiae
Popa, C., Dumitru, I., Ruta, L. L., Danet, A. F., & FARCASANU, I. C. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07794.x · Cited by 67 · see citing works
Avian magnetite-based magnetoreception: a physiologist's perspective
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Is PECAM-1 a Mechanoresponsive Molecule?
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“The apical plaque is a site where the apical stress fibers are anchored to the apical plasma membrane and are present in both cultured (Katoh et al., 1995) and in situ (Kano et al., 1996) endothelial cells.”
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The Impact of Altered Gravity and Vibration on Endothelial Cells During a Parabolic Flight
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“Because all eukaryotic and prokaryotic cells possess mechanosensitive channels that detect mechanical forces acting on the cell [29], it is possible that mechanical stress impacts the survival and differentiation of donor stem cells after their delivery into a failing heart, which ultimately affects the potency of ste…”
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“Mechanical stress activates several intracellular signaling through mechanoreceptors.(16,17) However, the effects of mechanical stress on the differentiation of DPSCs are controversial.”
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“At this time, the mechanism of extracellular calcium influx in response to mechanical stretch has not been established but may involve the contribution of stretch-gated calcium channels such as an eukaryotic calcium-permeable stretch-activated cation channel (Mid1) that has been identified in yeast Saccharomyces cerev…”
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Calcium signaling mediates the response to cadmium toxicity in Saccharomyces cerevisiae cells
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“The cells of Saccharomyces cerevisiae, one of the model eukaryotic microorganisms often used to decipher highly conserved mechanisms, use Ca as a second messenger when they are exposed to various environmental stimuli such as hypotonic stress [1], cold stress [2], hyperosmotic and salt stress [3], b-phenylethylamine-i…”
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BackgroundQuantitative description of ion transport via plasma membrane of yeast and small cells
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Phenotype of a Mechanosensitive Channel Mutant, mid - 1 , in a Filamentous Fungus, Neurospora crassa
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“The yeast Mid1p product was identified as a stretch-activated channel based on patch clamp measurements after heterologous expression in mammalian CHO cells ( 11 ).”
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The osmotic stress response of Saccharomyces cerevisiae
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Signal perception, transduction, and response in gravity resistance. Another graviresponse in plants
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“The existence of mechanosensors has been reported in yeast (Kanzaki et al., 1999; Paidhungat and Garrett, 1997).”
Background
- Authors
- Kanzaki, M., Nagasawa, M., Kojima, I., Sato, C., Naruse, K., Sokabe, M., & Iida, H.
- Affiliations
- Gunma University (JP)
- Supermolecular Science Division, Electrotechnical Laboratory, Tsukuba, Ibaraki 305-8568, Japan.
- Nagoya University (JP)
- Tokyo Gakugei University (JP)
- Corresponding author
- Iida, Hidetoshi
- Venue
- Science
- Published
- 1999-08-06
- Volume
- 285
- Issue
- 5429
- Pages
- 882-886
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026402396
- Cited by
- 213
- References
- 23
- Citations by year
- 2025: 2 · 2024: 3 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 9 · 2013: 9 · 2012: 9
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
- Keywords
- stretch-activated channels, non-selective cation channels, calcium-permeable channels, MID1, Saccharomyces cerevisiae, mechanical stress, calcium influx, gadolinium, single-channel conductance, cation selectivity, cytosolic free calcium
- MeSH terms
- Amino Acid Sequence, Animals, Calcium, Cations, Cell Membrane, Cell Membrane Permeability, Cesium, Chlorides, Fungal Proteins, Gadolinium, Cricetinae, Ion Channels, Membrane Glycoproteins, Membrane Potentials, Molecular Sequence Data, Pressure, Saccharomyces cerevisiae, Stress, Mechanical, Transfection, Calcium Channels, CHO Cells, Zinc Compounds, Patch-Clamp Techniques, Saccharomyces cerevisiae Proteins
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