The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Requirement for RORγ in Thymocyte Survival and Lymphoid Organ Development
Abstract
Most developing thymocytes undergo apoptosis because they cannot interact productively with molecules encoded by the major histocompatibility complex. Here, we show that mice lacking the orphan nuclear hormone receptor RORγ lose thymic expression of the anti-apoptotic factor Bcl-xL. RORγ thus regulates the survival of CD4 + 8 + thymocytes and may control the temporal window during which thymocytes can undergo positive selection. RORγ was also required for development of lymph nodes and Peyer's patches, but not splenic follicles. In its absence, there was loss of a population of CD3 – CD4 + CD45 + cells that normally express RORγ and that are likely early progenitors of lymphoid organs. Hence, RORγ has critical functions in T cell repertoire selection and lymphoid organogenesis.
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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
Cited by
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
Self-citationDifferentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
Positive and negative selection of T cells
Starr, T. K., Jameson, S. C., & Hogquist, K. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141107 · Cited by 1,601
The biology of innate lymphoid cells
Artis, D., & Spits, H. (2015) · Nature · doi:10.1038/nature14189 · Cited by 1,634
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
Choi, G. B., Yim, Y. S., Wong, H., Kim, S., Kim, H., Kim, S. V., Hoeffer, C. A., Littman, D. R., & Huh, J. R. (2016) · Science · doi:10.1126/science.aad0314 · Cited by 1,214
“RORγ KO mice lack RORγ/γt expression not only in CD4+ T cells, but also in other lymphoid and non-immune system cells, and they have defective development of secondary and tertiary lymphoid organs (36, 37).”
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Metadata
- Authors
- Sun, Z., Unutmaz, D., Zou, Y.-R., Sunshine, M. J., Pierani, A., Brenner-Morton, S., Mebius, R. E., & Littman, D. R.
- Venue
- Science
- Published
- 2000-06-30
- Volume
- 288
- Issue
- 5475
- Pages
- 2369-2373
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1996713852
- Cited by
- 736
- References
- 1
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sun, Z., Unutmaz, D., Zou, Y.-R., Sunshine, M. J., Pierani, A., Brenner-Morton, S., Mebius, R. E., & Littman, D. R. (2000). Requirement for RORγ in Thymocyte Survival and Lymphoid Organ Development. Science. https://doi.org/10.1126/science.288.5475.2369
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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