Neuronal Plasticity: Increasing the Gain in Pain

The capsaicin receptor: a heat-activated ion channel in the pain pathway

Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

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Long-Term Potentiation--A Decade of Progress?

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Neuropathic pain: aetiology, symptoms, mechanisms, and management

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Evidence for a central component of post-injury pain hypersensitivity

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A capsaicin-receptor homologue with a high threshold for noxious heat

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Peripheral nerve injury triggers central sprouting of myelinated afferents

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The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways

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Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity

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Messenger plasticity in primary sensory neurons following axotomy and its functional implications

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Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors.

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Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons

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NMDA Channel Regulation by Channel-Associated Protein Tyrosine Kinase Src

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Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons

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Myelinated afferents signal the hyperalgesia associated with nerve injury

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Postsynaptic protein phosphorylation and LTP

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Transcriptional and posttranslational plasticity and the generation of inflammatory pain

Woolf, C. J., & Costigan, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7723 · Cited by 555

PGE2 modulates the tetrodotoxin‐resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP‐protein kinase A cascade.

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Long-term potentiation and long-term depression of primary afferent neurotransmission in the rat spinal cord

Randić, M., Jiang, M., & Cerne, R. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-12-05228.1993 · Cited by 521

Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery

Stubhaug, A., Breivik, H., Eide, P. K., KREUNEN, M., & Foss, A. (1997) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.1997.tb04854.x · Cited by 514

H+-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels

Waldmann, R., & Lazdunski, M. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80070-6 · Cited by 511

Differential Expression of the mRNA for the Vanilloid Receptor Subtype 1 in Cells of the Adult Rat Dorsal Root and Nodose Ganglia and Its Downregulation by Axotomy

Michael, G. J., & Priestley, J. V. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-05-01844.1999 · Cited by 508

Brain-Derived Neurotrophic Factor Modulates Nociceptive Sensory Inputs and NMDA-Evoked Responses in the Rat Spinal Cord

Kerr, B. J., Bradbury, E. J., Bennett, D., Trivedi, P. M., Dassan, P., French, J., Shelton, D., McMahon, S. B., & Thompson, S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05138.1999 · Cited by 439

Neurotrophins: Peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity

Mannion, R., Costigan, M., Décosterd, I., Amaya, F., Ma, Q., Holstege, J. C., Ji, R., Acheson, A. L., Lindsay, R. M., Wilkinson, G. A., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9385 · Cited by 432

Specific Involvement of PKC-ε in Sensitization of the Neuronal Response to Painful Heat

Cesare, P., Dekker, L. V., Sardini, A., Parker, P. J., & McNaughton, P. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80813-2 · Cited by 405

G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors

Lu, W.-Y., Xiong, Z.-G., Lei, S., Orser, B. A., Dudek, E. M., Browning, M. D., & MacDonald, J. F. (1999) · Nature Neuroscience · doi:10.1038/7243 · Cited by 384

Comparison of the Antinociceptive Effects of Pre- and Posttreatment with Intrathecal Morphine and MK801, an NMDA Antagonist, on the Formalin Test in the Rat

Yamamoto, T., & Yaksh, T. L. (1992) · Anesthesiology · doi:10.1097/00000542-199210000-00021 · Cited by 352

Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: effects of a chronic constriction injury, transection, and strychnine

Sugimoto, T., Bennett, G. J., & Kajander, K. C. (1990) · Pain · doi:10.1016/0304-3959(90)91164-e · Cited by 351

ION CHANNELS OF NOCICEPTION

McCleskey, E. W., & Gold, M. S. (1999) · Annual Review of Physiology · doi:10.1146/annurev.physiol.61.1.835 · Cited by 340

Low-Frequency Stimulation of Afferent Aδ-Fibers Induces Long-Term Depression at Primary Afferent Synapses with Substantia Gelatinosa Neurons in the Rat

Sandkühler, J., Chen, J.-G., Cheng, G., & Randić, M. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-16-06483.1997 · Cited by 323

Upregulation of a Silent Sodium Channel After Peripheral, but not Central, Nerve Injury in DRG Neurons

Black, J. A., Cummins, T., Plumpton, C., Chen, Y. H., Hormuzdiar, W. N., Clare, J. J., & Waxman, S. G. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.5.2776 · Cited by 306

Substance P induced by peripheral nerve injury in primary afferent sensory neurons and its effect on dorsal column nucleus neurons

Noguchi, K., Kawai, Y., Fukuoka, T., Senba, E., & Miki, K. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07633.1995 · Cited by 299

Different patterns of hyperalgesia induced by experimental inflammation in human skin

Kilo, S., Schmelz, M., Koltzenburg, M., & Handwerker, H. O. (1994) · Brain · doi:10.1093/brain/117.2.385 · Cited by 293

