The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Sevenless , a Cell-Specific Homeotic Gene of Drosophila , Encodes a Putative Transmembrane Receptor with a Tyrosine Kinase Domain
Abstract
The determination of cell fates during the assembly of the ommatidia in the compound eye of Drosophila appears to be controlled by cell-cell interactions. In this process, the sevenless gene is essential for the development of a single type of photoreceptor cell. In the absence of proper sevenless function the cells that would normally become the R7 photoreceptors instead become nonneuronal cells. Previous morphological and genetic analysis has indicated that the product of the sevenless gene is involved in reading or interpreting the positional information that specifies this particular developmental pathway. The sevenless gene has now been isolated and characterized. The data indicate that sevenless encodes a transmembrane protein with a tyrosine kinase domain. This structural similarity between sevenless and certain hormone receptors suggests that similar mechanisms are involved in developmental decisions based on cell-cell interaction and physiological or developmental changes induced by diffusible factors.
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Cites
The embryonic cell lineage of the nematode Caenorhabditis elegans
Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199
Cited by
Signal Transduction through MAP Kinase Cascades
(1998) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60765-4 · Cited by 1,759
The molecular genetics of embryonic pattern formation in Drosophila
Ingham, P. W. (1988) · Nature · doi:10.1038/335025a0 · Cited by 1,045
Rijsewijk, F., Schuermann, M., Wagenaar, E., Parren, P., Weigel, D., & Nusse, R. (1987) · Cell · doi:10.1016/0092-8674(87)90038-9 · Cited by 931
Wilks, A. F., Harpur, A. G., Kurban, R. R., Ralph, S. J., Zürcher, G., & Ziemiecki, A. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.4.2057 · Cited by 528
Mlodzik, M., Hiromi, Y., Weber, U., Goodman, C. S., & Rubin, G. M. (1990) · Cell · doi:10.1016/0092-8674(90)90737-y · Cited by 457
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Metadata
- Authors
- Hafen, E., Basler, K., Edstroem, J.-E., & Rubin, G. M.
- Venue
- Science
- Published
- 1987-04-03
- Volume
- 236
- Issue
- 4797
- Pages
- 55-63
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2167889770
- Cited by
- 414
- References
- 1
- FWCI
- 18.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hafen, E., Basler, K., Edstroem, J.-E., & Rubin, G. M. (1987). Sevenless , a Cell-Specific Homeotic Gene of Drosophila , Encodes a Putative Transmembrane Receptor with a Tyrosine Kinase Domain. Science. https://doi.org/10.1126/science.2882603
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
