The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Structure of the Cytoplasmic β Subunit--T1 Assembly of Voltage-Dependent K + Channels
Abstract
The structure of the cytoplasmic assembly of voltage-dependent K + channels was solved by x-ray crystallography at 2.1 angstrom resolution. The assembly includes the cytoplasmic (T1) domain of the integral membrane α subunit together with the oxidoreductase β subunit in a fourfold symmetric T1 4 β 4 complex. An electrophysiological assay showed that this complex is oriented with four T1 domains facing the transmembrane pore and four β subunits facing the cytoplasm. The transmembrane pore communicates with the cytoplasm through lateral, negatively charged openings above the T1 4 β 4 complex. The inactivation peptides of voltage-dependent K + channels reach their site of action by entering these openings.
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Cites
[20] Processing of X-ray diffraction data collected in oscillation mode
Otwinowski, Z., & Minor, W. (1997) · Methods in Enzymology · doi:10.1016/s0076-6879(97)76066-x · Cited by 33,475
Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons
Armstrong, C. M. (1971) · The Journal of General Physiology · doi:10.1085/jgp.58.4.413 · Cited by 929
Structure of a voltage-dependent K+ channel β subunit
Gulbis, J. M., Mann, S., & MacKinnon, R. (1999) · Cell · doi:10.1016/s0092-8674(00)80805-3 · Cited by 283
Self-citation
Cited by
Sequence and structural analysis of BTB domain proteins
Stogios, P. J., Downs, G. S., Jauhal, J. J., Nandra, S. K., & Privé, G. G. (2005) · Genome Biology · doi:10.1186/gb-2005-6-10-r82 · Cited by 694
The voltage-gated potassium channels and their relatives
Yellen, G. (2002) · Nature · doi:10.1038/nature00978 · Cited by 706
Voltage-gated ion channels and gating modifier toxins
Catterall, W. A., Cestèle, S., Yarov-Yarovoy, V., Yu, F. H., Konoki, K., & Scheuer, T. (2007) · Toxicon · doi:10.1016/j.toxicon.2006.09.022 · Cited by 640
Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors
Zhou, M., Morais-Cabral, J. H., Mann, S., & MacKinnon, R. (2001) · Nature · doi:10.1038/35079500 · Cited by 560
Self-citationLocalization and Targeting of Voltage-Dependent Ion Channels in Mammalian Central Neurons
Vacher, H., Mohapatra, D. P., & Trimmer, J. S. (2008) · Physiological Reviews · doi:10.1152/physrev.00002.2008 · Cited by 488
Metadata
- Authors
- Gulbis, J. M., Zhou, M., Mann, S., & MacKinnon, R.
- Venue
- Science
- Published
- 2000-07-07
- Volume
- 289
- Issue
- 5476
- Pages
- 123-127
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1964501667
- Cited by
- 320
- References
- 3
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gulbis, J. M., Zhou, M., Mann, S., & MacKinnon, R. (2000). Structure of the Cytoplasmic β Subunit--T1 Assembly of Voltage-Dependent K + Channels. Science. https://doi.org/10.1126/science.289.5476.123
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