Mind-brain interaction: Mentalism, yes; dualism, no

Sperry, R. W. (1980) · Neuroscience · doi:10.1016/0306-4522(80)90098-6 · Cited by 289

Epinephrine Produces a β-Adrenergic Receptor-Mediated Mechanical Hyperalgesia and In Vitro Sensitization of Rat Nociceptors

Khasar, S. G., McCarter, G. C., & Levine, J. D. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.3.1104 · Cited by 284

Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord

Woolf, C., & King, A. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-08-02717.1990 · Cited by 278

Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons

Tate, S., Benn, S. C., Hick, C. A., Trezise, D. J., John, V. H., Mannion, R., Costigan, M., Plumpton, C., Grose, D., Gladwell, Z. M., et al. (1998) · Nature Neuroscience · doi:10.1038/3652 · Cited by 278

Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin

Shu, X., & Mendell, L. M. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00701-6 · Cited by 272

Activity‐Dependent Changes in Rat Ventral Horn Neurons in vitro; Summation of Prolonged Afferent Evoked Postsynaptic Depolarizations Produce a D‐2‐Amino‐5‐Phosphonovaleric Acid Sensitive Windup

Thompson, S., King, A. E., & Woolf, C. J. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00453.x · Cited by 270

GABA decreases in the spinal cord dorsal horn after peripheral neurectomy

Castro‐Lopes, J. M., Tavares, I., & Coimbra, A. (1993) · Brain Research · doi:10.1016/0006-8993(93)90167-l · Cited by 266

Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord

Li, P., Wilding, T. J., Kim, S. J., Calejesan, A. A., Huettner, J. E., & Zhuo, M. (1999) · Nature · doi:10.1038/16469 · Cited by 261

Synaptic strengthening through activation of Ca2+ -permeable AMPA receptors

Gu, J., Albuquerque, C., Lee, C. J., & MacDermott, A. B. (1996) · Nature · doi:10.1038/381793a0 · Cited by 236

Junctional versus Extrajunctional Glycine and GABAAReceptor-Mediated IPSCs in Identified Lamina I Neurons of the Adult Rat Spinal Cord

Chéry, N., & Koninck, Y. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07342.1999 · Cited by 226

A tetrodotoxin-resistant sodium current mediates inflammatory pain in the rat

Khasar, S. G., Gold, M. S., & Levine, J. D. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00738-1 · Cited by 214

Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation. Studies with antibody microprobes

Duggan, A. W., Hope, P. J., Jarrott, B., Schaible, H., & Fleetwood‐Walker, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90134-p · Cited by 212

Mechanical and Heat Sensitization of Cutaneous Nociceptors After Peripheral Inflammation in The Rat

Andrew, D., & Greenspan, J. D. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.5.2649 · Cited by 203

AMPA receptor–PDZ interactions in facilitation of spinal sensory synapses

Li, P., Kerchner, G. A., Sala, C., Wei, F., Huettner, J. E., Sheng, M., & Zhuo, M. (1999) · Nature Neuroscience · doi:10.1038/14771 · Cited by 191

NK-1 and NK-3 type tachykinin receptor mRNA expression in the rat spinal cord dorsal horn is increased during adjuvant or formalin- induced nociception

McCarson, K. E., & Krause, J. E. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-02-00712.1994 · Cited by 186

Secondary hyperalgesia to mechanical but not heat stimuli following a capsaicin injection in hairy skin

Ali, Z., Meyer, A. R., & Campbell, N. J. (1996) · Pain · doi:10.1016/s0304-3959(96)03199-5 · Cited by 181

Axotomy results in major changes in BDNF expression by dorsal root ganglion cells: BDNF expression in large trkB and trkC cells, in pericellular baskets, and in projections to deep dorsal horn and dorsal column nuclei

Michael, G. J., Averill, S., Shortland, P. J., Yan, Q., & Priestley, J. V. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00767.x · Cited by 179

cAMP‐dependent phosphorylation of the tetrodotoxin‐resistant voltage‐dependent sodium channel SNS

Fitzgerald, E. M., Okuse, K., Wood, J. N., DOLPHIN, A. C., & Moss, S. J. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0433v.x · Cited by 176

Progressive tactile hypersensitivity: an inflammation-induced incremental increase in the excitability of the spinal cord

Ma, Q., & Woolf, C. J. (1996) · Pain · doi:10.1016/0304-3959(96)03105-3 · Cited by 174

Change in mRNAs for neuropeptides and the GABAA receptor in dorsal root ganglion neurons in a rat experimental neuropathic pain model

Fukuoka, T., Tokunaga, A., Kondo, E., Miki, K., Tachibana, T., & Noguchi, K. (1998) · Pain · doi:10.1016/s0304-3959(98)00111-0 · Cited by 171

