Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

Mitochondria and Apoptosis

Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 9,051

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289

The Bcl-2 Protein Family: Arbiters of Cell Survival

Adams, J. M., & Cory, S. (1998) · Science · doi:10.1126/science.281.5381.1322 · Cited by 5,334

Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction

Liang, P., & Pardee, A. B. (1992) · Science · doi:10.1126/science.1354393 · Cited by 4,964

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063

BCL-2 family members and the mitochondria in apoptosisPreprint

Gross, A., McDonnell, J. M., & Korsmeyer, S. J. (1999) · Genes & Development · doi:10.1101/gad.13.15.1899 · Cited by 3,642

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

Zou, H., Henzel, W. J., Liu, X., Lutschg, A., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80501-2 · Cited by 3,145

p53 is required for radiation-induced apoptosis in mouse thymocytes

Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864

Thymocyte apoptosis induced by p53-dependent and independent pathways

Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., & Wyllie, A. H. (1993) · Nature · doi:10.1038/362849a0 · Cited by 2,271

Definition of a consensus binding site for p53

El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

Wolter, K. G., Hsu, Y., Smith, C. L., Nechushtan, A., Xi, X., & Youle, R. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.5.1281 · Cited by 1,809

pEF-BOS, a powerful mammalian expression vector

Mizushima, S., & Nagata, S. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.17.5322 · Cited by 1,594

A novel form of Epstein-Barr virus latency in normal B cells in vivo

Miyashita, E. M., Yang, B., Lam, K. M. C., Crawford, D., & Thorley‐Lawson, D. A. (1995) · Cell · doi:10.1016/0092-8674(95)90513-8 · Cited by 1,591

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

Knudson, C. M., Tung, K. S. K., Tourtellotte, W. G., Brown, G. A. J., & Korsmeyer, S. J. (1995) · Science · doi:10.1126/science.270.5233.96 · Cited by 1,492

Is a p53-Regulated Inhibitor of G2/M Progression

Hermeking, H., Lengauer, C., Polyak, K., He, T.-C., Zhang, L., Thiagalingam, S., Kinzler, K. W., & Vogelstein, B. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80002-7 · Cited by 1,251

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD‐specific caspase activation and independently of mitochondrial transmembrane depolarization

Bossy‐Wetzel, E., Newmeyer, D. D., & Green, D. R. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.37 · Cited by 1,225

Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

Srinivasula, S. M., Ahmad, M., Fernandes‐Alnemri, T., & Alnemri, E. S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80095-7 · Cited by 1,119

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

Gross, A., Jockel, J., Wei, M. C., & Korsmeyer, S. J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.14.3878 · Cited by 1,095

Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway

Ulloa, L., Doody, J. F., & Massagué, J. (1999) · Nature · doi:10.1038/17826 · Cited by 812

Conformation of the Bax C‐terminus regulates subcellular location and cell death

Nechushtan, A., Smith, C. L., Hsu, Y., & Youle, R. J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.9.2330 · Cited by 732

Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition

Soengas, M. S., Alarcon, R. M., Yoshida, H., J., A., Giaccia, Hakem, R., Mak, T. W., & Lowe, S. W. (1999) · Science · doi:10.1126/science.284.5411.156 · Cited by 664

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

Heiden, M. G. V., & Thompson, C. B. (1999) · Nature Cell Biology · doi:10.1038/70237 · Cited by 660

Bcl-2-family proteins: the role of the BH3 domain in apoptosis

Kelekar, A., & Thompson, C. B. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01321-x · Cited by 654

The cellular response to p53: the decision between life and death

Sionov, R. V., & Haupt, Y. (1999) · Oncogene · doi:10.1038/sj.onc.1203130 · Cited by 608

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.Preprint

Haupt, Y., Rowan, S., Shaulian, E., Vousden, K. H., & Oren, M. (1995) · Genes & Development · doi:10.1101/gad.9.17.2170 · Cited by 547

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1

Tanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M. S., Aizawa, S., Mak, T. W., & Taniguchi, T. (1994) · Cell · doi:10.1016/0092-8674(94)90132-5 · Cited by 491

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

McCurrach, M. E., Connor, T. M. F., Knudson, C. M., Korsmeyer, S. J., & Lowe, S. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2345 · Cited by 368

Growth factor modulation of p53-mediated growth arrest versus apoptosis.Preprint

Canman, C. E., Gilmer, T. M., Coutts, S. B., & Kastan, M. B. (1995) · Genes & Development · doi:10.1101/gad.9.5.600 · Cited by 365

Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage

Tanaka, N., Ishihara, M., Lamphier, M. S., Nozawa, H., Matsuyama, T., Mak, T. W., Aizawa, S., Tokino, T., Oren, M., & Taniguchi, T. (1996) · Nature · doi:10.1038/382816a0 · Cited by 324

BH3 Domain of BAD Is Required for Heterodimerization with BCL-XL and Pro-apoptotic Activity

