The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Homeo Boxes in the Study of Development
Abstract
The body plan of Drosophila is determined to a large extent by homeotic genes, which specify the identity and spatial arrangement of the body segments. Homeotic genes share a characteristic DNA segment, the homeo box, which encodes a defined domain of the homeotic proteins. The homeo domain seems to mediate the binding to specific DNA sequences, whereby the homeotic proteins exert a gene regulatory function. By isolating the normal Antennapedia gene, fusing its protein-coding sequences to an inducible promoter, and reintroducing this fusion gene into the germline of flies, it has been possible to transform head structures into thoracic structures and to alter the body plan in a predicted way. Sequence homologies suggest that similar genetic mechanisms may control development in higher organisms.
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Citations
Cites
Segmental distribution of bithorax complex proteins during Drosophila development
Beachy, P. A., Helfand, S. L., & Hogness, D. S. (1985) · Nature · doi:10.1038/313545a0 · Cited by 413
Coleman, K. G., Poole, S. J., Weir, M. P., Soeller, W. C., & Kornberg, T. (1987) · Genes & Development · doi:10.1101/gad.1.1.19 · Cited by 153
Cited by
Induction of Ectopic Eyes by Targeted Expression of the eyeless Gene in Drosophila
Halder, G., Callaerts, P., & Gehring, W. J. (1995) · Science · doi:10.1126/science.7892602 · Cited by 1,573
Self-citationBohmann, D., Bos, T. J., Admon, A., Nishimura, T., Vogt, P. K., & Tjian, R. (1987) · Science · doi:10.1126/science.2825349 · Cited by 1,321
The structure and function of the homeodomain
Scott, M. P., Tamkun, J. W., & Hartzell III, G. W. (1989) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(89)90033-4 · Cited by 990
The developmental gene Knotted-1 is a member of a maize homeobox gene family
Vollbrecht, E., Veit, B., Sinha, N., & Hake, S. (1991) · Nature · doi:10.1038/350241a0 · Cited by 759
Müller, M. M., Ruppert, S., Schaffner, W., & Matthias, P. (1988) · Nature · doi:10.1038/336544a0 · Cited by 462
Metadata
- Authors
- Gehring, W. J.
- Venue
- Science
- Published
- 1987-06-05
- Volume
- 236
- Issue
- 4806
- Pages
- 1245-1252
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1975538460
- Cited by
- 899
- References
- 2
- FWCI
- 33.55
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