Preproenkephalin mrna in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with Fos and Fos-related proteins

Noguchi, K., Dubner, R. A., & Ruda, M. A. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90144-q · Cited by 163

Injured primary sensory neurons switch phenotype for brain-derived neurotrophic factor in the rat

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Ionic Basis for Plateau Potentials in Deep Dorsal Horn Neurons of the Rat Spinal Cord

Morisset, V., & Nagy, F. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07309.1999 · Cited by 156

Rate of rise of the cumulative depolarization evoked by repetitive stimulation of small-caliber afferents is a predictor of action potential windup in rat spinal neurons in vitro

Sivilotti, L. G., Thompson, S., & Woolf, C. J. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.5.1621 · Cited by 148

Sensitization of high mechanothreshold superficial dorsal horn and flexor motor neurones following chemosensitive primary afferent activation

Woolf, C. J., Shortland, P. J., & Sivilotti, L. G. (1994) · Pain · doi:10.1016/0304-3959(94)90195-3 · Cited by 142

Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin

Simone, D. A., Baumann, T., Collins, J. G., & LaMotte, R. H. (1989) · Brain Research · doi:10.1016/0006-8993(89)91293-6 · Cited by 137

The spinal contribution of substance P to the generation and maintenance of inflammatory hyperalgesia in the rat

Traub, R. J. (1996) · Pain · doi:10.1016/0304-3959(96)03076-x · Cited by 122

Src, N-methyl-d-aspartate (NMDA) receptors, and synaptic plasticity

Salter, M. W. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00124-5 · Cited by 118

Synaptic reorganization in the substantia gelatinosa after peripheral nerve neuroma formation: aberrant innervation of lamina II neurons by Abeta afferents.

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Chemical Excitation and Sensitization of Nociceptors

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Involvement of neurokinin receptors in the induction but not the maintenance of mechanical allodynia in rat flexor motoneurones.

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Synaptic Reorganization in the Substantia Gelatinosa After Peripheral Nerve Neuroma Formation: Aberrant Innervation of Lamina II Neurons by Aβ Afferents

Kohama, I., Ishikawa, K., & Kocsis, J. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01538.2000 · Cited by 100

Small-caliber afferent inputs produce a heterosynaptic facilitation of the synaptic responses evoked by primary afferent A-fibers in the neonatal rat spinal cord in vitro

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Carrageenan-induced hyperalgesia is associated with increased cyclo-oxygenase-2 expression in spinal cord

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Rises in [Ca2+]i mediate capsaicin‐ and proton‐induced heat sensitization of rat primary nociceptive neurons

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Peripheral nerve insult induces NMDA receptor-mediated, delayed degeneration in spinal neurons

Azkue, J. J., Zimmermann, M., Hsieh, T.-F., & Herdegen, T. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00260.x · Cited by 82

Central changes in primary afferent fibers following peripheral nerve lesions

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The reorganization of μ opioid receptors in the rat dorsal horn following peripheral axotomy

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Cellular Mechanisms of Sensory Processing

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Chapter 7. Modification of nociceptor responses by inflammatory mediators and second messengers implicated in their action – a study in canine testicular polymodal receptors

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Ultrastructural Analysis of Ectopic Synaptic Boutons Arising From Peripherally Regenerated Primary Afferent Fibers

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Effect of a ?-adrenergic agonist on glucose transport and insulin-responsive glucose transporters (GLUT4) in brown adipose tissue of control and obese fa/fa rats

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Central sensitization: implications for the diagnosis and treatment of pain

Woolf, C. J. (2011) · Pain · doi:10.1016/j.pain.2010.09.030 · Cited by 4,771

Persistent postsurgical pain: risk factors and prevention

Kehlet, H., Jensen, T. S., & Woolf, C. J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68700-x · Cited by 4,086

Central sensitization: a generator of pain hypersensitivity by central neural plasticity

Latremoliere, A., & Woolf, C. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.012 · Cited by 3,913

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

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Molecular mechanisms of nociception

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S CIENCE ’ S C OMPASS ● REVIEW REVIEW: NEUROSCIENCE Neuronal Plasticity: Increasing the Gain in Pain

Woolf, C. J., & Salter, M. W. (2014)

Cellular and molecular mechanisms of central sensitization

Salter, M. W., & Woolf, C. J. (2005) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198515616.003.0004 · Cited by 7

Pain and Plasticity

Ji, R., & Kawasaki, Y. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.01931-8

Transcriptional and posttranslational plasticity and the generation of inflammatory pain

Woolf, C. J., & Costigan, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7723 · Cited by 555

From electrical wiring to plastic neurons: evolving approaches to the study of pain

Jabbur, S. J., & Saadé, N. E. (1999) · Pain · doi:10.1016/s0304-3959(99)00141-4 · Cited by 17