Zha, J., Harada, H., Osipov, K. A., Jockel, J., Waksman, G., & Korsmeyer, S. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24101 · Cited by 309

p53 and apoptosis

Gottlieb, T. M., & Oren, M. (1998) · Seminars in Cancer Biology · doi:10.1006/scbi.1998.0098 · Cited by 301

Cancer therapy and p53

Lowe, S. W. (1995) · Current Opinion in Oncology · doi:10.1097/00001622-199511000-00013 · Cited by 193

Protein tyrosine kinase Pyk2 mediates the Jak‐dependent activation of MAPK and Stat1 in IFN‐γ, but not IFN‐α, signaling

Takaoka, A., Tanaka, N., Mitani, Y., Miyazaki, T., Fujii, H., Sato, M., Kovarik, P., Decker, T., Schlessinger, J., & Taniguchi, T. (1999) · The EMBO Journal · doi:10.1093/emboj/18.9.2480 · Cited by 133

T cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage‐induced cell death in the absence of p53.

Brady, H. J. M., Salomons, G. S., Bobeldijk, R. C., & Berns, A. J. M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00463.x · Cited by 125

Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53Preprint

Nozawa, H., Oda, E., Nakao, K., Ishihara, M., Ueda, S., Yokochi, T., Ogasawara, K., Nakatsuru, Y., SHIMIZU, S., Ohira, Y., et al. (1999) · Genes & Development · doi:10.1101/gad.13.10.1240 · Cited by 123

The Cyclin-dependent Kinase Cdk2 Regulates Thymocyte Apoptosis

Hakem, A., Sasaki, T., Kozieradzki, I., & Penninger, J. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.6.957 · Cited by 100

Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathwaysPreprint

Quelle, F. W., Wang, J., Feng, J., Wang, D., Cleveland, J. L., Ihle, J. N., & Zambetti, G. P. (1998) · Genes & Development · doi:10.1101/gad.12.8.1099 · Cited by 96

Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line

Hijikata, M., Kato, N., Sato, T., Kagami, Y., & Shimotohno, K. (1990) · Journal of Virology · doi:10.1128/jvi.64.10.4632-4639.1990 · Cited by 66

Expression of p53 in Saos-2 osteosarcoma cells induces apoptosis which can be inhibited by Bcl-2 or the adenovirus E1B-55 kDa protein.

Marcellus, R. C., Teodoro, J. G., Charbonneau, R., Shore, G. C., & Branton, P. E. (1996) · PubMed · Cited by 55

Differential expression and regulation of chemokines JE, KC, and IP-10 gene in primary cultured murine hepatocytes

Wang, H., Gao, X., Fukumoto, S., Tademoto, S., Sato, K., & Hirai, K. (1999) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199911)181:2 · Cited by 45

Induction of Transformation and p53-Dependent Apoptosis by Adenovirus Type 5 E4orf6/7 cDNA

Yamano, S., Tokino, T., Yasuda, M., Kaneuchi, M., Takahashi, M., Niitsu, Y., Fujinaga, K., & Yamashita, T. (1999) · Journal of Virology · doi:10.1128/jvi.73.12.10095-10103.1999 · Cited by 38

Reduced Mitochondrial Membrane Potential and Altered Responsiveness of a Mitochondrial Membrane Megachannel in p53-Induced Senescence

Sugrue, M. M., Wang, Y., Rideout, H. J., Chalmers-Redman, R. M. E., & Tatton, W. G. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0984 · Cited by 37

Apoptosis: A Review of Programmed Cell Death

Elmore, S. (2007) · Toxicologic Pathology · doi:10.1080/01926230701320337 · Cited by 13,853

Surfing the p53 network

Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607

The BCL-2 protein family: opposing activities that mediate cell death

Youle, R. J., & Strasser, A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2308 · Cited by 4,806

Cell Death

Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651

The Bcl2 family: regulators of the cellular life-or-death switch

Cory, S., & Adams, J. M. (2002) · Nature Reviews Cancer · doi:10.1038/nrc883 · Cited by 4,032

In Harm's Pathway

(2000) · Science s STKE · doi:10.1126/stke.2000.32.tw10

Progress on Pro-Apoptotic Effect of Noxa on Tumor

Yon, D. (2010) · Medical Recapitulate

Synergistic Induction of Apoptosis by p53-inducible Bcl-2 Family Proteins Noxa and Puma

Nakajima, W., & Tanaka, N. (2007) · Journal of Nippon Medical School · doi:10.1272/jnms.74.148 · Cited by 23

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

Villunger, A., Michalak, E. M., Coultas, L., Müllauer, F., Böck, G., Ausserlechner, M. J., Adams, J. M., & Strasser, A. (2003) · Science · doi:10.1126/science.1090072 · Cited by 1,327

Involvement of Bcl-2 Family Proteins in p53-induced Apoptosis

Tobiume, K. (2005) · Journal of Nippon Medical School · doi:10.1272/jnms.72.192 · Cited by 14